IBRO Neuroscience Reports, Journal Year: 2025, Volume and Issue: 18, P. 148 - 157
Published: Jan. 5, 2025
Language: Английский
European Heart Journal, Journal Year: 2024, Volume and Issue: 45(12), P. 987 - 997
Published: Feb. 21, 2024
Patients with severe mental illness (SMI) including schizophrenia and bipolar disorder die on average 15-20 years earlier than the general population often due to sudden death that, in most cases, is caused by cardiovascular disease. This state-of-the-art review aims address complex association between SMI risk, explore disparities care pathways, describe how adequately predict outcomes, propose targeted interventions improve health patients SMI. These have an adverse risk factor profile interplay biological factors such as chronic inflammation, patient excessive smoking, healthcare system stigma discrimination. Several pathways been demonstrated SMI, resulting a 47% lower likelihood of undergoing invasive coronary procedures substantially rates prescribed standard secondary prevention medications compared population. Although early prediction important, conventional models do not accurately long-term outcomes disease mortality are only partly driven traditional this group. As such, SMI-specific clinical tools electrocardiogram echocardiogram necessary when assessing managing associated In conclusion, there necessity for differentiated By addressing involved excess reconsidering stratification approaches, implementing multidisciplinary models, clinicians can take steps towards improving
Language: Английский
Citations
23
Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: July 18, 2024
Abstract The retina, an anatomical extension of the brain, forms physiological connections with visual cortex brain. Although retinal structures offer a unique opportunity to assess brain disorders, their relationship structure and function is not well understood. In this study, we conducted systematic cross-organ genetic architecture analysis eye-brain using imaging endophenotypes. We identified novel phenotypic links between biomarkers measures from multimodal magnetic resonance (MRI), many associations involving primary pathways. Retinal shared influences diseases complex traits in 65 genomic regions, 18 showing overlap MRI traits. Mendelian randomization suggests bidirectional causal neurological neuropsychiatric such as Alzheimer’s disease. Overall, our findings reveal basis for connections, suggesting that images can help uncover risk factors disorders disease-related changes intracranial function.
Language: Английский
Citations
18
Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 289, P. 117647 - 117647
Published: Jan. 1, 2025
Ensuring sustainable management of water is an indispensable part development, however, the limelight on long-term health risk hardness essential but remains inadequate. This study estimated effects brain system to refine its systemic assessment. We assembled a cohort 397,265 participants from UK Biobank investigate associations with neurodegenerative diseases and imaging phenotypes through modeling. found in 0-120 mg/L elevated incidence risks Alzheimer's disease vascular dementia compared that 120-300 mg/L, hazard ratios 1.13 (1.01, 1.27) 1.24 (1.05, 1.46), respectively. Furthermore, partial cerebral atrophy were also observed, including caudate nucleus inferior parietal lobule. Our provides insights into importance enacting more precise guidelines about contributes achievement Sustainable Development Goals.
Language: Английский
Citations
2
The Innovation Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 100120 - 100120
Published: Jan. 1, 2025
<p>Artificial intelligence (AI) is driving transformative changes in the field of medicine, with its successful application relying on accurate data and rigorous quality standards. By integrating clinical information, pathology, medical imaging, physiological signals, omics data, AI significantly enhances precision research into disease mechanisms patient prognoses. technologies also demonstrate exceptional potential drug development, surgical automation, brain-computer interface (BCI) research. Through simulation biological systems prediction intervention outcomes, enables researchers to rapidly translate innovations practical applications. While challenges such as computational demands, software ethical considerations persist, future remains highly promising. plays a pivotal role addressing societal issues like low birth rates aging populations. can contribute mitigating rate through enhanced ovarian reserve evaluation, menopause forecasting, optimization Assisted Reproductive Technologies (ART), sperm analysis selection, endometrial receptivity fertility remote consultations. In posed by an population, facilitate development dementia models, cognitive health monitoring strategies, early screening systems, AI-driven telemedicine platforms, intelligent smart companion robots, environments for aging-in-place. profoundly shapes medicine.</p>
Language: Английский
Citations
2
Nature Aging, Journal Year: 2024, Volume and Issue: 4(9), P. 1290 - 1307
Published: June 28, 2024
Language: Английский
Citations
13
Nature Cardiovascular Research, Journal Year: 2024, Volume and Issue: 3(6), P. 754 - 769
Published: June 17, 2024
Language: Английский
Citations
9
Neurology, Journal Year: 2025, Volume and Issue: 104(8)
Published: March 30, 2025
Cardiac dysfunction and heart failure are linked to cognitive impairment, but the underlying brain pathology remains undetermined. We investigated associations between cardiac function (measured by echocardiography or MRI), clinical failure, structural markers on MRI, including volumes of gray white matter (WM), hippocampus, hyperintensities (WMHs). leverage data from 7 prospective, community-based cohorts across Europe United States, all part Cross-Cohort Collaboration. The included were Age, Gene/Environment Susceptibility-Reykjavik Study, Atherosclerosis Risk in Communities study, Austrian Stroke Prevention Cardiovascular Health Framingham Heart Rotterdam Study Pomerania (SHIP-START SHIP-TREND). Each cohort performed cross-sectional multivariable linear regression analyses, after which estimates pooled through random-effects meta-analysis. Heterogeneity was assessed I2 index (%). Among 10,889 participants (mean age: 66.8 years, range 52.0-76.0; 56.7% women), systolic consistently associated with smaller total volume (TBV) (e.g., adjusted standardized mean difference for moderate severe -0.19, 95% CI -0.31 -0.07, = 20%). Impaired relaxation restrictive diastolic also TBV impaired -0.08, -0.15 -0.01, 32%) hippocampal (-0.18, -0.33 -0.03, 0%), similar results E/A-ratio. Systolic not WMHs. 5 available data, 302 (3.4%) had volumes, particularly hippocampus (-0.13, -0.23 -0.02, 1%). In this large study among community-dwelling adults, subclinical imaging neurodegeneration. These findings encourage longitudinal investigations effect maintaining health.
Language: Английский
Citations
1
Annual Review of Biomedical Data Science, Journal Year: 2024, Volume and Issue: 7(1), P. 225 - 250
Published: May 20, 2024
The integration of multiomics data with detailed phenotypic insights from electronic health records marks a paradigm shift in biomedical research, offering unparalleled holistic views into and disease pathways. This review delineates the current landscape multimodal omics integration, emphasizing its transformative potential generating comprehensive understanding complex biological systems. We explore robust methodologies for ranging concatenation-based to transformation-based network-based strategies, designed harness intricate nuances diverse types. Our discussion extends incorporating large-scale population biobanks dissecting high-dimensional layers at single-cell level. underscores emerging role large language models artificial intelligence, anticipating their influence as near-future pivot approaches. Highlighting both achievements hurdles, we advocate concerted effort toward sophisticated models, fortifying foundation groundbreaking discoveries precision medicine.
Language: Английский
Citations
8
National Science Review, Journal Year: 2024, Volume and Issue: 11(9)
Published: June 29, 2024
ABSTRACT Hyperpolarization stands out as a technique capable of significantly enhancing the sensitivity nuclear magnetic resonance (NMR) and imaging (MRI). Dynamic polarization (DNP), among various hyperpolarization methods, has gained prominence for its efficacy in real-time monitoring metabolism physiology. By administering hyperpolarized substrate through dissolution DNP (dDNP), biodistribution metabolic changes agent can be visualized spatiotemporally. This approach proves to distinctive invaluable tool non-invasively studying cellular vivo, particularly animal models. Biomarkers play pivotal role influencing growth metastasis tumor cells by closely interacting with them, accordingly detecting pathological alterations these biomarkers is crucial disease diagnosis therapy. In recent years, range molecular bioresponsive agents utilizing nuclei, such 13C, 15N, 31P, 89Y, etc., have been developed. this context, we explore how signals spins enhanced respond biomarkers, including pH, metal ions, enzymes, or redox processes. review aims offer insights into design principles responsive agents, target selection, mechanisms action imaging. Such discussions aim propel future development application DNP-based biomedical agents.
Language: Английский
Citations
8
Stroke, Journal Year: 2024, Volume and Issue: 55(12)
Published: Oct. 10, 2024
The burden of neurologic diseases, including stroke and dementia, is expected to grow substantially in the coming decades. Thus, achieving optimal brain health has been identified as a public priority major challenge. Cardiovascular diseases are leading cause death disability United States around world. Emerging evidence shows that heart brain, once considered unrelated organ systems, interdependent linked through shared risk factors. More recently, studies designed unravel intricate pathogenic mechanisms underpinning this association show people with various cardiac conditions may have covert microstructural changes cognitive impairment. These findings given rise idea by addressing cardiovascular earlier life, it be possible reduce deter onset or progression impairment later life. Previous scientific statements addressed between stroke. This statement discusses link 3 prevalent adults (heart failure, atrial fibrillation, coronary disease)
Language: Английский
Citations
8