Circadian rhythm as a therapeutic target

Nature Reviews Drug Discovery, Journal Year: 2021, Volume and Issue: 20(4), P. 287 - 307

Published: Feb. 15, 2021

Language: Английский

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Circadian rhythms and exercise — re-setting the clock in metabolic disease

Nature Reviews Endocrinology, Journal Year: 2019, Volume and Issue: 15(4), P. 197 - 206

Published: Jan. 17, 2019

Language: Английский

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Systems Chronotherapeutics

Pharmacological Reviews, Journal Year: 2017, Volume and Issue: 69(2), P. 161 - 199

Published: March 28, 2017

Chronotherapeutics aim at treating illnesses according to the endogenous biologic rhythms, which moderate xenobiotic metabolism and cellular drug response. The molecular clocks present in individual cells involve approximately fifteen clock genes interconnected regulatory feedback loops. They are coordinated by suprachiasmatic nuclei, a hypothalamic pacemaker, also adjusts circadian rhythms environmental cycles. As result, many mechanisms of diseases effects controlled timing system. Thus, tolerability nearly 500 medications varies up fivefold scheduling, both experimental models and/or patients. Moreover, treatment itself disrupted, maintained, or improved system as function timing. Improved patient outcomes on circadian-based treatments (chronotherapy) have been demonstrated randomized clinical trials, especially for cancer inflammatory diseases. However, recent technological advances highlighted large interpatient differences functions resulting significant variability chronotherapy Such findings advocate advancement personalized chronotherapeutics through interdisciplinary systems approaches. combination mathematical, statistical, technological, experimental, expertise is now shaping development dedicated devices diagnostic delivery algorithms enabling individualization. In particular, multiscale chronopharmacology approaches currently combine mathematical modeling based whole-body physiology preclinical investigations toward design patient-tailored chronotherapies. We review research works aiming individualization disease treatment, with emphasis management system–resetting strategies improving chronic control outcomes.

Language: Английский

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Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice

Science, Journal Year: 2022, Volume and Issue: 376(6598), P. 1192 - 1202

Published: May 5, 2022

Caloric restriction (CR) prolongs life span, yet the mechanisms by which it does so remain poorly understood. Under CR, mice self-impose chronic cycles of 2-hour feeding and 22-hour fasting, raising question if is calories, or time day that cause this increased span. We show here 30% CR was sufficient to extend span 10%; however, a daily fasting interval circadian alignment acted together 35% in male C57BL/6J mice. These effects were independent body weight. Aging induced widespread increases gene expression associated with inflammation decreases genes encoding components metabolic pathways liver from ad libitum-fed at night ameliorated these aging-related changes. Our results interventions promote longevity provide perspective further explore aging.

Language: Английский

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Communicating clocks shape circadian homeostasis

Science, Journal Year: 2021, Volume and Issue: 371(6530)

Published: Feb. 11, 2021

Regulating multiple body clocks Circadian rhythms that affect tissues and organ systems are aligned with the dark-light cycle other external inputs such as feeding. But how is time keeping modulated throughout complex anatomical regions? Koronowski Sassone-Corsi reviewed central regulators in brain peripheral organs can behave cooperatively or independently to modulate circadian rhythms. This systemic view of rhythm modulation important understand behavior disease, because dysregulated associated metabolic syndrome cancer. Science , this issue p. eabd0951

Language: Английский

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Time of Exercise Specifies the Impact on Muscle Metabolic Pathways and Systemic Energy Homeostasis

Cell Metabolism, Journal Year: 2019, Volume and Issue: 30(1), P. 92 - 110.e4

Published: April 18, 2019

Language: Английский

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Endocrine Crosstalk Between Skeletal Muscle and the Brain

Frontiers in Neurology, Journal Year: 2018, Volume and Issue: 9

Published: Aug. 24, 2018

Skeletal muscle is an essential regulator of energy homeostasis and a potent coordinator exercise-induced adaptations in other organs including the liver, fat or brain. muscle-initiated crosstalk with tissues accomplished though secretion myokines, protein hormones which can exert autocrine, paracrine long-distance endocrine effects. In addition, enhanced release uptake metabolites from into contracting cells, respectively, likewise act as powerful mediator tissue interactions, particular regard to central nervous system. The present review will discuss current stage knowledge regarding how exercise secretome improve broad range brain functions related vascularization, neuroplasticity, memory, sleep mood. Even molecular cellular mechanisms underlying communication between still poorly understood, physical activity represents one most effective strategies reduce prevalence incidence depression, cognitive, metabolic degenerative neuronal disorders, thus warrants further study.

Language: Английский

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Cycles in epilepsy

Nature Reviews Neurology, Journal Year: 2021, Volume and Issue: 17(5), P. 267 - 284

Published: March 15, 2021

Language: Английский

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Biomarkers of aging

Science China Life Sciences, Journal Year: 2023, Volume and Issue: 66(5), P. 893 - 1066

Published: April 11, 2023

Language: Английский

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Intermittent Fasting: Is the Wait Worth the Weight?

Current Obesity Reports, Journal Year: 2018, Volume and Issue: 7(2), P. 172 - 185

Published: April 26, 2018

Language: Английский

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