Materials Today Communications, Journal Year: 2025, Volume and Issue: unknown, P. 112978 - 112978
Published: May 1, 2025
Language: Английский
Korean Circulation Journal, Journal Year: 2025, Volume and Issue: 55
Published: Jan. 1, 2025
Exosomes, small extracellular vesicles ranging from 30 to 150 nanometers in diameter, have emerged as pivotal mediators of intercellular communication. These vesicles, originally perceived cellular debris, are now recognized for their intricate roles transporting bioactive molecules, including proteins, lipids, and nucleic acids, between cells. Exosomes received considerable attention due diverse physiological pathological processes, especially relation cardiovascular diseases (CVDs). CVDs intricately linked, sharing common risk factors mechanisms, such inflammation, oxidative stress, endothelial dysfunction. been implicated either directly or indirectly influencing these phenomena. They secreted by virtually all cell types, cells, cardiomyocytes, stem play critical maintaining vascular homeostasis responding stimuli. Their capacity traverse biological barriers, maintain stability circulation, effectively encapsulate deliver a variety molecular cargos makes them promising candidates both biomarkers therapeutic agents. This review aims explore the multifaceted exosomes CVDs. And we will discuss mechanisms exosome biogenesis release, composition, ways which they contribute disease pathophysiology. Additionally, emphasize potential diagnostic uses, highlighting significance advancement innovative treatment strategies. explores recent findings advancements research, emphasizing CVD paving way future studies clinical applications.
Language: Английский
Citations
1
Journal of Molecular Histology, Journal Year: 2025, Volume and Issue: 56(2)
Published: April 1, 2025
Language: Английский
Citations
1
Stem Cell Research & Therapy, Journal Year: 2025, Volume and Issue: 16(1)
Published: April 23, 2025
Intrauterine adhesion (IUA) refers to endometrial fibrosis resulting from injury and infection. In promoting the repair of endometrium, mesenchymal stem cells therapy has shown great potential. However, adult-derived (MSCs) are associated with several challenges, including invasive manipulation, susceptibility contamination, low proliferative capacity. Immunity-and-matrix-regulatory (IMRCs) derived human embryonic exhibit enhanced immunomodulatory anti-fibrotic capabilities. Despite their success in treating lung fibrosis, membranous nephropathy, acute liver failure, therapeutic potential IUA remains undetermined. TGF-β1-induced stromal (HESCs) were utilized construct cell model treated IMRCs conditioned medium. Morphological changes observed, RT-qPCR Western blot analyses employed detect expression relevant markers during process epithelial-mesenchymal transition (EMT) vitro. The rat was established using dual method subsequently intrauterine infusion IMRCs. HE Masson staining used assess damage, extent fibrosis. Fertility assays performed compare effectiveness umbilical cord (UCMSCs) improving function rats. Sequencing analysis IMRCs-derived exosomes (Exos) conducted identify specific miRNAs pathways they target. TGF-β1 treatment induced HESCs undergo fibrotic transformation express fibrosis-related markers, while medium inhibited rats facilitated damaged restored structure uterine cavity, reduced collagen deposition. reversed EMT IUA, upregulated epithelial downregulated markers. further exerted antifibrotic effects by reducing inflammatory responses. recovery receiving superior that UCMSCs. Specific Exos, miR-27b-3p, miR-145-5p, miR-16-5p, directly target Smad2, inhibit Smad2 phosphorylation, modulate TGF-β/Smad pathway. Our study demonstrated HESCs, suppressed ex vivo, response, damage through paracrine pathway, Exos downregulating signaling pathway provide a new direction for IUA.
Language: Английский
Citations
0
Materials Today Communications, Journal Year: 2025, Volume and Issue: unknown, P. 112929 - 112929
Published: May 1, 2025
Language: Английский
Citations
0
Materials Today Communications, Journal Year: 2025, Volume and Issue: unknown, P. 112978 - 112978
Published: May 1, 2025
Language: Английский
Citations
0