Electroacupuncture Regulates Cannabinoid Receptor 1 Expression in a Mouse Fibromyalgia Model: Pharmacological and Chemogenetic Modulation DOI Creative Commons
Yu-An Yeh, Hsin‐Cheng Hsu,

Ming‐Chia Lin

et al.

Life, Journal Year: 2024, Volume and Issue: 14(11), P. 1499 - 1499

Published: Nov. 17, 2024

Fibromyalgia is a chronic illness usually accompanied by long-lasting, general pain throughout the body, often anxiety, depression, fatigue, and sleep disruption. Meanwhile, doctors scientists have not entirely discovered detailed mechanisms; patients always an exaggerated sensation to pervasive without satisfied medical service. Given lack of knowledge on its underlying mechanism, current treatments aim provide and/or symptom relief. The present study aimed clarify role cannabinoid receptor 1 (CB1) signaling in mouse fibromyalgia model. To develop model, mice were subjected intermittent cold stress (ICS). Our results indicated that mechanical (2.09 ± 0.09 g) thermal hyperalgesia (4.77 0.29 s), which evaluated von Frey Hargraves’ tests, induced ICS, suggesting successful modeling. hurting replies then provoked electroacupuncture (EA) but for sham EA mice. Further, Western blot analysis, we found significantly decreased CB1 protein levels thalamus, somatosensory cortex, anterior cingulate cortex. In addition, pain-related kinases transcription factor increased. Treatment with reliably increased expression various brain regions sequentially alleviated nociceptive mediators. Furthermore, administration agonist attenuated pain, reversed analgesia antagonist, further chemogenetic inhibition SSC. innovative findings evidence interaction fibromyalgia, potential clinical trials as treatment target.

Language: Английский

Midbrain glutamatergic circuit mechanism of resilience to socially transferred allodynia in male mice DOI Creative Commons
Yi Han, Lin Ai, Lingzhen Song

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: June 10, 2024

Language: Английский

Citations

14
The psychophysiology of music-based interventions and the experience of pain DOI Creative Commons
Carolyn Arnold, Matthew K. Bagg,

Alan R. Harvey

et al.

Frontiers in Psychology, Journal Year: 2024, Volume and Issue: 15

Published: May 10, 2024

In modern times there is increasing acceptance that music-based interventions are useful aids in the clinical treatment of a range neurological and psychiatric conditions, including helping to reduce perception pain. Indeed, belief music, whether listening or performing, can alter human pain experiences has long history, dating back ancient Greeks, its potential healing properties have been appreciated by indigenous cultures around world. The subjective experience acute chronic complex, influenced many intersecting physiological psychological factors, it therefore be expected impact music therapy on may vary from one situation another, person another. Where persists becomes chronic, aberrant central processing key feature associated with ongoing experience. Nonetheless, beneficial effects exposure relief reported across wide shown effective neonates, children adults. this comprehensive review we examine various neurochemical, factors underpin experience, potentially operate at levels – periphery, spinal cord, brainstem, limbic system multiple areas cerebral cortex. We discuss extent which these individually combination, influence how affects both quality intensity pain, noting remains controversy about respective roles diverse peripheral processes play Better understanding mechanisms underlie music’s together insights into should aid developing more synergistic approaches when combined treatments. ubiquitous nature also facilitates application therapeutic environment daily life, for individual social benefit.

Language: Английский

Citations

10
Pituitary adenylate cyclase‐activating polypeptide (PACAP)overexpression in the paraventricular nucleus of the thalamus alters motivated and affective behavior in female rats DOI

Brody A. Carpenter,

Breanne E. Pirino,

Malcolm C. Jennings

et al.

Alcohol Clinical and Experimental Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Abstract Background Pituitary adenylate cyclase‐activating polypeptide (PACAP) has been found to be involved in a wide range of motivated and affective behaviors. While the PACAP‐38 isoform is more densely expressed than PACAP‐27 most brain, highly rodent paraventricular nucleus thalamus (PVT), where females also have greater expression males. Notably, role cells PVT not explored. Methods Adult, female Long‐Evans rats were injected with an adeno‐associated virus (AAV) increase PACAP or control AAV. They then investigated for subsequent ethanol drinking preference; sucrose locomotor activity novel chamber, behavior light–dark box, novelty suppression feeding test, familiar forced swim test. Results Injection AAV resulted specific levels PACAP‐27. Rats demonstrated reduced preference under intermittent‐access procedure compared those In contrast, showed no significant difference sucrose, any tested, except that they spent less time swimming Conclusions light low overall level ability drinking, minimal effects on other behaviors, supports idea compounds related should as potential therapeutics treatment alcohol use disorder.

Language: Английский

Citations

1
Perioperative esketamine combined with butorphanol versus butorphanol alone for pain management following video-assisted lobectomy: a randomized controlled trial DOI
Hongjian Wang, Zicheng Wang, Junbao Zhang

et al.

International Journal of Clinical Pharmacy, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Language: Английский

Citations

1
Selective activation of SIGMAR1 in anterior cingulate cortex glutamatergic neurons facilitates comorbid pain in depression in male mice DOI Creative Commons

Xianlei Wang,

Shulin Wu,

Jiawei Zuo

et al.

Communications Biology, Journal Year: 2025, Volume and Issue: 8(1)

Published: Jan. 31, 2025

Depression and comorbid pain are frequently encountered clinically, the comorbidity complicates overall medical management. However, mechanism whereby depression triggers development of needs to be further elucidated. Here, by using chronic restraint stress (CRS) mouse model pain, we showed that CRS hyperactivated glutamatergic neurons in anterior cingulate cortex (ACC), as well increasing dendrite complexity number. Chemogenetic activation these can induce while chemogenetic blockade reverse such depression-induced pain. Moreover, utilized translating ribosome affinity purification (TRAP) combination with c-Fos-tTA strategy pharmacological approaches identified SIGMAR1 a potential therapeutic molecular target. These results revealed previously unknown neural for provided new mechanistic insights into antidepressive analgesic effects disease.

Language: Английский

Citations

0
Prevalence of Depressive Disorders in Operatively Treated Pelvic Trauma Patients DOI Creative Commons
Piotr Walus, Jakub Ohla,

Rafał Wójcicki

et al.

Diseases, Journal Year: 2025, Volume and Issue: 13(4), P. 105 - 105

Published: March 31, 2025

Aim: The aim of this study is to assess the prevalence depressive disorders in patients with pelvic fractures treated surgically at our center years 2017–2022. Materials and Methods: included 75 patients, 57 men 18 women, operated on 2017–2022 due acetabular fracture ring injury. Factors such as age, gender, chronic pain measured VAS scale, incidence suicidal thoughts were also analyzed. participants completed Beck Depression Inventory (BDI). Results: Thirty-five out seventy-five showed symptoms depression (BDI score > 11), which 47%, an average 29 (p < 0.0001). Women obtained BDI 23, corresponds moderate Beck’s scale 0.008). correlation between trauma has been found be positive 0.0003; r = 0.4094). Furthermore, women studied population reported more often than (44% vs. 14%; p 0.01). No statistically significant was occurrence length hospital stay patient’s age 0.5 0.06, respectively). Conclusions: determined 47%.

Language: Английский

Citations

0
The association between traumatic temporomandibular joint bony ankylosis and depressive disorder in growing rats DOI Creative Commons

Tiange Deng,

Yang Xue, Yiming Wang

et al.

BMC Oral Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 11, 2025

The psychological symptoms of temporomandibular joint (TMJ) ankylosis were similar to that depressive disorder, but there no relevant evidences confirm the humans or animals with TMJ had disorder. aim this study was investigate association between and disorder in rat model. Thirty 3-week-old male Sprague-Dawley (SD) rats used study. damage complexes narrowed space performed unilateral test group induce bony (experimental side). other underwent a sham operation (sham TMJs control did not undergo any operations. At 8 weeks postoperatively, behavioral tests, body weight, passive maximum mouth opening (PMMO), morphological features evaluated, hippocampuses analyzed using western blotting immunocytochemistry. data compared by independent t-test, experimental side paired t-test. correlations PMMO/area fusion duration immobility, sucrose preference, CB1 receptor protein, mean optical density number BrdU-positive cell evaluated linear regression analysis. level significance 0.05. In group, traumatic developed ankylosis, area mass (21.26 mm2) larger than (1.73 (p < 0.001). There significant difference preference (test group: 0.36, 0.76, p 0.001), immobility 127.36 s, 59.41 weight 156.70 g, 270.06 PMMO 9.98 mm, 28.79 protein 41.00%, 86.69%, 29.60 a.u., 54.69 2133.71, 4301.95, negatively correlated (r = 0.953, while positively 0.961, 0.955, 0.976, 0.958, 0.001, all), 0.970, 0.981, 0.971, all). present verified found model ankylosis. severity

Language: Английский

Citations

0
Behavioral outcomes in the bystander and demonstrator male mice following a socially-transferred allodynia paradigm DOI

Sha Sha,

Moruo Zhang,

Ting Ge

et al.

Physiology & Behavior, Journal Year: 2025, Volume and Issue: unknown, P. 114880 - 114880

Published: March 1, 2025

Language: Английский

Citations

0
The Locus Coeruleus in Chronic Pain DOI Open Access

Jorge Castejón España,

Anusha Mohan, Sven Vanneste

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 8636 - 8636

Published: Aug. 8, 2024

Pain perception is the consequence of a complex interplay between activation and inhibition. Noradrenergic pain modulation inhibits nociceptive transmission perception. The main source norepinephrine (NE) in central nervous system Locus Coeruleus (LC), small but cluster cells pons. aim this study to review literature on LC-NE inhibitory system, its influence chronic pathways frequent comorbidities. research showed that environmental processing modulated by system. If perpetuated time, inputs can generate neuroplastic changes reduce effects facilitate development comorbidities, such as anxiety, depression or sleeping disturbances. exact mechanisms involved LC functional shift remain unknown, there some evidence they occur through plastic medial lateral their brain projections. Additionally, are other influencing factors, like developmental issues, neuroinflammatory glial changes, NE receptor affinity neuronal firing rates.

Language: Английский

Citations

2
Microglial adenosine A2A receptor in the paraventricular thalamic nucleus regulates pain sensation and analgesic effects independent of opioid and cannabinoid receptors DOI Creative Commons
Yiping Cao,

Zhou Wu,

Moruo Zhang

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 19, 2024

The paraventricular thalamic nucleus (PVT) is recognized for its critical role in pain regulation, yet the precise molecular mechanisms involved remain poorly understood. Here, we demonstrated an essential of microglial adenosine A

Language: Английский

Citations

1