Postoperative Atrial Fibrillation: A Review

Biomedicines, Journal Year: 2024, Volume and Issue: 12(9), P. 1968 - 1968

Published: Sept. 1, 2024

Atrial fibrillation (AF) in the postoperative phase is a manifestation of numerous factors, including surgical stress, anesthetic effects, and underlying cardiovascular conditions. The resultant cardiac hyperactivity can induce new onset or exacerbate existing AF. A common phenomenon, atrial (POAF) affects nearly 40% patients associated with longer hospitalization stays, increased mortality, heart failure, stroke, healthcare costs. Areas controversy POAF include whether to anticoagulate who have short-lived POAF, especially given their higher bleeding risk period, identification would benefit most from preventive drug therapy for POAF. This review discusses pathophysiology management strategies reduce its occurrence.

Language: Английский

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Prognostic value of the preoperative echocardiography indicators in the development of atrial fibrillation after aortic valve replacement

Reports of Vinnytsia National Medical University, Journal Year: 2024, Volume and Issue: 28(3), P. 473 - 478

Published: Sept. 25, 2024

Annotation. Postoperative atrial fibrillation (POAF) is the most common and significant complication that occurs after various types of open heart surgery, in particular, more than half cases patients aortic valve replacement, which leads to an increase morbidity, mortality, length stay hospitalization financial costs. POAF can lead development stroke, thromboembolism, cardiac arrest, increased risk death. The issue occurrence predictors replacement have not been fully studied. aim identify analyze probable based on study preoperative echocardiographic parameters. included 244 (158 men, 86 women) aged from 27 83 years (average - 60.94±10.92 years), who underwent replacement. All them were divided into two groups: group I consisted 102 with AF developed postoperative period, II – 142 without POAF. A comparative assessment demographic, general clinical, instrumental electrophysiological indicators was conducted. out 41.8% first experimental group). By ROC analysis, cut-off levels for predicting calculated: diameter left atrium (AUROC 0.594; 95% CI 0.52-0.67) at optimal distribution point >4.55 cm has a sensitivity 49 %, specificity 57.7%); volume 0.673; 0.6-0.74) level >87.5 cm3 61.2%, 60.9%; end-diastolic size ventricle 0.658; 0.51-0.81) >5.8 67.7%, 77.8%). Against background conducted research, it established factors are: bicuspid structure valve, II-III stage mitral insufficiency, 4.55 cm, 87.5 5.8 cm. revealed will allow developing prognostic model risks, as well effective strategy prevention rhythm disorders this category patients.

Language: Английский

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Innovative Epicardial Bigels Containing Amiodarone Hydrochloride: Pharmacotechnical and Analytical Characterization

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(11), P. 1511 - 1511

Published: Nov. 9, 2024

The search for novel ways of providing treatment also targets the development formulations used in drug delivery. Among important characteristics pharmaceutical gels are their ability to penetrate membranes, capability offer rapid response, and capacity avoid hepatic metabolization route followed by many drugs. Bigels combine advantages both hydrogels oleogels, creating a biphasic system that might improve solubility amiodarone water, which is otherwise poorly soluble. This study aimed succeed formulating stable hydrochloride bigels (coded from ABG1-ABG6) destined atrial application evaluating them pharmacotechnical perspective.

Language: Английский

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Machine learning is more accurate and biased than risk scoring tools in the prediction of postoperative atrial fibrillation after cardiac surgery

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 7, 2024

Abstract Incidence of postoperative atrial fibrillation (POAF) after cardiac surgery remains high and is associated with adverse patient outcomes. Risk scoring tools have been developed to predict POAF, yet discrimination performance moderate. Machine learning (ML) models can achieve better but may exhibit heterogeneity across race sex subpopulations. We evaluate 8 risk 6 ML on a heterogeneous cohort derived from electronic health records. Our results suggest that higher are less fair, especially respect race. findings highlight the need for building accurate fair facilitate consistent equitable assessment POAF risk.

Language: Английский

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Efficacy and safety of sacubitril/valsartan on postoperative atrial fibrillation in adult patients undergoing cardiac surgery: a real-world observational study

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Nov. 20, 2024

The mechanism underlying new-onset postoperative atrial fibrillation (POAF) in adult cardiac surgery is not well understood. However, efficient pharmacological methods to prevent and treat arrhythmic complications are still lacking. In the present study, we explored efficacy safety of sacubitril/valsartan (sac/val) control POAF patients.

Language: Английский

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New postoperative atrial fibrillation after cardiac surgery: Revealing new risk factors

Journal of Clinical Anesthesia, Journal Year: 2024, Volume and Issue: 100, P. 111684 - 111684

Published: Nov. 27, 2024

Language: Английский

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