A review of biological targets and therapeutic approaches in the management of triple-negative breast cancer

Journal of Advanced Research, Journal Year: 2023, Volume and Issue: 54, P. 271 - 292

Published: Feb. 14, 2023

Triple-negative breast cancer (TNBC) is a heterogeneous, aggressive phenotype of with associated chemoresistance. The development chemo- or radioresistance could be attributed to diverse tumor microenvironments, overexpression membrane proteins (transporters), epigenetic changes, and alteration the cell signaling pathways/genes stem cells (CSCs). Due heterogeneous nature TNBC, therapeutic response existing modalities offers limited scope thus results in reccurance after therapy. To establish landmark efficacy, number novel have been proposed. In addition, reversal resistance that developed during treatment may altered by employing appropriate modalities. This review aims discuss plethora investigations carried out, which will help readers understand make an choice therapy directed toward complete elimination TNBC. manuscript addresses major contributory factors from microenvironment are responsible for chemoresistance poor prognosis. cellular events molecular mechanism-based interventions explained detail. Inhibition ABC transporters, pathways CSCs, modification promising this regard. TNBC progression, invasion, metastasis recurrence can also inhibited blocking multiple pathways, targeting specific receptors/epigenetic targets, disrupting bioenergetics generating reactive oxygen species (ROS).

Language: Английский

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Tumor dormancy and relapse: understanding the molecular mechanisms of cancer recurrence

Military Medical Research, Journal Year: 2025, Volume and Issue: 12(1)

Published: Feb. 11, 2025

Abstract Cancer recurrence, driven by the phenomenon of tumor dormancy, presents a formidable challenge in oncology. Dormant cancer cells have ability to evade detection and treatment, leading relapse. This review emphasizes urgent need comprehend dormancy its implications for recurrence. Despite notable advancements, significant gaps remain our understanding mechanisms underlying lack reliable biomarkers predicting provides comprehensive analysis cellular, angiogenic, immunological aspects dormancy. It highlights current therapeutic strategies targeting dormant cells, particularly combination therapies immunotherapies, which hold promise preventing By elucidating these proposing innovative research methodologies, this aims deepen ultimately facilitating development more effective recurrence improving patient outcomes.

Language: Английский

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ST6Gal1: Oncogenic signaling pathways and targets

Frontiers in Molecular Biosciences, Journal Year: 2022, Volume and Issue: 9

Published: Aug. 29, 2022

The Golgi-sialyltransferase ST6Gal1 (βgalactosidase α2,6 sialyltransferase 1), adds the negatively charged sugar, sialic acid, to terminal galactose of N-glycosylated proteins. Upregulation is observed in many malignancies, and a large body research has determined that ST6Gal1-mediated sialylation impacts cancer hallmarks. affects oncogenic behaviors including sustained proliferation, enhanced self-renewal, epithelial-to-mesenchymal transition, invasion, chemoresistance. However, there are relatively few ST6GaL1 related signaling pathways well-established mediate these biologies: greater delineation specific targets mechanisms orchestrated by needed. aim this review provide summary our current understanding select affected ST6Gal1.

Language: Английский

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A spotlight on the interplay between Wnt/β-catenin signaling and circular RNAs in hepatocellular carcinoma progression

Frontiers in Oncology, Journal Year: 2023, Volume and Issue: 13

Published: July 21, 2023

Hepatocellular carcinoma (HCC) is one of the deadliest cancers due to multifocal development and distant metastasis resulting from late diagnosis. Consequently, new approaches HCC diagnosis treatment are required reduce mortality rates. A large body evidence suggests that non-coding RNAs (ncRNAs) important in cancer initiation progression. Cancer cells release many these ncRNAs into blood or urine, enabling their use as a diagnostic tool. Circular (CircRNAs) members regulate cell expansion, migration, metastasis, chemoresistance through different mechanisms such Wnt/β-catenin Signaling pathway. The pathway plays prominent roles several biological processes including organogenesis, stem regeneration, survival. Aberrant signaling both pathways mentioned above could affect progression cancers, HCC. Based on studies investigated current review, circRNAs have an effect formation by sponging miRNAs RNA-binding proteins (RBPs) regulating Therefore, circRNAs/miRNAs RBPs/Wnt/β-catenin be considered promising prognostic therapeutic targets

Language: Английский

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Nanomedicine Technologies for Diagnosis and Treatment of Breast Cancer

ACS Pharmacology & Translational Science, Journal Year: 2023, Volume and Issue: 6(5), P. 671 - 682

Published: April 21, 2023

Breast cancer is one of the most common cancers in women worldwide, yet conventional treatments have several shortcomings, including low specificity, systemic toxicity, and drug resistance. Nanomedicine technologies provide a promising alternative while also overcoming limitations posed by therapies. This mini-Review highlights important signaling pathways related to occurrence development breast current therapies, followed an analysis various nanomedicine developed for diagnosis treatment cancers.

Language: Английский

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The interaction of Notch and Wnt signaling pathways in vertebrate regeneration

Cell Regeneration, Journal Year: 2021, Volume and Issue: 10(1)

Published: April 1, 2021

Abstract Regeneration is an evolutionarily conserved process in animal kingdoms, however, the regenerative capacities differ from species and organ/tissues. Mammals possess very limited potential to replace damaged organs, whereas non-mammalian usually have impressive abilities regenerate organs. The regeneration requires proper spatiotemporal regulation key signaling pathways. canonical Notch Wnt pathways, two fundamental signals guiding development, been demonstrated play significant roles of vertebrates. In recent years, increasing evidence has implicated cross-talking between during organ regeneration. this review, we summarize several representative events, emphasizing functions molecular bases their interplay these processes, shedding light on utilizing pathways enhance mammals design legitimate therapeutic strategies.

Language: Английский

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Wnt Pathway Extracellular Components and Their Essential Roles in Bone Homeostasis

Genes, Journal Year: 2022, Volume and Issue: 13(1), P. 138 - 138

Published: Jan. 13, 2022

The Wnt pathway is involved in several processes essential for bone development and homeostasis. For proper functioning, the tightly regulated by numerous extracellular elements that act both activating inhibiting at different moments. This review aims to describe, summarize update findings regarding modulators of pathway, including co-receptors, ligands inhibitors, relation homeostasis, with an emphasis on animal models generated, diseases associated each gene which member involved. precise knowledge all these will help us identify possible targets can be used as a therapeutic target treatment such osteoporosis.

Language: Английский

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Lung Cancer Gene Regulatory Network of Transcription Factors Related to the Hallmarks of Cancer

Current Issues in Molecular Biology, Journal Year: 2023, Volume and Issue: 45(1), P. 434 - 464

Published: Jan. 5, 2023

The transcriptomic analysis of microarray and RNA-Seq datasets followed our own bioinformatic pipeline to identify a transcriptional regulatory network lung cancer. Twenty-six transcription factors are dysregulated co-expressed in most the cancer pulmonary arterial hypertension datasets, which makes them frequently factors. Co-expression, gene regulatory, coregulatory, networks, along with fibration symmetries, were constructed common connection patterns, alignments, main regulators, target genes order analyze factor complex formation, as well its synchronized co-expression patterns every type function over deregulated was validated ChEA3 enrichment analysis. A Kaplan-Meier plotter linked dysregulation top patients' survival. Our results indicate that has unique hypertension, regulated coordinated cooperative manner by might be associated critical biological processes signaling pathways related acquisition hallmarks cancer, making potentially relevant tumor biomarkers for early diagnosis targets development personalized therapies against

Language: Английский

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ATF4 promotes lung cancer cell proliferation and invasion partially through regulating Wnt/β-catenin signaling

International Journal of Medical Sciences, Journal Year: 2021, Volume and Issue: 18(6), P. 1442 - 1448

Published: Jan. 1, 2021

Activating transcription factor 4 (ATF4) is a member of the cAMP response element binding (CREB) protein family and has been reported to participate in cancer progression; however, its molecular mechanism not fully understood.In this study, we investigated function ATF4 non-small cell lung regulation.We detected cytoplasmic nuclear expression A549, H1299, LK2 cells, total was higher than that HBE cells (p < 0.05).Higher all these compared 0.05).Overexpression A549 significantly promoted growth invasion 0.05).Expression Wnt signaling molecules, including β-catenin, MMP7, cyclin D1, activity canonical were also by 0.05).ICG001, inhibitor selectively inhibits β-catenin/ cyclic adenosine monophosphate (CBP) interaction, inhibited signaling.The ICG001 0.05).However, treatment with ICG001, ability treated both cDNA increased 0.05), which indicates dependent only on Wnt/β-catenin regulation β-catenin affected > 0.05).The promote abolished 0.05).These results indicate may contribute progression at least partly regulating signaling.

Language: Английский

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Reprogramming Glioblastoma Cells into Non-Cancerous Neuronal Cells as a Novel Anti-Cancer Strategy

Cells, Journal Year: 2024, Volume and Issue: 13(11), P. 897 - 897

Published: May 23, 2024

Glioblastoma Multiforme (GBM) is an aggressive brain tumor with a high mortality rate. Direct reprogramming of glial cells to different cell lineages, such as induced neural stem (iNSCs) and neurons (iNeurons), provides genetic tools manipulate cell’s fate potential therapy for neurological diseases. NeuroD1 (ND1) master transcriptional factor neurogenesis it promotes neuronal differentiation. In the present study, we tested hypothesis that expression ND1 in GBM can force them differentiate toward post-mitotic halt progression. cultured human lines, including LN229, U87, U373 temozolomide (TMZ)-sensitive T98G TMZ-resistant cells, lineage conversion was by adeno-associated virus (AAV) package carrying ND1. Twenty-one days after AAV-ND1 transduction, ND1-expressing displayed markers MAP2, TUJ1, NeuN. The ND1-induced transdifferentiation regulated Wnt signaling markedly enhanced under hypoxic condition (2% O2 vs. 21% O2). cultures had fewer BrdU-positive proliferating compared vector control cultures. Increased death visualized TUNEL staining, reduced migrative activity demonstrated wound-healing test both TMZ-sensitive -resistant cells. striking contrast cancer converted expressed anti-tumor gene p53. orthotopical mouse model, AAV-ND1-reprogrammed were transplanted into fornix cyclosporine-immunocompromised C57BL/6 brain. Compared cell-formed tumors, from ND1-reprogrammed formed smaller tumors TUJ1 Thus, using single-factor overcame drug resistance, converting malignant heterogeneous normal neuron-like vitro vivo. These novel observations warrant further research patient-derived xenograft (PDX) models potentially effective treatment deadly likely other astrocytoma tumors.

Language: Английский

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