Hybrid Machine Learning Classification for Tipple Negative Breast Cancer DOI

Hend A. Bakr,

Amira M. Abozaid,

Ahmed B. Zaky

et al.

Published: Dec. 18, 2023

This research introduces an innovative approach to dissecting Triple-Negative Breast Cancer (TNBC) by integrating count-based RNA analysis and machine learning techniques. Through the strategic amalgamation of K-means clustering, Convolutional Neural Network (CNN), Support Vector Machine (SVM), this study transcends conventional classification methods, revealing detailed molecular insights within complex TNBC landscape. The methodology initiates with for dimensionality reduction, refining classifications through clustering. incorporation CNN allows nuanced feature extraction, capturing intricate genomic relationships, while SVM enhances subtype predictions precise classification. addition Gene Ontology (GO) pathway analyses enriches our understanding unraveling functional implications identified gene clusters. synergistic not only advances comprehension subtypes but also establishes a groundwork targeted therapeutic strategies. fusion enables comprehensive exploration complexity, offering valuable personalized oncology approaches in era precision medicine

Language: Английский

Global trends and forecasts of breast cancer incidence and deaths DOI Creative Commons
Yuyan Xu,

Maoyuan Gong,

Yue Wang

et al.

Scientific Data, Journal Year: 2023, Volume and Issue: 10(1)

Published: May 27, 2023

Breast cancer (BC) is one of the major public health challenges worldwide. Studies that address new evidence on trends BC are great importance for preventing and controlling occurrence development diseases improving health. The aim this study was to analyze outcomes global burden disease (GBD), incidence, deaths, risk factors from 1990 2019, predict GBD until 2050 inform control planning efforts. In study, results show regions with low levels socio-demographic index (SDI) will have largest in future. leading factor death attributable 2019 metabolic risks, followed by behavioral risks. This supports worldwide urgent need comprehensive prevention strategies reduce exposure, early screening, improve treatment effectively BC.

Language: Английский

Citations

165
Recent advances in Metal-Organic Frameworks as nanocarriers for triggered release of anticancer drugs: Brief history, biomedical applications, challenges and future perspective DOI

Syeda Fiza Fatima,

Rana Sabouni,

Renuka Garg

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2023, Volume and Issue: 225, P. 113266 - 113266

Published: March 15, 2023

Language: Английский

Citations

41
Analyzing Cancer Incidence Trends in Oman From 1996 to 2019: A Comprehensive Study of the National Cancer Annual Reports DOI Creative Commons
Hasan Al‐Sayegh,

Shoaib Al‐Zadjali,

Mansour Al‐Moundhri

et al.

JCO Global Oncology, Journal Year: 2024, Volume and Issue: 10

Published: Jan. 25, 2024

PURPOSE Previous studies have reported that cancer incidence trends in Oman varied by tumor site and sex. No comprehensive analysis of all sites had been reported. The objective this study is to analyze calculate the annual percent change (APC) age-standardized rates (ASRs) for all-cancer 61 individual Omani men women from 1996 2019. METHODS We gathered data National Cancer Registry cancers combined sites. estimated APC using Poisson regression. RESULTS ASR population increased 23% (from 95/100,000 117.2/100,000 2019), with increase being more pronounced females (48% v 7% males). Among male population, there was significant ASRs colon, rectum, thyroid, prostate cancers, APCs 6.92%, 4.24%, 4.19%, 2.03%, respectively. females, showed (APC = 1.39%), increasing were observed uterine, breast (APCs 7.57%, 7.08%, 5.19%, 5.16%, respectively). CONCLUSION significantly but not men. Uterine highest APC. Colorectal thyroid both males females. Breast trends. Further research needed explore factors contributing incidences.

Language: Английский

Citations

7
Epidemiology of Breast, Corpus Uteri, and Ovarian Cancers in Lebanon With Emphasis on Breast Cancer Incidence Trends and Risk Factors Compared to Regional and Global Rates DOI Creative Commons
Najla A. Lakkis, Reem Abdallah, Umayya Musharrafıeh

et al.

Cancer Control, Journal Year: 2024, Volume and Issue: 31

Published: Jan. 1, 2024

This study explores the incidence and trends of breast (Bca), corpus uteri (CUca), ovarian (Oca) cancer in Lebanon, a Middle Eastern country. It compares Bca rates to regional global ones discusses risk factors Lebanon.

Language: Английский

Citations

7
Temporal Trends of Asthma Among Children in the Western Pacific Region From 1990 to 2045: Longitudinal Observational Study DOI Creative Commons
Cheng-hao Yang, Xin-yu Li, Jia-jie Lv

et al.

JMIR Public Health and Surveillance, Journal Year: 2024, Volume and Issue: 10, P. e55327 - e55327

Published: March 14, 2024

Asthma has become one of the most common chronic conditions worldwide, especially among children. Recent findings show that prevalence childhood asthma increased by 12.6% over past 30 years, with >262 million people currently affected globally. The reasons for growing epidemic remain complex and multifactorial.

Language: Английский

Citations

6
Current and future burden of female breast cancer in the Middle East and North Africa region using estimates from GLOBOCAN 2022 DOI Open Access
Mariam Zahwe,

Karima Bendahhou,

Sultan Eser

et al.

International Journal of Cancer, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Breast cancer is the most diagnosed female and common cause of death in women Middle East North Africa (MENA) region. In this study, we aimed to describe current patterns breast among MENA region estimate burden for year 2050. We used estimates incidence mortality from GLOBOCAN 2022 database predicted 2050 according different scenarios. With 118,200 new cases 41,000 deaths, contributed 25% almost 20% MENA. The highest rates were Algeria Iraq (≥60/100,000) lowest Saudi Arabia Yemen (<30/100,000). Iraq, Syrian Arab Republic, Algeria, Sudan (>20/100,000), (7.6/100,000). While low compared other world regions, (16.9/100,000) higher than any except Sub‐Saharan Africa. <50 years 5.5 times lower aged ≥50 years, Western countries. By 2050, estimated increase 219,000 88,900 deaths (86% 117%, respectively). Scaling up control curb rising alongside improved surveillance vital develop targeted interventions improving outcomes.

Language: Английский

Citations

0
Epidemiology of the most Prevalent Cancers in Ninewa between 2017–2021 DOI Creative Commons
Firas Khathayer,

Mohammad Hussein Mikael,

S. Z. Kadhim

et al.

Epidemiology and Vaccinal Prevention, Journal Year: 2025, Volume and Issue: 23(6), P. 34 - 46

Published: Jan. 12, 2025

Purpose . Cancer is characterized by abnormal cell growth resulting from uncontrolled division. These cells spread and form metastatic lesions in normal tissues, leading to loss of tissue organ function. one the most life-threatening diseases worldwide that develops humans. regardless sex, ethnicity, or nationality.Material methods. Here, we conducted a retrospective study collect data on various types cancers prevalent Ninewa, Iraq, between 2017–2021, using hospital records pooled Iraq Registry. We focused top 10 notable Results Our revealed number novel cancer cases mortality rates have been increasing annually 2017– 2021. Females had higher occurrence than males. The Ninewa were breast women lung men. Leukemia was common pediatric cancer. Furthermore, this reported highest rate followed Conclusion provides statistical overview governorate, will be useful clinicians, faculty members other professionals medical field.

Language: Английский

Citations

0
Exploring barriers to early breast examination and screening among Arab women in the MENA region: A KAP study DOI Creative Commons

Ehsan Qtaishat,

Reem Al-Ajlouni, Khawlah Ammar

et al.

Heliyon, Journal Year: 2025, Volume and Issue: 11(3), P. e42167 - e42167

Published: Jan. 23, 2025

To examine the knowledge, attitudes, and practices (KAP) regarding early breast cancer screening among women across MENA region. This cross-sectional investigation deployed a survey designed to investigate women's KAP with regards signs symptoms, detection methods, sources of barriers towards exams. The was distributed over social media platforms during period between June 2022-September 2022. Responses were reported as frequencies analyzed per participants demographic characteristics. A total 2681 Arab included in final analysis. Sudan (31.3 %), Saudi Arabia (15.6 Palestine (14.0 %) most represented countries. Only 53.4 % able recognize at least 5 symptoms cancer. While family history risk factor for (85.6 onset menarche (23.0 late menopause (24.0 recognized. Participants well aware self-breast examination (SBE) 72.0 practicing it on regular basis. Conversely, while nearly half sample clinical examinations (CBE) or mammography (MM), less than 50 knowledgeable abouts their proper suitable age. In terms barriers, lack current issues knowledge commonly all three forms methods. Univariate analysis demonstrated that regularly SBE CBE associated higher (all p < 0.05). Also, older more likely be compliant SBE, CBE, MM 0.001). Area residence did not impact Among our population sampled adult women, cancer, its factors, methods are satisfactory. Thus, we recommend increased awareness efforts profound exploration effectiveness such interventions.

Language: Английский

Citations

0
Critical Diagnostic Delay Thresholds in Breast Cancer: A Molecular Subtype-Based Causal Analysis From Saudi Arabia DOI Open Access

Reem A Alsalamah

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Introduction Diagnostic delays in breast cancer can significantly affect treatment outcomes. Currently, the causal mechanisms and critical time thresholds remain poorly defined across different molecular subtypes of cancer. We investigated relationship between diagnostic outcomes based on data from our center, with a focus identifying actionable intervention points within pathway. Methods conducted retrospective cohort study 802 patients treated at King Fahad Specialist Hospital Qassim Province, Saudi Arabia (2017-2024). Using directed acyclic graphs mediation analysis, we quantified pathways through which impact Markov chain modeling was utilized to determine subtype-specific where stage migration probability exceeds 10%. Results found that 589 (73.5%) experienced high-risk (over two months). Stage emerged as primary mediator, accounting for 67.3% (95% CI: 58.4-76.1%) total effect survival. have identified multiple subtypes: 38 days triple-negative, 52 HER2-positive, 85 ER+/PR+/HER2- tumors. Hazard ratios mortality increased progressively delay duration, 1.18 1.05-1.32) weeks one month 2.35 2.06-2.67) are equal or more than year, translating an average 3.40 life years lost per patient. Conclusions The is fundamentally governed by tumor biology, significant vulnerability aligned aggressiveness. Our findings support applying biologically informed triage system characteristics maximum acceptable intervals. suggested approach, may achieve better balance resource constraints biological imperatives, possibly improve survival without proportional increases healthcare expenditure.

Language: Английский

Citations

0
Global burden of asthma in young adults in 204 countries and territories, 1990–2019: Systematic analysis of the Global burden of disease study 2019 DOI Creative Commons
Cheng-hao Yang,

Jia-jie Lv,

Xin-yu Li

et al.

Preventive Medicine Reports, Journal Year: 2023, Volume and Issue: 37, P. 102531 - 102531

Published: Dec. 6, 2023

Asthma is a common chronic respiratory disease, with onset usually occurring during childhood or adolescence. The aim of this study was to estimate the dynamic changes in burden asthma disease among adolescents (aged 15-39 years). Between 1990 and 2019, our comprehensive analysis spanned 204 nations territories ascertain global prevalence asthma. This extensive evaluation meticulously quantified disease's by examining range critical metrics-including mortality rates, figures, disability-adjusted life-years (DALYs)-across diverse demographics. Our investigation systematically segmented data age, gender, year, as well geographical regions Socio-demographic Index (SDI), offering an in-depth perspective on multifaceted impact worldwide. From there increase incidence cases young adults, number rising from 6487957.18 (95 %UI: 4578735.08-8736387.55) 7604488.39 % UI:5428024.98-10177808.25). rate adults exhibited decline 580.09 per 1,00,000 %UI:481.37-757.28) 504.28 %UI:400.64-633.26). It also noteworthy that rates remaining SDI regions, although lower, showed varying degrees 2015. age-standardized for has over course previous three decades. Nevertheless, characterized lower demonstrate elevated asthma, thereby warranting focused attention prioritized allocation medical resources.

Language: Английский

Citations

10