Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease

Kidney International, Journal Year: 2013, Volume and Issue: 83(6), P. 1029 - 1041

Published: Jan. 16, 2013

Language: Английский

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Effect of Uremia on Structure and Function of Immune System

Journal of Renal Nutrition, Journal Year: 2011, Volume and Issue: 22(1), P. 149 - 156

Published: Dec. 24, 2011

Language: Английский

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Chronic Kidney Disease as Oxidative Stress- and Inflammatory-Mediated Cardiovascular Disease

Antioxidants, Journal Year: 2020, Volume and Issue: 9(8), P. 752 - 752

Published: Aug. 14, 2020

Generating reactive oxygen species (ROS) is necessary for both physiology and pathology. An imbalance between endogenous oxidants antioxidants causes oxidative stress, contributing to vascular dysfunction. The ROS-induced activation of transcription factors proinflammatory genes increases inflammation. This phenomenon crucial importance in patients with chronic kidney disease (CKD), because atherosclerosis one the critical their cardiovascular (CVD) increased mortality. effect ROS disrupts excretory function each section nephron. It prevents maintenance intra-systemic homeostasis leads accumulation metabolic products. Renal regulatory mechanisms, such as tubular glomerular feedback, myogenic reflex supplying arteriole, renin-angiotensin-aldosterone system, are also affected. makes it impossible compensate water-electrolyte acid-base disturbances, which progress further mechanism positive leading a intensification stress. As result, progression CKD observed, spectrum complications malnutrition, calcium phosphate abnormalities, atherosclerosis, anemia. review aimed show role stress inflammation renal impairment, particular emphasis on its influence most common disturbances that accompany CKD.

Language: Английский

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Dyslipidemia in patients with chronic kidney disease

Reviews in Endocrine and Metabolic Disorders, Journal Year: 2016, Volume and Issue: 18(1), P. 29 - 40

Published: Dec. 20, 2016

Language: Английский

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Lipid (per) oxidation in mitochondria: an emerging target in the ageing process?

Biogerontology, Journal Year: 2017, Volume and Issue: 18(6), P. 859 - 879

Published: May 24, 2017

Lipids are essential for physiological processes such as maintaining membrane integrity, providing a source of energy and acting signalling molecules to control including cell proliferation, metabolism, inflammation apoptosis. Disruption lipid homeostasis can promote pathological changes that contribute towards biological ageing age-related diseases. Several diseases have been associated with altered metabolism an elevation in highly damaging peroxidation products; the latter has ascribed, at least part, mitochondrial dysfunction elevated ROS formation. In addition, senescent cells, which known significantly pathologies, also impaired function metabolism. Therapeutic targeting dysfunctional is emerging strategy alleviating their negative impact during progression Such therapies could include use drugs prevent uncoupling, inhibit inflammatory synthesis, modulate transport or storage, reduce oxidative stress eliminate cells from tissues. this review, we provide overview structure function, emphasis on lipids potential therapeutic disease.

Language: Английский

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Relation of Serum Lipids and Lipoproteins with Progression of CKD

Clinical Journal of the American Society of Nephrology, Journal Year: 2014, Volume and Issue: 9(7), P. 1190 - 1198

Published: May 16, 2014

Background and objectives Hyperlipidemia is common in patients with CKD. The objective of this study was to evaluate whether measures plasma lipids lipoproteins predict progression kidney disease Design, setting, participants, & measurements Prospective cohort adults (n=3939) CKD aged 21–74 years recruited between 2003 2008 followed for a median 4.1 years. At baseline, total cholesterol, triglycerides, very-low-density lipoprotein cholesterol (VLDL-C), LDL (LDL-C), HDL (HDL-C), apoA-I , apoB, lipoprotein(a) [Lp(a)] were measured. outcomes composite end point ESRD or 50% decline eGFR from baseline (rate change GFR). Results Mean age the population 58.2 years, mean GFR 44.9 ml/min per 1.73 m2; 48% had diabetes. None lipid independently associated risk rate GFR. However, there significant (P=0.01) interactions by level proteinuria. In participants proteinuria<0.2 g/d, 1-SD higher LDL-C 26% lower renal (hazard ratio [HR], 0.74; 95% confidence interval [95% CI], 0.59 0.92; P=0.01), 23% (HR, 0.77; CI, 0.62 0.96; P=0.02). proteinuria>0.2 neither 0.98; 0.98 1.05) nor levels outcomes. Treatment statins reported 55% differential across categories. Conclusions large CKD, VLDL-C, LDL-C, HDL-C, apoA-I, Lp(a) not disease. There an inverse relationship low

Language: Английский

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Randomized, Controlled Trial of Glucose-Sparing Peritoneal Dialysis in Diabetic Patients

Journal of the American Society of Nephrology, Journal Year: 2013, Volume and Issue: 24(11), P. 1889 - 1900

Published: Aug. 16, 2013

Glucose-containing peritoneal dialysis solutions may exacerbate metabolic abnormalities and increase cardiovascular risk in diabetic patients. Here, we examined whether a low-glucose regimen improves control patients undergoing dialysis. Eligible were randomly assigned 1:1 manner to the group (dextrose only) or intervention (IMPENDIA trial: combination of dextrose-based solution, icodextrin amino acids; EDEN different acids) followed for 6 months. Combining both studies, 251 allocated (n=127) (n=124) across 11 countries. The primary endpoint was change glycated hemoglobin from baseline. Mean at baseline similar groups. In intention-to-treat population, mean profile improved but remained unchanged (0.5% difference between groups; 95% confidence interval, 0.1% 0.8%; P=0.006). Serum triglyceride, very-low-density lipoprotein, apolipoprotein B levels also group. Deaths serious adverse events, including several related extracellular fluid volume expansion, increased group, however. These data suggest that indices receiving be associated with an expansion. Thus, use glucose-sparing regimens should accompanied by close monitoring status.

Language: Английский

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Dyslipidemia, Kidney Disease, and Cardiovascular Disease in Diabetic Patients

The Review of Diabetic Studies, Journal Year: 2013, Volume and Issue: 10(2-3), P. 88 - 100

Published: Jan. 1, 2013

The Review of Diabetic Studies,2013,10,2-3,88-100.DOI:10.1900/RDS.2013.10.88Published:August 2013Type:Review Article Authors:Szu-chi Chen, and Chin-Hsiao Tseng Author(s) affiliations:Szu-chi Chen1 Tseng1,2,3 1Division Endocrinology Metabolism, Department Internal Medicine, National Taiwan University Hospital, Taipei, TAIWAN. 2Department College 3Division Environmental Health Occupational Medicine the Research Institutes, Abstract:This article reviews relationship between dyslipidemia, chronic kidney disease, cardiovascular diseases in patients with diabetes. Diabetes mellitus is associated complications renal system, increasing prevalence worldwide. Modification multifactorial risk factors, particular has been suggested to reduce rates diabetes-related complications. Dyslipidemia diabetes a condition that includes hypertriglyceridemia, low high-density lipoprotein levels, increased small dense low-density particles. This higher mortality diabetic patients. Current treatment guidelines focus on lowering cholesterol level; multiple trials have confirmed benefits statins. Chronic disease also contributes dyslipidemia turn related occurrence progression nephropathy. Different patterns are different stages Some shown statins not only decreased events, but delayed However, studies using as sole hyperlipidemia dialysis respect risk. nephropathy events than those without degree albuminuria reduction estimated glomerular filtration rate correlated events. Treatment angiotensinconverting enzyme inhibitors angiotensin II receptor blockers decrease morbidity mortality. Keywords:Cardiovascular Dyslipidemia, Type 2 diabetesView:PDF (171.36 KB)

Language: Английский

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Serum Metabolite Concentrations and Decreased GFR in the General Population

American Journal of Kidney Diseases, Journal Year: 2012, Volume and Issue: 60(2), P. 197 - 206

Published: March 30, 2012

Language: Английский

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Association of Dyslipidemia with Renal Outcomes in Chronic Kidney Disease

PLoS ONE, Journal Year: 2013, Volume and Issue: 8(2), P. e55643 - e55643

Published: Feb. 4, 2013

Dyslipidemia is highly prevalent in patients with chronic kidney disease (CKD) and the relationship between dyslipidemia renal outcomes moderate to advanced CKD remains controversial. Hence, our objective determine whether independently associated rapid progression replacement therapy (RRT) patients. The study analyzed association lipid profile, RRT, (estimated glomerular filtration rate [eGFR] slope <-6 ml/min/1.73 m(2)/yr) 3303 stages 3 5 CKD. During a median 2.8-year follow-up, 1080 (32.3%) participants commenced RRT 841 (25.5%) had progression. In adjusted models, lowest quintile (hazard ratios [HR], 1.23; 95% confidence interval [CI], 1.01 1.49) highest two quintiles of total cholesterol (HR, 1.25; CI, 1.02 1.52 HR, 1.35; 1.11 1.65 respectively) increased risks for (vs. 2). Besides, was (odds ratio, 1.36; 1.83). Our demonstrated that certain levels were stage 3-5. Assessment profile may help identify high risk groups adverse outcomes.

Language: Английский

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