Sciences of Phytochemistry, Journal Year: 2024, Volume and Issue: 3(2), P. 98 - 104
Published: Nov. 9, 2024
Spodoptera frugiperda is an invasive pest causing significant crop losses worldwide. Resistance development and health environmental concerns associated with synthetic insecticides have prompted a search for eco-friendly biopesticides. Limonoids such as salannin, volkensin, volkensinone, isolated from the East African plant Melia volkensii, show antifeedant activity against S. larvae. Volkensin had ED50 of 3.5 µg/cm², volkensinone (a lactone volkensin) 6 salannin 13 µg/cm². Additional limonoids M. including salanninolide toosendanin, also displayed strong effects. With toosendanin already used commercially, re-evaluation volkensii compounds was conducted using in silico techniques. Docking simulations 3D models these ryanodine receptor protein revealed binding affinities -6.4 to -7.5 kcal/mol, comparable those chlorantraniliprole, commercial insecticide targeting receptors. These at two distinct sites align well in-vitro activity, underscoring volkensii’s potential environmentally friendly, receptor-targeted biopesticide frugiperda.
Language: Английский