High-Fat Diet, Epigenetics, and Atherosclerosis: A Narrative Review DOI Open Access
Vikrant Rai

Nutrients, Journal Year: 2024, Volume and Issue: 17(1), P. 127 - 127

Published: Dec. 31, 2024

Atherosclerosis is a chronic inflammatory disease developing and progressing in the presence of risk factors including hyperlipidemia, hypercholesterolemia, inflammation, among others. commonly precipitates as ischemic events, transient attacks, myocardial infarction. Saturated fatty acids are factors; however, their association with epigenetics pathophysiology atherosclerosis not clearly understood. The preclinical clinical trials associating scarcely documented, most studies reported use drugs inhibiting methylation histone modification to improve atherosclerosis. This narrative review aims discuss various aspects between high-fat diet, epigenetic reprogramming, A literature search keywords epigenetics, atherosclerosis, alone or combination, was conducted for articles English language. Duplicate were removed, related subject this article included review. suggests that diet saturated factor but multifactorial, play critical role. However, connecting link underlying molecular cellular mechanisms understood yet warrant more research. rich involving reprogramming altered gene expression. existing support role reversing it using attenuate definitive evidence warrants larger trials. Further, pregnant mothers can manifest cardiovascular offspring; caution must be taken nutrients.

Language: Английский

Metabolic and epigenetic regulation of macrophage polarization in atherosclerosis: molecular mechanisms and targeted therapies DOI Creative Commons

Pinglian Yang,

X. Rong,

Zhuo Gao

et al.

Pharmacological Research, Journal Year: 2025, Volume and Issue: 212, P. 107588 - 107588

Published: Jan. 7, 2025

Atherosclerosis, a multifactorial progressive inflammatory disease, is the common pathology underlying cardiovascular and cerebrovascular diseases. The macrophage plasticity involved in pathogenesis of atherosclerosis. With advance metabolomics epigenetics, metabolites/metabolic epigenetic modification such as DNA methylation, histone noncoding RNA, play crucial role polarization progression Herein, we provide comprehensive review essential metabolic regulation, well crosstalk between two regulating We also highlight potential therapeutic strategies via modifications for atherosclerosis, offer recommendations to our knowledge roles metabolic-epigenetic context Fundamental studies that elucidate mechanisms by which regulation influence atherosclerosis will pave way novel approaches.

Language: Английский

Citations

3
High-Fat Diet, Epigenetics, and Atherosclerosis: A Narrative Review DOI Open Access
Vikrant Rai

Nutrients, Journal Year: 2024, Volume and Issue: 17(1), P. 127 - 127

Published: Dec. 31, 2024

Atherosclerosis is a chronic inflammatory disease developing and progressing in the presence of risk factors including hyperlipidemia, hypercholesterolemia, inflammation, among others. commonly precipitates as ischemic events, transient attacks, myocardial infarction. Saturated fatty acids are factors; however, their association with epigenetics pathophysiology atherosclerosis not clearly understood. The preclinical clinical trials associating scarcely documented, most studies reported use drugs inhibiting methylation histone modification to improve atherosclerosis. This narrative review aims discuss various aspects between high-fat diet, epigenetic reprogramming, A literature search keywords epigenetics, atherosclerosis, alone or combination, was conducted for articles English language. Duplicate were removed, related subject this article included review. suggests that diet saturated factor but multifactorial, play critical role. However, connecting link underlying molecular cellular mechanisms understood yet warrant more research. rich involving reprogramming altered gene expression. existing support role reversing it using attenuate definitive evidence warrants larger trials. Further, pregnant mothers can manifest cardiovascular offspring; caution must be taken nutrients.

Language: Английский

Citations

1