Prevalence, Incidence, and Metabolic Characteristics of Young Adults with Type 2 Diabetes Mellitus in South Korea (2010–2020)

Diabetes & Metabolism Journal, Journal Year: 2025, Volume and Issue: 49(2), P. 172 - 182

Published: March 1, 2025

Background: This study aimed to examine trends in the prevalence, incidence, metabolic characteristics, and management of type 2 diabetes mellitus (T2DM) among young adults South Korea.Methods: Young with T2DM were defined as individuals aged 19 39 years who met diagnostic criteria for T2DM. Data from Korean National Health Insurance Service-Customized Database (2010–2020, <i>n</i>=225,497–372,726) analyzed evaluate profiles, comorbidities, antidiabetic drug prescription. Additional analyses performed using Korea Nutrition Examination Survey.Results: The prevalence significantly increased 1.02% 2010 2.02% 2020 (<i>P</i><0.001), corresponding 372,726 patients 2020. Over same period, incidence rate remained stable within range 0.36% 0.45%. Prediabetes steadily 15.53% 20.92%, affecting 3.87 million proportion obese also increased, 67.8% having a body mass index (BMI) ≥25 kg/m² 31.6% BMI ≥30 hypertension, dyslipidemia, fatty liver disease reaching 34.2%, 79.8%, 78.9%, respectively, Although overall pharmacological treatment low, prescription medications weight-reducing properties over period.Conclusion: nearly doubled past decade. strong association obesity comorbidities emphasizes urgent need targeted prevention strategies tailored this population.

Language: Английский

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A Phase III Randomized, Double-Blind, Active-Controlled, Multicenter Study on the Efficacy and Safety of Ezetimibe/Atorvastatin/Amlodipine Combination in Patients With Comorbid Primary Hypercholesterolemia and Essential Hypertension

Clinical Therapeutics, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

This study aimed to evaluate the efficacy and safety of triple combination ezetimibe (Eze)/atorvastatin (Ato) 10/40 mg + amlodipine (Aml) 10 therapy for lowering low-density lipoprotein cholesterol (LDL-C) blood pressure compared with either Eze/Ato or Aml therapies in patients comorbid primary hypercholesterolemia essential hypertension. was a randomized, multicenter, double-blind, active-controlled, Phase III clinical trial. Participants underwent wash-out period (2 weeks nonfibrate medications, 6 fibrates) followed by 4 therapeutic lifestyle changes. Subsequently, 109 participants were randomly assigned 3 groups: (1) mg, (2) (3) mg. The coprimary end points percentage change LDL-C mean sitting systolic (SBP) baseline at week 8. A total enrolled study, there no statistically significant differences characteristics across groups. After 8 treatment, least-square (LS) (SE) percent from -57.95% (3.52%) group 8.93% (3.54%) group. LS difference between these 2 groups -66.88 (4.95) (95% CI, -76.77% -56.99%) (P < 0.0001). Furthermore, 8, SBP -19.24 (2.42) mm Hg -4.43 (2.56) Hg, respectively. -14.81 (3.53) -21.87 -7.74) No serious adverse drug reactions occurred any Triple has effectively reduced independently, over treatment period. In terms safety, among research lays groundwork development fixed-dose future, which could improve patient convenience adherence reducing pill burden. Clinical Research Information Service (CRIS), Republic Korea: KCT0006283.

Language: Английский

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Adherence to Antidiabetic Medication and Cardiovascular Outcomes in Cancer Patients: A Nationwide Population-Based Cohort Study

Cancers, Journal Year: 2025, Volume and Issue: 17(7), P. 1117 - 1117

Published: March 26, 2025

Cancer survivors increasingly face cardiovascular disease (CVD), with diabetes as a major risk factor. This study investigates the relationship between adherence to antidiabetic medications and (CV) outcomes in cancer patients. Using data from Korean National Health Insurance Service-National Sample Cohort, we assessed clinical of adult patients prescribed medications. The population was categorized based on medication adherence, determined by possession ratio (MPR): good (MPR ≥ 0.8), moderate (0.5 ≤ MPR < poor 0.5) adherence. primary included overall CV mortality, secondary encompassing hospitalization for CVDs healthcare costs. Among 7928 diabetes, 59.7% were nonadherent (22.1% 37.6% adherence). Over median follow-up 5.7 years, 1462 deaths 2897 events confirmed. Multivariable adjusted analyses showed 1.70-fold 2.11-fold higher mortality groups, respectively, compared group. For associated 1.51-fold risk, 2.10-fold risk. new-onset increased 1.32-fold group 1.44-fold also significantly lower total costs nonadherence present underscores importance patients, revealing significant associations decreased events,

Language: Английский

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Mendelian Randomization Study on hs-CRP and Dyslipidemia in Koreans: Identification of Novel SNP rs76400217

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 506 - 506

Published: Jan. 9, 2025

High-sensitivity C-reactive protein (hs-CRP) is a marker of systemic inflammation and associated with developing dyslipidemia. However, the causality between hs-CRP dyslipidemia remains unresolved. This study aimed to investigate relationship concentrations explore potential causal link using Mendelian randomization (MR) analysis. A nested case–control was conducted 1174 participants, genotype data were analyzed Korean Chip. genome-wide association (GWAS) identified rs76400217 as suitable instrumental variable (IV) due its significant (p < 10−8). Logistic regression models, adjusted for confounders, used evaluate An MR analysis performed two-stage least squares (2SLS) method, IV assess causality. showed (OR 2.08, 95% CI: 1.81–2.39, p 0.001). remained after adjusting factors such age, sex, alcohol consumption, BMI. The confirmed strong associations 0.001) in all but not statistically significant. Thus, no evidence risk found population. observed may be other contributing rather than direct cause.

Language: Английский

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Journal of Lipid and Atherosclerosis in 2025: From Excellence to Eminence

Journal of Lipid and Atherosclerosis, Journal Year: 2025, Volume and Issue: 14(1), P. 1 - 1

Published: Jan. 1, 2025

Language: Английский

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Application of Generative Artificial Intelligence in Dyslipidemia Care

Journal of Lipid and Atherosclerosis, Journal Year: 2025, Volume and Issue: 14(1), P. 77 - 77

Published: Jan. 1, 2025

Dyslipidemia dramatically increases the risk of cardiovascular diseases, necessitating appropriate treatment techniques. Generative AI (GenAI), an advanced technology that can generate diverse content by learning from vast datasets, provides promising new opportunities to address this challenge. GenAI-powered frequently asked questions systems and chatbots offer continuous, personalized support addressing lifestyle modifications medication adherence, which is crucial for patients with dyslipidemia. These tools also help promote health literacy making information more accessible reliable. GenAI helps healthcare providers construct clinical case scenarios, training materials, evaluation tools, supports professional development evidence-based practice. Multimodal analyzes food images nutritional deliver dietary recommendations tailored each patient's condition, improving long-term management those Moreover, using image generation enhances visual quality educational materials both professionals, allowing create real-time, customized aids. To apply successfully, must develop GenAI-related abilities, such as prompt engineering critical GenAI-generated data.

Language: Английский

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Navigating the Gray Zone: Is Intensive Lipid-Lowering Always Necessary in Patients With Atherosclerotic Cardiovascular Disease?

Korean Circulation Journal, Journal Year: 2025, Volume and Issue: 55(5), P. 437 - 437

Published: Jan. 1, 2025

Language: Английский

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The association between the triglyceride–glucose index and vulnerable plaques in patients with type 2 diabetes mellitus: insights from coronary computed tomography angiography

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: April 16, 2025

The triglyceride‒glucose index (TyG index) has been verified to be a useful predictor of insulin resistance (IR), and is associated with the occurrence acute coronary syndrome (ACS). However, effect TyG on vulnerable plaques (VP), which were identified when at least two high-risk features are present within same lesion, in type 2 diabetes mellitus (T2DM) patients not fully understood. This study aimed explore association between presence VP. We retrospectively enrolled 2056 T2DM who underwent computed tomography angiography (CCTA) examinations West China Hospital from February 2017 2022. These divided into four groups basis quartiles index. plaque features, plaques, type, artery stenosis, segment involvement score (SIS), stenosis (SSS) multivessel disease (MVD) based CCTA data evaluated compared among groups. Patients higher had more noncalcified mixed fewer calcified (P < 0.05 for all). proportion including low-attenuation positive remodeling "napkin ring" sign was trend Multivariate analysis revealed that significantly [OR = 1.23 (95% CI 1.00-1.51), P 0.046]. Subgroup varied age prevalence cardiovascular (CVD) symptoms, even after controlling confounding factors interaction both). independently T2DM. could regarded as marker reduce incidence events targeted population patients.

Language: Английский

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Screening for Prediabetes and Diabetes in Korean Nonpregnant Adults: A Position Statement of the Korean Diabetes Association, 2022

Diabetes & Metabolism Journal, Journal Year: 2022, Volume and Issue: 46(6), P. 819 - 826

Published: Nov. 24, 2022

Diabetes screening serves to identify individuals at high-risk for diabetes who have not yet developed symptoms and diagnose an early stage. Globally, the prevalence of is rapidly increasing. Furthermore, obesity and/or abdominal obesity, which are major risk factors type 2 mellitus (T2DM), progressively increasing, particularly among young adults. Many patients with T2DM asymptomatic can accompany various complications time diagnosis, as well chronic develop duration increases. Thus, proper diagnosis essential care. Based on reports changing epidemiology in Korea, growing evidence from new national cohort studies screening, Korean Association has updated its clinical practice recommendations regarding screening. now recommended adults aged ≥35 years regardless presence factors, all (aged ≥19) any factors. Abdominal based waist circumference (men ≥90 cm, women ≥85 cm) was added list

Language: Английский

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Association of low muscle strength with metabolic dysfunction-associated fatty liver disease: A nationwide study

World Journal of Gastroenterology, Journal Year: 2023, Volume and Issue: 29(45), P. 5962 - 5973

Published: Dec. 1, 2023

There is limited evidence regarding the association between muscle strength and metabolic dysfunction-associated fatty liver disease (MAFLD).To investigate MAFLD in general population Korea.This nationwide representative cross-sectional study included 31649 individuals aged ≥ 19 years who participated Korea National Health Nutrition Examination Survey 2015 2018. Odds ratios (ORs) 95% confidence intervals (95%CIs) for according to sex-specific quartiles of strength, defined by relative handgrip were calculated using multivariable logistic regression analysis. Additionally, analysis was used assess probable fibrosis patients with MAFLD.Of all participants, 29.3% had MAFLD. The prevalence significantly higher lower quartile groups sexes, age (P < 0.001). A 1.92-fold (OR = 1.92, 95%CI: 1.70-2.16) 3.12-fold 3.12, 2.64-3.69) risk observed lowest (Q1) group than other (Q2-Q4) highest (Q4) group, respectively. ORs increased a dose-dependent manner trend These associations persisted both sexes. An inverse subgroups age, obesity, diabetes mellitus. In MAFLD, odds severe Q1 1.83, 1.25-2.69) (Q2-Q4).Among Korean adults, low associated an

Language: Английский

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