Galectin-3 as a biomarker for periodontal disease severity in postcoronavirus disease 2019 patients: A clinical and biochemical investigation DOI Creative Commons

Nimisha Mithradas,

Uma Sudhakar, Vijayalakshmi Rajaram

et al.

Journal of Indian Society of Periodontology, Journal Year: 2024, Volume and Issue: 28(5), P. 551 - 556

Published: Sept. 1, 2024

Abstract: Background: The relationship between coronavirus disease 2019 (COVID-19) and periodontitis has been interesting. Understanding this connection is crucial for comprehensive patient care highlights the importance of monitoring addressing oral health issues in an individual’s post-COVID-19 recovery. This study compared evaluated serum Galectin-3 (Gal-3) levels clinical parameters healthy individuals with chronic no history COVID-19 patients periodontitis. Materials Methods: Group I consists 25 Stage II Grade B periodontitis, without any (Group II), controls III) were recruited study. Gal-3 assessed using enzyme-linked immunosorbent assay (ELISA) kit. Clinical periodontal variables measured recorded, including attachment level (CAL), plaque index (PI), probing pocket depth (PPD). Data analyses done one-way analysis variance (ANOVA) test Tukey’s honest significant difference post hoc tests. Results: had a higher concentrations 14.757 ng/ml to 11.127 8.673 III, respectively, mean was statistically P = 0.000. PPD, CAL, PI significantly high Groups III Conclusion: current study’s findings demonstrated that increased participants. relevance treating during post-COVID-19/long-COVID era need maintain hygiene by identifying possible biomarkers understanding specific underlying processes.

Language: Английский

TMPRSS2 expression in oral mucosal cells induced by transfected double-stranded RNA and IL-1β DOI
Misaki Akagi, Kouji Ohta, Miyuki Sakuma

et al.

Journal of Oral Biosciences, Journal Year: 2025, Volume and Issue: unknown, P. 100619 - 100619

Published: Feb. 1, 2025

Language: Английский

Citations

0
Salivary periostin levels as a non-invasive biomarker and their clinical correlates among healthy and periodontitis patients—a cross-sectional analytical study DOI Creative Commons

Priyanka S. Padalkar,

Sunaina Shetty Yadadi,

Gopinath Vivekanandan

et al.

Frontiers in Dental Medicine, Journal Year: 2025, Volume and Issue: 6

Published: March 19, 2025

Background The diagnosis of periodontitis is primarily through clinical and radiographic assessments. However, it difficult for clinicians to detect incipient during the routine assessment. Identifying people at risk tracking disease development need a dependable biomarker. Currently, no biomarkers meet all criteria required an ideal diagnostic test. Therefore, utility salivary periostin as potential screening tool warrants further investigation, particularly large samples across diverse populations. present study aimed investigate levels biomarker in individuals with healthy controls. Methods Forty-five patients generalized stage III grade A/B equivalent number periodontally controls were evaluated plaque index (PI), gingival (GI), pocket probing depth (PPD), attachment level (CAL). Unstimulated from subjects taken, quantified using ELISA kit. Results average 4.63 group 1.24 ( P < 0.05). Spearman coefficient indicated negative correlation between r = −0.761), −0.780; 0.05), (PPD) −0.713; 0.05) (CAL) Linear regression analysis validated indirect indicators (Adjusted R square 0.947). Conclusions Salivary are associated periodontal disease. indirectly influence non-invasive periodontitis. effective evaluating both diseased periodontium.

Language: Английский

Citations

0
Unraveling the Link between Periodontitis and Coronavirus Disease 2019: Exploring Pathogenic Pathways and Clinical Implications DOI Creative Commons

En-Chin Lin,

Yi-Chun Chiang, Hsuan‐Yu Lin

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(10), P. 2789 - 2789

Published: Oct. 14, 2023

Periodontitis involves the inflammation of periodontal tissue, leading to tissue loss, while coronavirus disease 2019 (COVID-19) is a highly transmissible respiratory caused by severe acute syndrome 2 (SARS-CoV-2), which amplified poor systemic health. Key facilitators SARS-CoV-2's entry into host cells are angiotensin-converting enzyme (ACE2) and transmembrane serine protease (TMPRSS2). This review reveals that pockets can serve as hotspot for virus accumulation, rendering surrounding epithelia more susceptible infection. Given ACE2 expressed in oral mucosa, it reasonable suggest health could increase risk COVID-19 However, recent studies have not provided sufficient evidence imply significant effect on health, necessitating further long-term investigations. Nevertheless, there hypotheses linking mechanisms two diseases, such involvement interleukin-17 (IL-17). Elevated IL-17 levels observed both periodontitis, increased osteoclast activity bone resorption. Lastly, bidirectional relationships between periodontitis diseases like diabetes acknowledged. symptoms may worsen with these conditions, maintaining good managing suggested potential ways protect against COVID-19.

Language: Английский

Citations

7
Patients’ knowledge about dental emergencies, COVID-19 transmission, and required preparations in dental settings DOI Creative Commons
Mohammad Reza Khami, Mahsa Karimi, Morẹ́nikẹ́ Oluwátóyìn Foláyan

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(4), P. e0301460 - e0301460

Published: April 18, 2024

The Coronavirus disease 2019 (COVID-19) pandemics negatively affected the delivery of dental care. study objective was to assess knowledge emergency treatments, transmission routes COVID-19 in settings, necessary precautions prevent transmission, and associations between demographic factors mentioned domains among Iranian patients.

Language: Английский

Citations

1
Comorbidity of respiratory diseases and periodontal diseases DOI Creative Commons
Д. И. Трухан,

Anatoly F. Sulimov,

L. Yu. Trukhan

et al.

Meditsinskiy sovet = Medical Council, Journal Year: 2024, Volume and Issue: 13, P. 270 - 278

Published: Sept. 1, 2024

At the beginning of 21st century, concept “periodontal medicine” was formed, within framework which bidirectional connection periodontal pathology with systemic diseases body is considered. There are two hypotheses regarding possibility chronic infection to contribute development inflammation: 1) changes in microbiocenosis oral cavity and inflammation lead an increase bacterial translocation into bloodstream, causing circulation inflammatory mediators immune complexes other organs systems body; 2) can disturbances intestinal microbiome due intake periodontopathic organisms. The relationship between respiratory has been less studied. We searched Pubmed Scopus databases for articles published up January 31, 2024, that addressed this relationship. proximity continuity tract allows be a major determinant pulmonary microbiome. It possible distinguish 2 main ways bacteria lungs - aerogenic aspiration. data presented review suggest probable hospital-acquired pneumonia, new coronavirus COVID-19, COPD. BA considered possible, but number studies not confirmed, requires further study. community-acquired pneumonia practically studied, it taking account direct interaction microbiota along mouth-lung axis, indirectly mouth-intestinal-lung axis. Non-surgical treatment likely effective prevention diseases. indicate importance health need periodontitis patients.

Language: Английский

Citations

0
Oral Health Related Factors Predicting Severe COVID‐19 Disease in Elderly Swedes DOI Creative Commons
Ann‐Katrin Johansson, Ridwaan Omar, Sverre Lehmann

et al.

Journal of Oral Rehabilitation, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 16, 2024

ABSTRACT Objectives To analyse different background factors that may serve as predictors for acquiring symptoms of severe COVID‐19 disease. Methods A postal questionnaire was sent to the total population individuals born between 1942 (80 years, n = 6299) and 1932 (90 1904) living in Örebro Östergötland counties, Sweden, 2017 repeated 2022. Tentative predictive self‐reported disease were based on responses from related general oral health prior outbreak pandemic. Results Response rate main 2022 66% (5375/8203), 577 reported having been sick with out which 359 agreed answer a separate COVID‐19. This returned by 278/359 participants corresponding response 77%. Information gleaned pre‐COVID‐19 survey revealed relatively large number associations severity subsequently several diverse tentative found unadjusted regression analyses. Based statistically significant correlations adjusted analysis, (based self‐reports 2017) contracting decreasing order odds ratios (OR): removable partial or complete denture usage (OR 6.2, CI 2.2–17.2); periodontal problems past year 3.4, 1.1–10.4); daytime dry mouth 2.5, 1.2–5.2). Conclusion Removable dentures, developing

Language: Английский

Citations

0
Galectin-3 as a biomarker for periodontal disease severity in postcoronavirus disease 2019 patients: A clinical and biochemical investigation DOI Creative Commons

Nimisha Mithradas,

Uma Sudhakar, Vijayalakshmi Rajaram

et al.

Journal of Indian Society of Periodontology, Journal Year: 2024, Volume and Issue: 28(5), P. 551 - 556

Published: Sept. 1, 2024

Abstract: Background: The relationship between coronavirus disease 2019 (COVID-19) and periodontitis has been interesting. Understanding this connection is crucial for comprehensive patient care highlights the importance of monitoring addressing oral health issues in an individual’s post-COVID-19 recovery. This study compared evaluated serum Galectin-3 (Gal-3) levels clinical parameters healthy individuals with chronic no history COVID-19 patients periodontitis. Materials Methods: Group I consists 25 Stage II Grade B periodontitis, without any (Group II), controls III) were recruited study. Gal-3 assessed using enzyme-linked immunosorbent assay (ELISA) kit. Clinical periodontal variables measured recorded, including attachment level (CAL), plaque index (PI), probing pocket depth (PPD). Data analyses done one-way analysis variance (ANOVA) test Tukey’s honest significant difference post hoc tests. Results: had a higher concentrations 14.757 ng/ml to 11.127 8.673 III, respectively, mean was statistically P = 0.000. PPD, CAL, PI significantly high Groups III Conclusion: current study’s findings demonstrated that increased participants. relevance treating during post-COVID-19/long-COVID era need maintain hygiene by identifying possible biomarkers understanding specific underlying processes.

Language: Английский

Citations

0