BIO Integration,
Journal Year:
2025,
Volume and Issue:
6(1)
Published: Jan. 1, 2025
Pulmonary
fibrosis
(PF)
is
a
progressive
interstitial
lung
disease
characterized
by
excessive
extracellular
matrix
deposition
and
tissue
scarring,
leading
to
impaired
function
respiratory
failure.
Although
current
treatments,
such
as
pirfenidone
nintedanib,
slow
progression,
they
fail
completely
halt
or
reverse
fibrosis.
Therefore,
innovative
therapeutic
strategies
are
needed.
Targeted
drug
delivery
systems
(TDDSs)
emerging
promising
solutions.
Biomaterials
play
critical
roles
in
these
enhancing
specificity,
availability,
efficacy,
while
minimizing
systemic
toxicity.
The
most
notable
biomaterials
include
nanotechnology-based
systems,
including
liposomes
polymeric
nanoparticles,
which
facilitate
penetration
release
fibrotic
tissues.
Hydrogels
have
three-dimensional
structures
providing
controlled
sustained
at
inflammation
sites,
therefore
particularly
valuable
PF
treatment.
Furthermore,
biological
carriers
stem
cells
vesicles
biocompatibility
anti-inflammatory
effects
that
improve
outcomes.
Despite
the
potential
of
clinical
translation
hindered
several
challenges,
immune
clearance,
stability
platforms,
optimization
retention
within
diseased
Interdisciplinary
approaches
integrating
precision
medicine
with
advancements
may
provide
solutions
opening
new
avenues
for
This
review
discusses
developments
targeted
PF,
emphasizing
importance
biomaterials,
mechanisms
barriers
involved
pulmonary
delivery,
future
perspectives
overcoming
limitations.
ultimate
goal
patient
outcomes
revolutionizing
approach
treatment
through
advanced
technologies.
RSC Advances,
Journal Year:
2025,
Volume and Issue:
15(15), P. 11587 - 11616
Published: Jan. 1, 2025
Iron-oxide
nanoparticles
(IONPs)
have
garnered
substantial
attention
in
both
research
and
technological
domains
due
to
their
exceptional
chemical
physical
properties.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(8), P. 1848 - 1848
Published: April 18, 2024
In
recent
years,
the
frequency
of
strokes
has
been
on
rise
year
by
and
become
second
leading
cause
death
around
world,
which
is
characterized
a
high
mortality
rate,
recurrence
disability
rate.
Ischemic
account
for
large
percentage
strokes.
A
reperfusion
injury
in
ischemic
complex
cascade
oxidative
stress,
neuroinflammation,
immune
infiltration,
mitochondrial
damage.
Conventional
treatments
are
ineffective,
presence
blood–brain
barrier
(BBB)
leads
to
inefficient
drug
delivery
utilization,
so
researchers
turning
their
attention
nano-drug
systems.
Functionalized
systems
have
widely
studied
applied
study
cerebral
diseases
due
favorable
biocompatibility,
efficiency,
strong
specificity,
specific
targeting
ability.
this
paper,
we
briefly
describe
pathological
process
injuries
focus
therapeutic
research
progress
strokes,
aiming
provide
certain
references
understand
(NDDSs).
Innovative Biosystems and Bioengineering,
Journal Year:
2024,
Volume and Issue:
8(1), P. 3 - 18
Published: Jan. 22, 2024
Among
nanoparticles
(NPs)
of
metal
oxides,
magnetite
NPs
are
the
most
well-known.
The
need
for
regulations
related
to
safety
requires
a
deep
understanding
their
toxicological
paradigm.
purpose
presented
review
is
analyze
methods
studying
toxicity
and
summarize
factors
based
on
literature
data.
Literature
sources
were
searched
in
PubMed
database,
99
works
selected,
supplemented
with
articles
from
other
databases
some
cases.
It
shown
that
study
became
widespread
during
last
decade,
reflecting
expansion
list
synthesized
magnetic
awareness
prospects
use
depend
created
nanomaterial.
assessment
cell
lines
popular.
Primitive
more
highly
organized
animals
can
be
used
evaluate
various
aspects
toxicity.
characteristics
(core
composition,
coating,
size,
shape)
mode
application
(concentration,
dose,
exposure,
type
cells,
or
animal
model).
One
main
mechanisms
nanomagnetite
interference
iron
metabolism
increased
generation
reactive
oxygen
species
leading
disruption
proliferation,
viability,
metabolism.
Thus,
studied
by
at
different
levels
living
systems.
Understanding
nanotoxicity
should
contribute
targeted
design
safe
NPs.
