eFood,
Journal Year:
2019,
Volume and Issue:
1(1), P. 24 - 37
Published: Nov. 14, 2019
Propolis
is
a
lipophilic
sticky
substance
collected
by
bees
that
has
been
used
humans
for
centuries.
Owing
to
its
healing,
antioxidant,
and
other
medicinal
properties,
chemical
composition
widely
studied.
Most
pharmacological
properties
of
propolis
have
attributed
phenols
terpenes,
mainly
flavonoids,
phenolic
acids,
their
derivatives.
More
than
500
components
were
known
from
different
parts
the
world
until
2012.
In
this
article,
305
new
constituents
described
between
2013
2018
are
being
reviewed,
with
19
additional
compounds
discovered
2011
2012,
excluded
similar
previous
review
article.
Altogether
more
850
isolated
2018.
Matéria (Rio de Janeiro),
Journal Year:
2016,
Volume and Issue:
21(3), P. 767 - 779
Published: Sept. 1, 2016
ABSTRACT
Natural
products
are
used
in
wound
healing
order
to
prevent
infection.
Propolis
is
a
well
known
antimicrobial
with
phenolic
compounds
and
flavonoid
content
which
vary
according
the
propolis
origin.
Besides
(from
both
Brazilian
UK
sources),
pomegranate,
dragon's
blood
sage
possible
antimicrobials
be
biomaterials.
The
goal
of
this
work
was
analyze
amount
phenols
these
natural
products,
their
antioxidant
activities
bonds
present
by
FTIR.
FTIR
analysis
revealed
presence
active
all
drug
samples.
quantification
showed
that
rich
compared
other
drugs,
followed
pomegranate
propolis.
most
flavonoids,
expected
on
account
its
Pomegranate,
Dragon's
presented
highest
activity.
All
samples
activity
>
82%.
Journal of Apicultural Research,
Journal Year:
2016,
Volume and Issue:
58(2), P. 1 - 49
Published: Sept. 29, 2016
Propolis
is
one
of
the
most
fascinating
honey
bee
(Apis
mellifera
L.)
products.
It
a
plant
derived
product
that
bees
produce
from
resins
they
collect
different
organs
and
with
which
mix
beeswax.
building
material
protective
agent
in
hive.
also
plays
an
important
role
social
immunity,
widely
used
by
humans
as
ingredient
nutraceuticals,
over-the-counter
preparations
cosmetics.
Its
chemical
composition
varies
geographic
location,
climatic
zone
local
flora.
The
understanding
diversity
propolis
very
research.
In
this
manuscript,
we
give
overview
available
methods
for
studying
aspects:
colony;
sources
propolis;
biological
activity
respect
to
humans;
approaches
standardization
quality
control
purposes
industrial
application.
Scientific Reports,
Journal Year:
2021,
Volume and Issue:
11(1)
Published: Jan. 21, 2021
Abstract
Gold
nanoparticles
(AuNPs)
are
highlighted
due
to
their
low
toxicity,
compatibility
with
the
human
body,
high
surface
area
volume
ratio,
and
surfaces
that
can
be
easily
modified
ligands.
Biosynthesis
of
AuNPs
using
plant
extract
is
considered
a
simple,
low-cost,
eco-friendly
approach.
Brazilian
Red
Propolis
(BRP),
product
bees,
exhibits
anti-inflammatory,
anti-tumor,
antioxidant,
antimicrobial
activities.
Here,
we
described
biosynthesis
BRP
(AuNP
)
its
fractions
hexane
,
AuNP
dichloromethane
ethyl
acetate
evaluated
structural
properties
potential
against
microorganisms
cancer
cells.
showed
plasmon
resonance
(SPR)
band
at
535
nm.
The
sizes
morphologies
were
influenced
by
sample
used
in
reaction.
FTIR
TGA
revealed
involvement
bioactive
compounds
from
or
synthesis
stabilization
AuNPs.
exhibited
activities
all
strains
tested,
showing
efficacy
as
agents
treat
infectious
diseases.
dose-dependent
cytotoxic
activity
both
T24
PC-3
highest
vitro
effect.
Also,
cytotoxicity
biogenic
was
induced
mechanisms
associated
apoptosis.
results
highlight
low-cost
green
method
red
propolis
synthesize
AuNPs,
which
demonstrated
significant
biological
properties.
PLoS ONE,
Journal Year:
2018,
Volume and Issue:
13(12), P. e0207676 - e0207676
Published: Dec. 4, 2018
Propolis
is
a
natural
product
with
many
demonstrated
biological
activities
and
propolis
extract
has
been
used
in
the
food,
pharmaceutical
cosmetics
industries.
Different
works
have
showed
variations
chemical
composition,
consequently,
on
activity
of
that
are
associated
its
type
geographic
origin.
Due
to
this
study
evaluated
extracts
obtained
through
supercritical
extraction
ethanolic
(conventional)
three
samples
different
types
(red,
green
brown),
collected
from
regions
Brazil
(state
Bahia).
Analyses
were
performed
determine
humidity,
water
activity,
content
total
ash,
proteins,
lipids
fiber
raw
samples.
The
phenolic
compounds,
flavonoids,
vitro
antioxidant
(DPPH),
catechin,
ferulic
acid
luteolin
antimicrobial
against
two
bacteria
(Staphylococcus
aureus
Escherichia
coli)
determined
for
all
extracts.
For
red
anti-leishmanicidal
potential
was
also
evaluated.
physicochemical
profiles
agreement
relation
literature.
results
identified
significant
differences
among
(p>0.05),
which
conformity
their
method,
as
well
botanical
origin
fluid
not
efficient
obtain
highest
contents
antioxidants
when
compared
best
shown
conventional
method
(ethanolic)
indicating
higher
selectivity
compounds.
variety
largest
potential,
included
found
confirm
influence
material
composition
characteristics
parameters
analysis
important
characterize
evaluate
quality
Brazilian
based
increased
use
by
products
industry.
Ultrasonics Sonochemistry,
Journal Year:
2020,
Volume and Issue:
64, P. 105021 - 105021
Published: Feb. 12, 2020
An
ultrasound
assisted
method
was
investigated
to
extract
bioactive
compounds
from
propolis.
This
based
on
a
simple
treatment
using
ethanol
as
an
extraction
medium
facilitate
the
disruption
of
propolis
cells.
Four
different
variables
were
chosen
for
determining
influence
efficiency:
ultrasonic
amplitude,
concentration,
temperature
and
time;
selected
by
Box-Behnken
design
experiments.
These
parameters
optimised
in
order
obtain
highest
yield,
results
exhibited
optimum
conditions
achieving
goal
100%
amplitude
treatment,
70%
solvent
58
°C
30
min.
The
yield
under
modified
was,
follows:
459.92
mg
GAE/g
TPC,
220.62
QE/g
TFC
1.95%
balsam
content.
showed
that
suitable
most
abundant
phenolic
compound
kaempferol
(228.8
mg/g
propolis)
followed
myricetin
(115.5
propolis),
luteolin
(27.2
quercetin
(25.2
propolis).
BMC Complementary and Alternative Medicine,
Journal Year:
2015,
Volume and Issue:
15(1)
Published: Oct. 14, 2015
The
implementation
of
new
public
healthcare
models
that
stimulate
the
use
natural
products
from
traditional
medicine,
as
a
so-called
integrated
refers
to
an
approach
best
both
conventional
medicine
and
medicine.
Propolis
is
widely
used
product
by
different
ancient
cultures
known
exhibit
biological
activities
beneficial
for
health.
large
number
studies
conducted
with
propolis
had
shown
its
chemical
composition
differs
function
climate,
plant
diversity
bee
species
plays
important
role
on
therapeutic
properties.
aim
this
study
was
analyse
phytochemical
profile
ethanolic
extract
red
(EEP)
fractionation,
antioxidant
action
EEP
fractions
hexane,
cloroform
ethyl
acetate
cytotoxic
activity
human
tumour
cell
lines
SF-295
(glioblastoma),
OVCAR-8
(ovary)
HCT-116
(colon).EEP
obtained
maceration
absolute
ethanol,
then
it
concentrated
in
rotaevaporator
up
complete
evaporation
solvent.
crude
fractionated
acetate,
chloroform
methanol
they
were
subjected
screening
total
phenolic
compounds.
Antioxidant
done
means
2,2-diphenyl-1-picryhydrazyl
(DPPH)
method.
Biomarkers
identified
LC-Orbitrap-FTMS.
To
assess
extract,
cells
exposed
over
72
h.
Cell
viability
assessed
MTT
assay.
percentage
growth
inhibition
(IC50)
analysed
non-linear
regression,
absorbance
values
various
investigated
concentrations
one-factor
analysis
variance
(ANOVA)
followed
Tukey's
or
Tamhane's
tests
(α
=
0.05).The
results
using
LC-Orbitrap-FTMS
indicated
presence
phlobaphene
tannins,
catechins,
chalcones,
aurones,
flavonones,
flavonols,
xanthones,
pentacyclic
triterpenoids
guttiferones
Brazilian
propolis.
liquid-liquid
partitioning
exhibited
satisfactory
percentages.
(IC50
<
34.27
μg/mL)
high
levels
cytotoxicity
all
tested
when
compared
negative
control.C-Orbitrap-FTMS
useful
establish
has
properties
decreases
substantially
survival
cells;
thus,
potential
serve
anticancer
drug.
Evidence-based Complementary and Alternative Medicine,
Journal Year:
2017,
Volume and Issue:
2017(1)
Published: Jan. 1, 2017
Although
there
is
evidence
of
the
benefits
propolis
on
human
health,
vast
majority
studies
have
been
conducted
using
animal
models.
The
present
study
includes
chemical
characterization
and
clinical
evaluation
effects
oral
administration
solution
oxidative
status
modulation
lipids
in
a
population
Talca,
Chile.
Chemical
propolis,
total
phenol,
flavonoids,
antioxidant
capacity
were
determined
by
ORAC.
Identification
phenols
flavonoids
was
assessed
HPLC-DAD.
A
double-blind,
placebo-controlled
trial
conducted.
Subjects
provided
informed
consent
form
Bioethics
Committee
Universidad
de
Talca
approved
protocol.
Eligible
subjects
(n
=
67)
randomized
two
groups:
35)
placebo
32).
All
evaluated
at
0
(baseline),
45,
90
days.
In
group,
we
observed
that
increases
HDL-c
went
from
53.9
±
11.9
to
65.8
16.7
mg/dL
(p
<
0.001)
baseline
Compared
subjects,
consumption
induced
net
increase
GSH
levels
0.0001)
decrease
TBARS
for
group.
Our
findings
indicate
potential
use
health.
appears
positive
improvement
HDL-c,
both
which
contribute
reduced
risk
cardiovascular
disease.
