Stress dynamically modulates neuronal autophagy to gate depression onset

Nature, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Chronic stress remodels brain homeostasis, in which persistent change leads to depressive disorders1. As a key modulator of homeostasis2, it remains elusive whether and how autophagy is engaged dynamics. Here we discover that acute activates, whereas chronic suppresses, mainly the lateral habenula (LHb). Systemic administration distinct antidepressant drugs similarly restores function LHb, suggesting LHb as common target. Genetic ablation neuronal promotes susceptibility, enhancing exerts rapid antidepressant-like effects. controls excitability, synaptic transmission plasticity by means on-demand degradation glutamate receptors. Collectively, this study shows causal role maintaining emotional homeostasis against stress. Disrupted implicated maladaptation stress, its reversal enhancers provides new strategy.

Language: Английский

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A small population of stress-responsive neurons in the hypothalamus-habenula circuit mediates development of depression-like behavior in mice

Neuron, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

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Launching of a special column on the “Top 10 Academic Advances of Young Scholars at Zhejiang University”

Journal of Zhejiang University. Science A, Journal Year: 2024, Volume and Issue: 25(10), P. 763 - 764

Published: Oct. 1, 2024

Language: Английский

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