A life in the shadow of COPD : Symptom burden, caregiver burden and strategies to manage daily life DOI Open Access
H Johansson

Linköping University medical dissertations, Journal Year: 2024, Volume and Issue: unknown

Published: May 7, 2024

Chronic obstructive pulmonary disease (COPD) is an irreversible lung disease.In Sweden, 400,000 to 700,000 individuals are affected by this disease, and it the third most common diagnosis.Among those with COPD, approximately 3% at Global Initiative for Obstructive Lung Disease (GOLD) stages III IV, representing severe disease.Persons COPD have symptoms such as breathing problems, cough, increased mucus production.The persons next of kin life.The person need support from society.All these experiences raise question how healthcare staff can work together help each other when intensify develop self-care strategies avoid emergency care.This would enable a better life, fewer consultations professionals reduced costs.next being informal caregiver be problematic (Suresh 2022).

Language: Английский

Early Integration of Palliative Care in Non-Oncological Patients: A Systematic Review DOI Creative Commons

Joana Rodrigues Mós,

Paulo Reis-Pina

Journal of Pain and Symptom Management, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Recent advances in understanding the role of antidepressants to manage breathlessness in supportive and palliative care DOI
Irene J Higginson, Sabrina Bajwah, Małgorzata Krajnik

et al.

Current Opinion in Supportive and Palliative Care, Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

Purpose of review Breathlessness is a prevalent and distressing symptom in palliative supportive care, with limited licensed pharmacological options once disease-directed therapies are no longer effective. Antidepressants have been proposed as potential treatment, even the absence comorbid mood disorders, due to their modulation neural circuits serotonin pathways involved breathlessness perception. Despite off-label use clinical practice for managing refractory or chronic breathlessness, robust evidence supporting efficacy needed. This critically evaluates latest on benefits safety management. Recent findings influenced by at least three interrelated axes: lung–brain, behavioural–functional, psycho–social–spiritual. These mechanisms operate across diseases, making them relevant care. promise from early case reports small trials, two recent large, randomised studies mirtazapine sertraline found benefit alleviating improving other outcomes. The trial also reported more adverse events than placebo. Earlier trials were design limitations, reducing reliability. A 2016 depression stable COPD. concerns over increased morbidity associated antidepressant respiratory disease highlight need detection people risk worsening holistic, individualised approach. Summary Current does not support antidepressants disease. Non-pharmacological approaches should be first line, given proven low risk. Off-label medicine requires caution ideally offered within evaluation. Given complex nature future research focus innovating then testing treatments well-designed appropriate outcome measures reporting events, health care informal carer effects.

Language: Английский

Citations

0
Ensifentrine: a novel approach to redefining COPD management and implications for additional respiratory diseases DOI
Frank C. Sciurba, Shijing Jia,

Shyam Subramanian

et al.

Expert Opinion on Pharmacotherapy, Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

Ensifentrine, recently approved by the FDA for chronic obstructive pulmonary disease (COPD) maintenance treatment, is a novel inhaled therapy with dual mechanism of action targeting phosphodiesterase (PDE)3 and PDE4. While long-acting bronchodilators corticosteroids remain initial guideline-based COPD treatments, persistent symptoms exacerbations highlight an existing unmet need. Ensifentrine offers both bronchodilator anti-inflammatory benefits, offering potential to address this treatment gap. This article reviews ensifentrine, details supporting preclinical evidence, summarizes key clinical studies. It further explores ensifentrine's impact on landscape its applicability in other diseases. Ensifentrine's offer promising adjunct standard particularly patients despite conventional therapy. improves lung function, meaningfully reduces exacerbation frequency, symptoms, enhances quality life. Its delivery minimizes systemic exposure side effects commonly observed oral PDE inhibitors. Furthermore, properties suggest applications respiratory diseases, such as asthma non-cystic fibrosis bronchiectasis.

Language: Английский

Citations

0
Advances in breathlessness support services for people with serious illness DOI
Naomi Takemura, Matthew Maddocks, Lisa Jane Brighton

et al.

Current Opinion in Supportive and Palliative Care, Journal Year: 2024, Volume and Issue: 18(4), P. 199 - 205

Published: Sept. 16, 2024

Purpose of review Breathlessness remains a common and distressing symptom among people with serious illness, particularly in advanced disease. This synthesises recent advances the development, characteristics, outcomes breathlessness support services. Recent findings The expanding body evidence regarding services has broadened strengthened our understanding clinical cost-effectiveness. expansion these services, into diverse settings including digital delivery, augmented their reach accessibility to wider population. Additionally, there is increasing attention psychological aspects its management, challenges optimising for long-term benefit. Summary studies have made substantial progress enhancing knowledge impact on illness. Innovations extending new countries settings, use platforms intervention plus increased recognition mechanisms, potential more illness live as best possible breathlessness.

Language: Английский

Citations

2
Palliative Care Needs of Women With Advanced Chronic Obstructive Pulmonary Disease DOI

Jessica Madiraca,

Kathleen O. Lindell, Shannon Phillips

et al.

Journal of Hospice and Palliative Nursing, Journal Year: 2024, Volume and Issue: 26(5), P. E154 - E162

Published: July 16, 2024

Individuals with chronic obstructive pulmonary disease (COPD) experience high symptom burden, severe illness, and frequent deterioration in quality of life. Women COPD represent a unique population potential unmet care needs yet remain underrepresented palliative (PC) literature. The purpose this study was to investigate specific women COPD, learn how symptoms impact women, explore factors related PC knowledge, access, barriers. A total 30 individuals were enrolled prospective, single-arm multimethod study, using an adapted Maslow's hierarchy framework. Fifteen participated semistructured interviews. advanced identified barriers including access medications/oxygen resources (pulmonary rehabilitation/support groups), information about disease/treatment, effect weather conditions on symptoms. Some participants not under the direct pulmonologist but recognized importance their services. None had been referred or received PC. This provides evidence that have needs, uncertainty. should opportunity supportive offers. Palliative hospice nurses opportunities address increased

Language: Английский

Citations

1
Management Reality of Female Patients with COPD: A Multicenter Cross-Sectional CAP Study in Japan DOI Creative Commons
T. Yamamoto, Keiji Oishi,

Syuichiro Ohata

et al.

International Journal of COPD, Journal Year: 2024, Volume and Issue: Volume 19, P. 1123 - 1130

Published: May 1, 2024

Background: Reports from Europe and North America suggest that female chronic obstructive pulmonary disease (COPD) patients have a higher symptom burden mortality than male patients. However, little is known about the management reality of with COPD in Japan. Patients Methods: We compared clinical characteristics those using cohort Assessment Practice study, which cross-sectional multicenter observational study. Results: Of 1168 patients, 133 (11.4%) were female. A history never smoking was females males (p< 0.01). Although there no difference age or forced expiratory volume one second (FEV 1 ) % predicted between groups, modified medical research council dyspnea scale (mMRC) number frequent exacerbators (mMRC≥ 2: p< 0.01; exacerbations≥ p=0.011). The mean vital capacity FEV values lower 0.0001 0.0001, respectively). Females more likely to use long-term oxygen therapy inhaled corticosteroids (p=0.016 0.01, prevalence Global Initiative for Chronic Obstructive Lung Disease (GOLD) groups B, C, D (ABCD GOLD 2017 classification), E (ABE 2023 classification) males. Conclusion: Japan, suggesting importance interventions considering female-dominant features such as absolute FVC , respiratory failure, asthma-like conditions. Keywords: disease, exacerbation, subjective symptoms, gender difference, study

Language: Английский

Citations

1
Gender-specific aspects of pulmonary diseases: rehabilitation DOI

A. Rembert Koczulla,

Tessa Schneeberger, Rainer Gloeckl

et al.

Zeitschrift für Pneumologie, Journal Year: 2024, Volume and Issue: 21(3), P. 182 - 188

Published: May 1, 2024

Citations

0
A life in the shadow of COPD : Symptom burden, caregiver burden and strategies to manage daily life DOI Open Access
H Johansson

Linköping University medical dissertations, Journal Year: 2024, Volume and Issue: unknown

Published: May 7, 2024

Chronic obstructive pulmonary disease (COPD) is an irreversible lung disease.In Sweden, 400,000 to 700,000 individuals are affected by this disease, and it the third most common diagnosis.Among those with COPD, approximately 3% at Global Initiative for Obstructive Lung Disease (GOLD) stages III IV, representing severe disease.Persons COPD have symptoms such as breathing problems, cough, increased mucus production.The persons next of kin life.The person need support from society.All these experiences raise question how healthcare staff can work together help each other when intensify develop self-care strategies avoid emergency care.This would enable a better life, fewer consultations professionals reduced costs.next being informal caregiver be problematic (Suresh 2022).

Language: Английский

Citations

0