Bioactive Compounds Protect Mammalian Reproductive Cells from Xenobiotics and Heat Stress-Induced Oxidative Distress via Nrf2 Signaling Activation: A Narrative Review

Antioxidants, Journal Year: 2024, Volume and Issue: 13(5), P. 597 - 597

Published: May 13, 2024

Oxidative stress occurs when there is an imbalance between the production of reactive oxygen species (ROS) and body’s antioxidant defenses. It poses a significant threat to physiological function reproductive cells. Factors such as xenobiotics heat can worsen this stress, leading cellular damage apoptosis, ultimately decreasing efficiency. The nuclear factor erythroid 2–related 2 (Nrf2) signaling pathway plays crucial role in defending against oxidative protecting cells via enhancing responses. Dysregulation Nrf2 has been associated with infertility suboptimal performance mammals. Recent advancements therapeutic interventions have underscored critical mitigating restoring functional integrity In narrative review, we delineate harmful effects xenobiotic-induced on explain how provides protection these challenges. studies shown that activating using various bioactive compounds ameliorate distress apoptosis mammalian By comprehensively analyzing existing literature, propose key target for caused by exposure xenobiotic stress. Additionally, based synthesis findings, discuss potential therapies focused improve

Language: Английский

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Sodium benzoate exposure from juvenile to peripubertal period disrupts HPG-axis in both male and female rats

Toxicological Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Language: Английский

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Vinpocetine Mitigates Methotrexate‐Induced Liver Injury in Rats Through Modulating Intercellular Communication

Journal of Biochemical and Molecular Toxicology, Journal Year: 2025, Volume and Issue: 39(5)

Published: May 1, 2025

ABSTRACT Methotrexate (MTX) has been widely implemented in managing several malignancies, inflammatory conditions such as rheumatic arthritis, and autoimmune illnesses. Hepatotoxicity is a significant side effect of MTX, characterized by increased oxidative stress (OS) inflammation. Vinpocetine (Vinpo) prescription medication with favorable safety profile. It exerts anti‐inflammatory oxidant implications that might be novel candidates for protecting against MTX‐induced hepatotoxicity. This study investigates the therapeutic impact Vinpo MTX‐stimulated liver damage via nuclear factor erythroid 2‐related 2 (Nrf2)/heme oxygenase‐1 (HO‐1) kappa‐light‐chain‐enhancer activated B cells (NF‐κB) pathways. Rats are allocated into three groups: (1) Control (saline); (2) MTX‐control (20 mg/kg; injected once i.p.), (3) + MTX groups. was administered orally 7 days, during which given intraperitoneally at end Day 3. The functions, OS markers, mediators, Nrf2, HO‐1, NF‐κB, apoptotic signals were estimated. lead to enhancement superoxide dismutase (SOD) enzyme activity, elevation glutathione (GSH), hindrance malondialdehyde (MDA). also enhances Nrf2 inhibiting NF‐κB (p65) expression markers. Moreover, therapy, conjunction restores normal histological structure hepatic tissues. Our data suggested preventive toxicity through anti‐oxidative, anti‐inflammatory, activities, mediated Nrf2/HO‐1/Nf‐κB caspase‐3/Bax/Bcl‐2

Language: Английский

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Zinc abates sodium benzoate -induced testicular dysfunction via upregulation of Nrf2/ HO-1/ Nf-κB signaling and androgen receptor gene

Journal of Trace Elements in Medicine and Biology, Journal Year: 2024, Volume and Issue: 86, P. 127505 - 127505

Published: July 26, 2024

Language: Английский

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Zinc Ameliorates Acrylamide-Induced Cognitive Impairment in Male Wistar Rats: Modulation of Oxidative Stress, Neuro-inflammation, and Neurotrophic Pathways

Biological Trace Element Research, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Language: Английский

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