Threat imminence reveals links among unfolding of anticipatory physiological response, cortical-subcortical intrinsic functional connectivity, and anxiety DOI Creative Commons
Rany Abend,

Sonia G. Ruiz,

Mira Bajaj

et al.

Neurobiology of Stress, Journal Year: 2022, Volume and Issue: 16, P. 100428 - 100428

Published: Jan. 1, 2022

Excessive expression of fear responses in anticipation threat occurs anxiety, but understanding underlying pathophysiological mechanisms is limited. Animal research indicates that threat-anticipatory defensive are dynamically organized by imminence and rely on conserved circuitry. Insight from basic neuroscience animals could guide mechanistic humans mapping abnormal function this circuitry to aberrant pathological anxiety. 50 pediatric anxiety patients healthy-comparisons (33 females) completed an instructed threat-anticipation task whereby cues signaled delivery painful (threat) or non-painful (safety) thermal stimulation. Temporal changes skin-conductance indexed effects anticipatory responding as imminence. Multivariate network analyses resting-state functional connectivity data a subsample were used identify intrinsic-function correlates anticipatory-response dynamics, within specific, distributed derived translational responding. By considering imminence, revealed specific effects. Importantly, was associated with excessive deployment physiological response threat, not safety, outcomes became more imminent. Magnitude increase corresponded magnitude intrinsic cortical-subcortical circuit. Moreover, severe stronger associations between ventromedial prefrontal cortex showed hippocampus basolateral amygdala, regions implicated animal models These findings link clinical research, highlighting variations potential mechanism

Language: Английский

The prefrontal cortex, pathological anxiety, and anxiety disorders DOI Open Access
Margaux M. Kenwood, Ned H. Kalin, Helen Barbas

et al.

Neuropsychopharmacology, Journal Year: 2021, Volume and Issue: 47(1), P. 260 - 275

Published: Aug. 16, 2021

Language: Английский

Citations

187
The nature and neurobiology of fear and anxiety: State of the science and opportunities for accelerating discovery DOI Creative Commons
Shannon E. Grogans, Eliza Bliss‐Moreau, Kristin A. Buss

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2023, Volume and Issue: 151, P. 105237 - 105237

Published: May 18, 2023

Language: Английский

Citations

46
Viral tunes: changes in musical behaviours and interest in coronamusic predict socio-emotional coping during COVID-19 lockdown DOI Creative Commons
Lauren K. Fink, Lindsay Warrenburg, Claire Howlin

et al.

Humanities and Social Sciences Communications, Journal Year: 2021, Volume and Issue: 8(1)

Published: July 26, 2021

Abstract Beyond immediate health risks, the COVID-19 pandemic poses a variety of stressors, which may require expensive or unavailable strategies during (e.g., therapy, socialising). Here, we asked whether musical engagement is an effective strategy for socio-emotional coping. During first lockdown period (April–May 2020), surveyed changes in music listening and making behaviours over 5000 people, with representative samples from three continents. More than half respondents reported engaging to cope. People experiencing increased negative emotions used solitary emotional regulation, whereas people positive as proxy social interaction. Light gradient-boosted regressor models were identify most important predictors individual’s use cope, foremost was, intriguingly, their interest “coronamusic.” Overall, our results emphasise importance real-time responses societal crises, well individually tailored adaptations meet needs.

Language: Английский

Citations

74
Understanding anxiety symptoms as aberrant defensive responding along the threat imminence continuum DOI Creative Commons
Rany Abend

Neuroscience & Biobehavioral Reviews, Journal Year: 2023, Volume and Issue: 152, P. 105305 - 105305

Published: July 5, 2023

Language: Английский

Citations

42
Pathological fear, anxiety and negative affect exhibit distinct neurostructural signatures: evidence from psychiatric neuroimaging meta-analysis DOI Creative Commons
Xiqin Liu, Benjamin Klugah‐Brown, Ran Zhang

et al.

Translational Psychiatry, Journal Year: 2022, Volume and Issue: 12(1)

Published: Sept. 23, 2022

Internalizing disorders encompass anxiety, fear and depressive disorders, which exhibit overlap at both conceptual symptom levels. Given that a neurobiological evaluation is lacking, we conducted Seed-based D-Mapping comparative meta-analysis including coordinates as well original statistical maps to determine common disorder-specific gray matter volume alterations in generalized anxiety disorder (GAD), fear-related (FAD, i.e., social disorder, specific phobias, panic disorder) major (MDD). Results showed GAD exhibited altered volumes relative FAD decreased left insula lateral/medial prefrontal cortex increased right putamen volume. Both MDD compared controls FAD. While less robust lingual gyrus controls, this group presented intact frontal integrity. No shared structural abnormalities were found. Our study the first provide meta-analytic evidence for distinct neuroanatomical underlying pathophysiology of anxiety-, disorders. These findings may have implications determining promising target regions neuromodulation interventions (e.g. transcranial magnetic stimulation or neurofeedback).

Language: Английский

Citations

40
A neural signature for the subjective experience of threat anticipation under uncertainty DOI Creative Commons
Xiqin Liu,

Guojuan Jiao,

Feng Zhou

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Feb. 20, 2024

Abstract Uncertainty about potential future threats and the associated anxious anticipation represents a key feature of anxiety. However, neural systems that underlie subjective experience threat under uncertainty remain unclear. Combining an uncertainty-variation paradigm allows precise modulation level momentary arousal during functional magnetic resonance imaging (fMRI) with multivariate predictive modeling, we train brain model accurately predicts intensity test it across 9 samples (total n = 572, both gender). Using publicly available datasets, demonstrate whole-brain signature specifically is not sensitive in predicting pain, general or unspecific emotional autonomic arousal. The also functionally spatially distinguishable from representations fear negative affect. We develop sensitive, generalizable, specific neuroimaging marker for uncertain can facilitate development.

Language: Английский

Citations

15
Are Fear and Anxiety Truly Distinct? DOI Creative Commons
Lucie Daniel‐Watanabe, Paul C. Fletcher

Biological Psychiatry Global Open Science, Journal Year: 2021, Volume and Issue: 2(4), P. 341 - 349

Published: Oct. 13, 2021

Fear and anxiety are largely seen as separate entities, a distinction that inspires shapes basic clinical research. Evidence for this has rich translational base comes from physiological, behavioral, neurobiological studies. However, there is high degree of inconsistency number fundamental limitations lead us to question the validity distinction. We consider range studies examining specifically whether how may manifest at neural, behavioral levels, we highlight inconsistencies call into question. go on critically examine assumptions in approaches fear-anxiety implications these have weighing evidence against Acknowledging contention over emotion research animals easily translatable subjective experience humans, conclude although between fear proved useful informative, reasons recognizing it an oversimplification future progress be guided, but should not limited, by it.

Language: Английский

Citations

54
Robust BOLD Responses to Faces But Not to Conditioned Threat: Challenging the Amygdala's Reputation in Human Fear and Extinction Learning DOI Creative Commons
Renée M. Visser, Joe Bathelt, H. Steven Scholte

et al.

Journal of Neuroscience, Journal Year: 2021, Volume and Issue: 41(50), P. 10278 - 10292

Published: Nov. 8, 2021

Most of our knowledge about human emotional memory comes from animal research. Based on this work, the amygdala is often labeled brain's “fear center”, but it unclear to what degree neural circuitries underlying fear and extinction learning are conserved across species. Neuroimaging studies in humans yield conflicting findings, with many failing show activation response learned threat. Such null findings treated as resulting MRI-specific problems related measuring deep brain structures. Here we test assumption a mega-analysis three acquisition ( n = 98; 68 female) 79; 53 female). The conditioning procedure involved presentation two pictures faces houses: one each pair was followed by an electric shock [a conditioned stimulus (CS + )], other never – ), participants were instructed learn these contingencies. Results revealed widespread responses CS compared network, including anterior insula, midcingulate cortex, thalamus, bed nucleus stria terminalis, not amygdala, which actually responded stronger . independent spatial smoothing, individual differences trait anxiety pupil responses. In contrast, robust distinguished houses, refuting idea that poor signal could account for absence effects. Moving forward, suggest that, apart imaging larger samples at higher resolution, alternative statistical approaches may be used identify cross-species similarities learning. SIGNIFICANCE STATEMENT science provides foundation numerous theories psychopathology, stress disorders. This field relies heavily research, suggests central role memory. However, finding strongly corroborated neuroimaging evidence humans, too easily explained away methodological limitations inherent large nonclinical sample, find BOLD fear, amygdala. A While do disprove involvement learning, they challenge its typical portrayals illustrate complexities translational science.

Language: Английский

Citations

46
Controllability over stressor decreases responses in key threat-related brain areas DOI Creative Commons

Chirag Limbachia,

Kelly Morrow,

Anastasiia Khibovska

et al.

Communications Biology, Journal Year: 2021, Volume and Issue: 4(1)

Published: Jan. 5, 2021

Abstract Controllability over stressors has major impacts on brain and behavior. In humans, however, the effect of controllability responses to is poorly understood. Using functional magnetic resonance imaging (fMRI), we investigated how altered a shock-plus-sound stressor with between-group yoked design, where participants in controllable uncontrollable groups experienced matched exposure. Employing Bayesian multilevel analysis at level regions interest voxels insula, standard voxelwise analysis, found that decreased stressor-related across threat-related regions, notably bed nucleus stria terminalis anterior insula. Posterior cingulate cortex, posterior possibly medial frontal gyrus showed increased during control stressor. Our findings support idea aversiveness reduced when controllable, leading key involved anxiety-related processing, even extended amygdala.

Language: Английский

Citations

43
Threat and Reward Imminence Processing in the Human Brain DOI Creative Commons
Dinavahi V. P. S. Murty, Songtao Song, Srinivas Govinda Surampudi

et al.

Journal of Neuroscience, Journal Year: 2023, Volume and Issue: 43(16), P. 2973 - 2987

Published: March 16, 2023

In the human brain, aversive and appetitive processing have been studied with controlled stimuli in rather static settings. addition, extent to which aversive-related appetitive-related engage distinct or overlapping circuits remains poorly understood. Here, we sought investigate dynamics of while male female participants engaged comparable trials involving threat avoidance reward seeking. A central goal was characterize temporal evolution responses during periods imminence. For example, domain, predicted that bed nucleus stria terminalis (BST), but not amygdala, would exhibit anticipatory given role former anxious apprehension. We also periaqueductal gray (PAG) threat-proximity based on its involvement proximal-threat processes, ventral striatum threat-imminence escape rodents. Overall, uncovered imminence-related temporally increasing ("ramping") multiple brain regions, including BST, PAG, striatum, subcortically, dorsal anterior insula midcingulate, cortically. Whereas generated proximity as expected, it exhibited threat-related imminence responses. fact, across observed a main effect arousal. other words, extensive evolving, both suggesting distributed are dynamically biologically relevant information regardless valence, findings further supported by network analysis.

Language: Английский

Citations

21