Nutrition Reviews,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 15, 2025
Abstract
Context
Although
low-carbohydrate
(LC)
diets
have
been
shown
to
be
beneficial
for
weight
loss
and
improvements
in
cardiometabolic
health
adults
with
obesity,
their
efficacy
youth
has
not
yet
established.
Objectives
A
systematic
review
meta-analysis
was
conducted
qualitatively
quantitively
synthesize
the
evidence
from
clinical
trials
testing
of
LC
improve
anthropometric
cardiometabolic-related
parameters
children
adolescents
obesity.
Data
Sources
Searches
Medline,
EMBASE,
Cochrane
databases
were
undertaken
interventions
or
without
control
comparisons.
Extraction
Analysis
before
after
intervention
comparisons
(if
applicable)
extracted
19
studies,
17
which
pooled
random-effects
meta-analyses.
Results
Children
on
(Mean
=
30
[IQR:
30-60]
g/d),
approximately
3
months
(IQR:
3-4
months)
significantly
reduced
(mean
change
[MC]
-7.09
[95%
CI:
-9.60,
-4.58]
kg;
P
<
.001),
body
mass
index
(BMI)
(MC
-3.01
[-3.71,
-2.30]
kg/m2;
BMI
z-score
-0.27
[-0.48,
-0.06];
.020),
average,
concomitant
different
metabolic
biomarkers,
such
as
serum
triglycerides
-29.16
[-45.06,
-13.26]
mg/dL;
.002)
insulin
-7.13
[-9.27,
-4.99]
µU/mL;
.001).
Evidence
5
out
7
controlled
suggests
that
caloric
restriction
may
lead
similar
greater
lipid-related
outcomes
relative
caloric-restricted
low-fat
diets.
However,
meta-analyses
demonstrated
high
between-study
heterogeneity,
indicative
a
wide
variety
methodologies,
including
duration
degree
carbohydrate
restriction.
Conclusion
Overall,
this
found
short-term
can
improving
calorie
limited
number
demonstrable
diversity
methods
prevent
firm
conclusions
regarding
traditional
approaches,
energy
Systematic
Review
Registration
PROSPERO
registration
no.
CRD42023440835.
Journal of Internal Medicine,
Journal Year:
2023,
Volume and Issue:
295(4), P. 508 - 531
Published: Oct. 23, 2023
Abstract
In
recent
decades,
global
life
expectancies
have
risen
significantly,
accompanied
by
a
marked
increase
in
chronic
diseases
and
population
aging.
This
narrative
review
aims
to
summarize
findings
on
the
dietary
factors
influencing
longevity,
primarily
from
large
cohort
studies.
First,
maintaining
healthy
weight
throughout
is
pivotal
for
aging
mirroring
benefits
of
lifelong,
moderate
calorie
restriction
today's
obesogenic
food
environment.
Second,
specific
types
or
sources
fat,
protein,
carbohydrates
are
more
important
disease
risk
mortality
than
their
quantity.
Third,
some
traditional
diets
(e.g.,
Mediterranean,
Nordic,
Okinawa)
contemporary
patterns,
such
as
plant‐based
diet
index,
DASH
(dietary
approaches
stop
hypertension)
diet,
alternate
eating
been
associated
with
lower
longevity.
These
patterns
share
many
common
components
predominance
nutrient‐rich
plant
foods;
limited
red
processed
meats;
culinary
herbs
spices
prevalent
cuisines)
while
embracing
distinct
elements
different
cultures.
Fourth,
combining
other
lifestyle
could
extend
disease‐free
8–10
years.
While
adhering
core
principles
diets,
it
crucial
adapt
recommendations
individual
preferences
cultures
well
nutritional
needs
populations.
Public
health
strategies
should
aim
create
healthier
environment
where
nutritious
options
readily
accessible,
especially
public
institutions
care
facilities
elderly.
Although
further
mechanistic
studies
human
trials
needed
better
understand
molecular
effects
aging,
there
pressing
need
establish
maintain
long‐term
cohorts
studying
culturally
diverse
EClinicalMedicine,
Journal Year:
2024,
Volume and Issue:
70, P. 102519 - 102519
Published: March 11, 2024
Benefits
of
Intermittent
fasting
(IF)
on
health-related
outcomes
have
been
found
in
a
range
randomised
controlled
trials
(RCTs).
Our
umbrella
review
aimed
to
systematically
analyze
and
synthesize
the
available
causal
evidence
IF
its
impact
specific
while
evaluating
quality.
Nutrients,
Journal Year:
2025,
Volume and Issue:
17(2), P. 310 - 310
Published: Jan. 16, 2025
Polycystic
ovary
syndrome
(PCOS)
is
one
of
the
most
prevalent
endocrine
disorders
among
reproductive-aged
women.
It
characterized
by
hyperandrogenism,
anovulation,
and
polycystic
ovaries.
Lifestyle
changes
are
suggested
as
first-line
interventions
in
managing
PCOS.
This
systematic
review
aims
to
assess
scientific
evidence
regarding
role
lifestyle
modifications
(dietary
changes,
physical
activity,
behavioral
changes)
improving
reproductive,
anthropometric,
metabolic,
psychological
outcomes
women
with
Dietary
such
foods
low
glycemic
index
scores;
caloric
restrictions;
high-fiber,
omega
three
fatty
acid-rich
diets;
ketogenic
Mediterranean
antioxidant-rich
food;
anti-inflammatory
diets
improve
insulin
sensitivity
hormonal
balance
Physical
like
aerobic
resistance
exercise,
enhances
sensitivity,
helps
weight
loss,
improves
metabolic
reproductive
Further,
education
modules
can
also
be
used
awareness,
adherence,
effectiveness
conventional
treatment
manage
mental
health
issues
related
Collectively,
not
only
biochemical,
hormonal,
anthropometric
parameters
PCOS
patients
but
reduce
long-term
risks
cardiovascular
diseases.
BJPsych Open,
Journal Year:
2025,
Volume and Issue:
11(2)
Published: Feb. 25, 2025
Background
Preliminary
evidence
suggests
that
a
ketogenic
diet
may
be
effective
for
bipolar
disorder.
Aims
To
assess
the
impact
of
in
disorder
on
clinical,
metabolic
and
magnetic
resonance
spectroscopy
outcomes.
Method
Euthymic
individuals
with
(
N
=
27)
were
recruited
to
6-
8-week
single-arm
open
pilot
study
modified
diet.
Clinical,
MRS
measures
assessed
before
after
intervention.
Results
Of
27
participants,
26
began
20
completed
For
participants
completing
intervention,
mean
body
weight
fell
by
4.2
kg
P
<
0.001),
mass
index
1.5
kg/m
2
0.001)
systolic
blood
pressure
7.4
mmHg
0.041).
The
euthymic
had
average
baseline
follow-up
assessments
consistent
them
being
range
no
statistically
significant
changes
Affective
Lability
Scale-18,
Beck
Depression
Inventory
Young
Mania
Rating
Scale.
In
providing
reliable
daily
ecological
momentary
assessment
data
n
14),
there
was
positive
correlation
between
ketone
levels
self-rated
mood
r
0.21,
energy
0.19
an
inverse
both
impulsivity
−0.30,
anxiety
−0.19,
0.001).
From
measurements,
brain
glutamate
plus
glutamine
concentration
decreased
11.6%
anterior
cingulate
cortex
0.025)
13.6%
posterior
<0.001).
Conclusions
These
findings
suggest
clinically
useful
disorder,
mental
health
Replication
randomised
controlled
trials
are
now
warranted.
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(14), P. 3120 - 3120
Published: July 12, 2023
The
ketogenic
diet
(KD)
is,
nowadays,
considered
an
interesting
nutritional
approach
for
weight
loss
and
improvement
in
insulin
resistance.
Nevertheless,
most
of
the
studies
available
literature
do
not
allow
a
clear
distinction
between
its
effects
on
sensitivity
per
se,
induced
by
KDs
sensitivity.
In
this
review,
we
discuss
scientific
evidence
direct
mediated
glycemic
status
humans,
describing
KD's
biochemical
background
underlying
mechanisms.
Nutrition Reviews,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 14, 2024
Abstract
Context
Despite
the
important
role
of
inflammation-related
factors
on
occurrence
chronic
diseases,
there
is
still
conflicting
evidence
about
effects
ketogenic
diet
(KD)
these
factors.
Objective
In
order
to
obtain
a
better
viewpoint,
this
study
aimed
comprehensively
investigate
KD
markers.
Data
Sources
To
find
pertinent
randomized
controlled
trials
up
August
2023,
databases
including
PubMed/Medline,
Web
Science,
Scopus,
Cochrane
Library,
and
Embase
were
searched.
Extraction
This
included
all
investigating
C-reactive
protein
(CRP),
tumor
necrosis
factor-alpha
(TNF-α),
interleukin
(IL)-6,
IL-8,
IL-10
levels.
Pooled
weighted
mean
difference
(WMD)
95%
confidence
intervals
(CIs)
achieved
by
random-effects
model
analysis
for
best
estimation
outcomes.
Analysis
Forty-four
studies
in
article.
The
pooled
findings
showed
that
has
an
effect
lowering
TNF-α
(WMD:
−0.32
pg/mL;
CI:
−0.55,
−0.09;
P
=
0.007)
IL-6
−0.27
−0.52,
−0.02;
0.036)
compared
with
control
groups.
However,
no
significant
was
reported
others
inflammation
marker–related
results
subgroup
that,
following
≤8
weeks
people
aged
≤50
years,
reduction
levels
significantly
higher
than
other
addition,
body
mass
index
greater
30
kg/m2
≤30
kg/m2,
decreased
extent
after
receiving
KD.
Conclusions
Consequently,
adherence
appears
improve
some
markers
associated
inflammation,
IL-6.
Medicine & Science in Sports & Exercise,
Journal Year:
2024,
Volume and Issue:
56(10), P. 2076 - 2091
Published: Sept. 15, 2024
ABSTRACT
Excessive
body
weight
and
adiposity
contribute
to
many
adverse
health
concerns.
The
American
College
of
Sports
Medicine
(ACSM)
recognizes
that
the
condition
excess
is
complex,
with
numerous
factors
warranting
consideration.
ACSM
published
a
position
stand
on
this
topic
in
2001
an
update
2009,
consensus
paper
role
physical
activity
prevention
gain
2019.
This
current
serves
as
additional
those
prior
papers.
supports
inclusion
medical
treatments
(pharmacotherapy,
metabolic
bariatric
surgery)
adiposity,
deemed
be
medically
appropriate,
provides
perspectives
within
these
therapies.
For
loss
gain,
effects
may
most
prevalent
when
progressed
appropriate
manner
at
least
150
min·wk
−1
moderate-intensity
activity,
benefits
occur
dose–response
manner.
High-intensity
interval
training
does
not
appear
superior
moderate-to-vigorous
for
regulation,
light-intensity
also
alternative
approach
provided
it
sufficient
energy
expenditure.
Evidence
support
any
one
single
mode
other
modes
or
loss,
elicit
holistic
beyond
multimodal
should
recommended.
interaction
between
expenditure
intake
exercise
control
appetite
are
variable
individuals.
Physical
interventions
inclusive
tailored
sex,
self-identified
gender,
race,
ethnicity,
socioeconomic
status,
age,
developmental
level.
Intervention
approaches
can
include
different
forms,
channels,
methods
activity.