bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown
Published: Sept. 22, 2023
Sleep and feeding patterns lack strong daily rhythms during early life. As diurnal animals mature, is consolidated to the day sleep night. In
Language: Английский
European Journal of Neuroscience, Journal Year: 2025, Volume and Issue: 61(5)
Published: March 1, 2025
ABSTRACT Circadian rhythms influence various physiological and behavioral processes such as sleep–wake cycles, hormone secretion, metabolism. In Drosophila , an important set of circadian output neurons is called pars intercerebralis (PI) neurons, which receive input from specific clock DN1. These DN1 can further be subdivided into functionally anatomically distinctive anterior (DN1a) posterior (DN1p) clusters. The neuropeptide diuretic hormones 31 (Dh31) 44 (Dh44) are the insect neuropeptides known to activate PI control activity rhythms. However, neurophysiological basis how Dh31 Dh44 affect neural coding mechanisms underlying sleep in not well understood. Here, we identify Dh31/Dh44‐dependent spike time precision plasticity neurons. We first find that a mixture enhanced firing compared application alone alone. next synthesized affects membrane potential dynamics precise timing neuronal through their synergistic interaction, possibly mediated by calcium‐activated potassium channel conductance. Further, characterize Dh31/Dh44 enhances postsynaptic potentials Together, these results suggest multiplexed neuropeptide‐dependent .
Language: Английский
Citations
0
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 7, 2024
Abstract Circadian rhythms influence various physiological and behavioral processes such as sleep-wake cycles, hormone secretion, metabolism. output neurons are a group of that receive input from the central circadian clock located in suprachiasmatic nucleus mammalian brain transmit timing information to different regions body, coordinating processes. In Drosophila , an important set called pars intercerebralis (PI) neurons, which specific DN1. These can further be subdivided into functionally anatomically distinctive anterior (DN1a) posterior (DN1p) clusters. The neuropeptide diuretic hormones 31 (Dh31) 44 (Dh44) insect neuropeptides known activate PI control activity rhythms. However, neurophysiological basis how Dh31 Dh44 affect neural coding mechanisms underlying sleep is not well understood. Here, we identify Dh31/Dh44-dependent spike time precision plasticity neurons. We find application synthesized affects membrane potential dynamics precise neuronal firing through their synergistic interaction, possibly mediated by calcium-activated potassium channel conductance. Further, characterize Dh31/Dh44 enhances postsynaptic potentials Together, these results suggest multiplexed neuropeptide-dependent .
Language: Английский
Citations
2
Frontiers in Physiology, Journal Year: 2023, Volume and Issue: 14
Published: Jan. 19, 2023
Understanding the physiological mechanisms that modulate memory acquisition and consolidation remains among most ambitious questions in neuroscience. Massive efforts have been dedicated to deciphering how experience affects behavior, different sensory phenomena memory. Our ability encode, consolidate retrieve memories depends on internal drives, sleep stands out processes affect memory: one of relatable benefits is aiding occurs order both prepare brain learn new information, after a learning task, those memories. Drosophila lends itself study interactions between sleep. The fruit fly provides incomparable genetic resources, mapped connectome, an existing framework knowledge molecular, cellular, circuit sleep, making remarkable model decipher sophisticated regulation by quantity quality Research has stablished not only facilitates wild-type memory-impaired animals, but deprivation interferes with In addition, it well-accepted paramount processes. Finally, studies shown can promote drive. Nevertheless, molecular network underlying this intertwined relationship are still evasive. Recent work shed light neural substrates mediate sleep-dependent consolidation. similar way, mechanistic insights switch control sleep-independent strategies were recently described. This review will discuss , focusing recent advances field pointing awaiting be investigated.
Language: Английский
Citations
6
eLife, Journal Year: 2024, Volume and Issue: 13
Published: July 22, 2024
Sleep and feeding patterns lack strong daily rhythms during early life. As diurnal animals mature, is consolidated to the day sleep night. In Drosophila , circadian are initiated with formation of a circuit connecting central clock arousal output neurons; emergence also enables long-term memory (LTM). However, cues that trigger development this clock-arousal unknown. Here, we identify role for nutritional status in driving sleep-wake rhythm larvae. We find 2nd instar larval period (L2), spread across day; these behaviors become organized into by 3rd stage (L3). Forcing mature (L3) adopt immature (L2) strategies disrupts ability exhibit LTM. addition, (DN1a)-arousal (Dh44) itself influenced environment. Finally, demonstrate Dh44 neurons act through glucose metabolic genes drive onset rhythms. Together, our data suggest changes energetic demands developing organisms sleep-circadian circuits behaviors.
Language: Английский
Citations
1
Neurobiology of Sleep and Circadian Rhythms, Journal Year: 2023, Volume and Issue: 15, P. 100101 - 100101
Published: Aug. 9, 2023
Sleep disturbances are common in neurodevelopmental disorders, but knowledge of molecular factors that govern sleep young animals is lacking. Evidence across species, including
Language: Английский
Citations
2
eLife, Journal Year: 2024, Volume and Issue: 13
Published: April 29, 2024
Sleep and feeding patterns lack strong daily rhythms during early life. As diurnal animals mature, is consolidated to the day sleep night. In Drosophila , circadian are initiated with formation of a circuit connecting central clock arousal output neurons; emergence also enables long-term memory (LTM). However, cues that trigger development this clock-arousal unknown. Here, we identify role for nutritional status in driving sleep-wake rhythm larvae. We find 2nd instar larval period (L2), spread across day; these behaviors become organized into by 3rd stage (L3). Forcing mature (L3) adopt immature (L2) strategies disrupts ability exhibit LTM. addition, (DN1a)-arousal (Dh44) itself influenced environment. Finally, demonstrate Dh44 neurons act through glucose metabolic genes drive onset rhythms. Together, our data suggest changes energetic demands developing organisms sleep-circadian circuits behaviors.
Language: Английский
Citations
0
Published: June 28, 2024
Sleep and feeding patterns lack strong daily rhythms during early life. As diurnal animals mature, is consolidated to the day sleep night. In Drosophila , circadian are initiated with formation of a circuit connecting central clock arousal output neurons; emergence also enables long-term memory (LTM). However, cues that trigger development this clock-arousal unknown. Here, we identify role for nutritional status in driving sleep-wake rhythm larvae. We find 2 nd instar larval period (L2), spread across day; these behaviors become organized into by 3 rd stage (L3). Forcing mature (L3) adopt immature (L2) strategies disrupts ability exhibit LTM. addition, (DN1a)-arousal (Dh44) itself influenced environment. Finally, demonstrate Dh44 neurons act through glucose metabolic genes drive onset rhythms. Together, our data suggest changes energetic demands developing organisms sleep-circadian circuits behaviors.
Language: Английский
Citations
0
Published: June 28, 2024
Sleep and feeding patterns lack strong daily rhythms during early life. As diurnal animals mature, is consolidated to the day sleep night. In Drosophila, circadian are initiated with formation of a circuit connecting central clock arousal output neurons; emergence also enables long-term memory (LTM). However, cues that trigger development this clock-arousal unknown. Here, we identify role for nutritional status in driving sleep-wake rhythm Drosophila larvae. We find 2nd instar larval period (L2), spread across day; these behaviors become organized into by 3rd stage (L3). Forcing mature (L3) adopt immature (L2) strategies disrupts ability exhibit LTM. addition, (DN1a)-arousal (Dh44) itself influenced environment. Finally, demonstrate Dh44 neurons act through glucose metabolic genes drive onset rhythms. Together, our data suggest changes energetic demands developing organisms sleep-circadian circuits behaviors.
Language: Английский
Citations
0
Published: June 28, 2024
Sleep and feeding patterns lack strong daily rhythms during early life. As diurnal animals mature, is consolidated to the day sleep night. In Drosophila, circadian are initiated with formation of a circuit connecting central clock arousal output neurons; emergence also enables long-term memory (LTM). However, cues that trigger development this clock-arousal unknown. Here, we identify role for nutritional status in driving sleep-wake rhythm Drosophila larvae. We find 2nd instar larval period (L2), spread across day; these behaviors become organized into by 3rd stage (L3). Forcing mature (L3) adopt immature (L2) strategies disrupts ability exhibit LTM. addition, (DN1a)-arousal (Dh44) itself influenced environment. Finally, demonstrate Dh44 neurons act through glucose metabolic genes drive onset rhythms. Together, our data suggest changes energetic demands developing organisms sleep-circadian circuits behaviors.
Language: Английский
Citations
0
Published: June 28, 2024
Sleep and feeding patterns lack strong daily rhythms during early life. As diurnal animals mature, is consolidated to the day sleep night. In Drosophila, circadian are initiated with formation of a circuit connecting central clock arousal output neurons; emergence also enables long-term memory (LTM). However, cues that trigger development this clock-arousal unknown. Here, we identify role for nutritional status in driving sleep-wake rhythm Drosophila larvae. We find 2nd instar larval period (L2), spread across day; these behaviors become organized into by 3rd stage (L3). Forcing mature (L3) adopt immature (L2) strategies disrupts ability exhibit LTM. addition, (DN1a)-arousal (Dh44) itself influenced environment. Finally, demonstrate Dh44 neurons act through glucose metabolic genes drive onset rhythms. Together, our data suggest changes energetic demands developing organisms sleep-circadian circuits behaviors.
Language: Английский
Citations
0