Recent Progress in the Pathophysiology and Treatment of FSGS Recurrence

American Journal of Transplantation, Journal Year: 2013, Volume and Issue: 13(2), P. 266 - 274

Published: Jan. 11, 2013

Focal segmental glomerulosclerosis (FSGS) is a glomerular disease characterized by proteinuria, frequent progression to end-stage renal disease, and recurrence after kidney transplantation in ∼25% of patients, which negatively impacts long-term allograft survival. Experimental studies suggest that abnormalities T and, possibly, B cells may represent one initial pathogenic trigger, leading podocyte injury progressive loss. New data also support the existence circulating permeability factors able damage podocytes, but no single molecule has been consistently identified as causal element FSGS recurrence. Unfortunately, major progress from mechanistic not translated into substantial advancements patient treatment, with plasmapheresis (PP) high doses cyclosporine (CsA) remaining mainstays therapy. Despite consistent experimental clinical evidence treatment proteinuria slows function decline proteinuric nephropathies, maximal use antiproteinuric agents such renin angiotensin system antagonists routine management More recently, encouraging results have reported anti-CD20 depleting antibody rituximab, further are needed establish its safety/efficacy profile.

Language: Английский

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The Pathogenesis of Focal Segmental Glomerulosclerosis

Advances in Chronic Kidney Disease, Journal Year: 2014, Volume and Issue: 21(5), P. 408 - 416

Published: Aug. 26, 2014

Language: Английский

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Podocyte repopulation by renal progenitor cells following glucocorticoids treatment in experimental FSGS

AJP Renal Physiology, Journal Year: 2013, Volume and Issue: 304(11), P. F1375 - F1389

Published: March 14, 2013

Prednisone is a mainstay of treatment for patients with focal segmental glomerulosclerosis (FSGS), disease characterized by reduced podocyte number and glomerulosclerosis. Although the systemic immune-modulatory effects prednisone are well-known, direct tissue on glomerular cells poorly understood. Experimental FSGS was induced in mice cytotoxic anti-podocyte antibody, resulting an abrupt decrease day 3, proteinuria, development Administering daily to FSGS, beginning at significantly increased weeks 2 4. Podocyte did not increase control given DMSO. The prednisone-treated correlated apoptosis measured synaptopodin + /caspase-3 double staining. Additionally, progenitors, defined as expressing both parietal epithelial cell protein protein, This associated phospho-ERK staining (PAX2 /p-ERK ) progenitors (WT-1 lining Bowman's capsule). These data show that this model experimental augments repair increasing through cells. limits loss reducing apoptosis, it increases regeneration augmenting progenitors. support action improving outcomes FSGS.

Language: Английский

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Renal Allograft Fibrosis: Biology and Therapeutic Targets

American Journal of Transplantation, Journal Year: 2015, Volume and Issue: 15(4), P. 863 - 886

Published: Feb. 17, 2015

Renal tubulointerstitial fibrosis is the final common pathway of progressive renal diseases. In allografts, it assessed with tubular atrophy as interstitial fibrosis/tubular (IF/TA). IF/TA occurs in about 40% kidney allografts at 3-6 months after transplantation, increasing to 65% 2 years. The origin allograft complex and includes donor-related factors, particular case expanded criteria donors, ischemia-reperfusion injury, immune-mediated damage, recurrence underlying diseases, hypertensive nephrotoxicity immunosuppressants, recurrent graft infections, postrenal obstruction, etc. Based largely on studies non-transplant setting, there a large body literature role different cell types, be intrinsic or bone marrow derived, mediating fibrosis, number mediator systems contributing fibrotic changes growing steadily. Here we review most important cellular processes mediators involved progress focus situation, discuss some challenges translating experimental insights into clinical trials, biomarkers imaging modalities.

Language: Английский

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Knowledge Domain and Emerging Trends in Podocyte Injury Research From 1994 to 2021: A Bibliometric and Visualized Analysis

Frontiers in Pharmacology, Journal Year: 2021, Volume and Issue: 12

Published: Dec. 3, 2021

Background: Podocyte injury has a direct causal relationship with proteinuria and glomerulosclerosis and, on chronic level, can lead to irreversible disease progression. plays critically decisive role in the development of proteinuric kidney disease. In recent years, research podocyte developed rapidly all over world. However, no report summarized field as whole date. Using bibliometric analysis, this study aimed evaluate current state worldwide last 30 years identify important achievements, primary fields, emerging trends. Methods: Publications related were retrieved from Web Science Core Collection. HistCite, VOSviewer, CiteSpace, Bibliometrix Package used for analysis visualization, including overall distribution annual outputs, leading countries, active institutions authors, core journals, co-cited references, keywords. Total global citation score total local assess quality impact publications. Results: A 2,669 publications identified. tended increase continuously. 10,328 authors 2,171 69 countries published studies injury. China (39.46%) was most prolific country, number citations United States (cited 36,896 times) ranked first. Moin Saleem, John Cijiang He, Zhihong Liu top three contributing Journal American Society Nephrology Kidney International popular journals field. "Diabetic nephropathy" is focus area research, "autophagy," "microRNA," "inflammation" keywords hotspots, traditional Chinese medicine monomer may be neglected gap. Conclusion: Our found that have increased dramatically. Diabetic nephropathy main injury, whereas autophagy, microRNA, inflammation are topics getting attention scholars which become next research.

Language: Английский

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