The electrogenicity of the Na+/K+-ATPase poses challenges for computation in highly active spiking cells DOI Open Access
Liz Weerdmeester, Jan‐Hendrik Schleimer, Susanne Schreiber

et al.

Published: Jan. 27, 2025

The evolution of the Na + /K -ATPase laid foundation for ion homeostasis and electrical signalling. While not required restoration ionic gradients, electrogenicity pump (resulting from its 3:2 stoichiometry) is useful to prevent runaway activity. As we show here, also comes with disadvantageous side effects: (1) an activity-dependent shift in a cell’s baseline firing (2) interference computation, disturbing network entrainment when inputs change strongly. We exemplify these generic effects mathematical model weakly electric fish electrocyte, which spikes at hundreds Hz exposed abrupt rate changes producing behaviourally-relevant communication signals. discuss biophysical strategies allowing cells mitigate consequences additional metabolic cost postulate interesting role voltage-dependence -ATPase. Our work shows that pump’s opens axis vulnerability likely play brain disease.

Language: Английский

The electrogenicity of the Na+/K+-ATPase poses challenges for computation in highly active spiking cells DOI Open Access
Liz Weerdmeester, Jan‐Hendrik Schleimer, Susanne Schreiber

et al.

Published: Jan. 27, 2025

The evolution of the Na + /K -ATPase laid foundation for ion homeostasis and electrical signalling. While not required restoration ionic gradients, electrogenicity pump (resulting from its 3:2 stoichiometry) is useful to prevent runaway activity. As we show here, also comes with disadvantageous side effects: (1) an activity-dependent shift in a cell’s baseline firing (2) interference computation, disturbing network entrainment when inputs change strongly. We exemplify these generic effects mathematical model weakly electric fish electrocyte, which spikes at hundreds Hz exposed abrupt rate changes producing behaviourally-relevant communication signals. discuss biophysical strategies allowing cells mitigate consequences additional metabolic cost postulate interesting role voltage-dependence -ATPase. Our work shows that pump’s opens axis vulnerability likely play brain disease.

Language: Английский

Citations

0
The electrogenicity of the Na+/K+-ATPase poses challenges for computation in highly active spiking cells DOI Open Access
Liz Weerdmeester, Jan‐Hendrik Schleimer, Susanne Schreiber

et al.

Published: Jan. 27, 2025

The evolution of the Na + /K -ATPase laid foundation for ion homeostasis and electrical signalling. While not required restoration ionic gradients, electrogenicity pump (resulting from its 3:2 stoichiometry) is useful to prevent runaway activity. As we show here, also comes with disadvantageous side effects: (1) an activity-dependent shift in a cell’s baseline firing (2) interference computation, disturbing network entrainment when inputs change strongly. We exemplify these generic effects mathematical model weakly electric fish electrocyte, which spikes at hundreds Hz exposed abrupt rate changes producing behaviourally-relevant communication signals. discuss biophysical strategies allowing cells mitigate consequences additional metabolic cost postulate interesting role voltage-dependence -ATPase. Our work shows that pump’s opens axis vulnerability likely play brain disease.

Language: Английский

Citations

0