Published: Jan. 1, 2024
Language: Английский
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 136738 - 136738
Published: Oct. 20, 2024
Language: Английский
Citations
2
BMC Oral Health, Journal Year: 2023, Volume and Issue: 23(1)
Published: Nov. 28, 2023
Abstract Background Treated dentin matrix hydrogel (TDMH) has been introduced as a novel injectable direct pulp capping material. In this regard, study aimed to evaluate its marginal adaptation, physicochemical and rheological properties for the development of clinically feasible TDMH. Methods TDMH was applied floor prepared Class I cavities (n = 5), adaptation assessed by SEM at 1000 X magnification detect gap between filling Five syringes were filled with placed compression plates universal testing machine injectability gelation time also evaluated test vial inverting method. The microstructures lyophilized observed SEM. Moreover, discs 5) water uptake (%) determined based on equilibrium swelling theory state hydrogels. Its solubility measured after one week ISO standard Rheological behaviours analysed rotational rheometer computing their complex shear modulus G* associated storage (G′) loss (G′’). Statistical analysis performed using F (ANOVA) repeated measures Post Hoc Test ( p 0.05). Results presented an overall 92.20 ± 2.95% continuous margins. It exhibited during first minute, mean 66 0.36%. showed highly porous structure, pores interconnected average diameter about 5.09 3.17 μm. Swelling gradually reached 6 days up 377%. hydrogels maintained shape absorbing over three times original weight water. fulfilled requirements 6876, demonstrating 1.98 0.09% linear viscoelastic behaviour G` 479.2 12.7 G`` 230.8 13.8. Conclusions provided good appropriate support use material in future clinical applications.
Language: Английский
Citations
4
Advanced NanoBiomed Research, Journal Year: 2024, Volume and Issue: 4(6)
Published: March 31, 2024
Hydrogels have emerged as a focal point of research in the biomedical field due to their applications tissue repair. However, majority hydrogels lack capability release oxygen, constraining therapeutic outcomes environments with hypoxic tissues. In recent years, oxygen‐releasing garnered extensive attention engineering, owing ability modulate oxygen and meet diverse oxygenation requirements various These can enhance repair efficiency promote regeneration environments. The design primarily involves utilization sources, such algae, perfluorocarbons, peroxides, achieve optimal oxygenation. This review provides comprehensive summary fabrication strategies hydrogels, discusses deeply into underlying mechanisms, myriad along prospective challenges.
Language: Английский
Citations
1
International Journal of Nanomedicine, Journal Year: 2023, Volume and Issue: Volume 18, P. 5031 - 5054
Published: Sept. 1, 2023
Introduction: The lack of osteoinductive, angiogenic and antimicrobial properties hydroxyapatite coatings (HA) on titanium surfaces severely limits their use in orthopedic dental implants. Therefore, we doped SiO 2 , Gd O 3 CeO nanoparticles into HA to fabricate a HASiGdCe coating with combination decent antibacterial, osteogenic by the plasma spraying technique. Methods: was analyzed SEM (EDS), surface roughness tests, contact angle XRD, FTIR spectroscopy, tensile tests electrochemical dynamic polarization tests. Methicillin-resistant Staphylococcus aureus (MRSA) Pseudomonas aeruginosa (PAO-1) were used as representative bacteria verify antibacterial coating. We evaluated cytocompatibility vitro osteoinductivity investigating its effect cell viability differentiation MC3T3-E1 cells. assessed activity migration assay, tube formation RT‒PCR analysis genes HUVECs. Finally, infected animal femur models investigate biosafety, osteointegration vivo. Results: Through various characterization experiments, demonstrated that has suitable microscopic morphology, physical phase characteristics, bonding strength bioactivity meet criteria for can release 3+ Ce 4+ showing strong against MRSA PAO-1. been shown have superior compared cellular experiments. Animal implantation experiments also excellent Conclusion: confers implants, which effectively enhance implant osseointegration prevent bacterial infections, it accordingly promising applications treatment bone defects related sciences. Graphical Abstract: Keywords: coatings, osseointegration,
Language: Английский
Citations
3
Applied Sciences, Journal Year: 2024, Volume and Issue: 14(8), P. 3234 - 3234
Published: April 11, 2024
This paper presents the study results of formation features composite hydrogel/polyamide membranes obtained by modification hydrogel films based on 2-hydroxyethylmethacrylate (HEMA) and polyvinylpyrrolidone (PVP) copolymers. The process two-layer was carried out in two stages: obtaining membrane substrates followed their with an ultra-thin layer a mixture polyamide (PA) PVP. main task work to investigate possibility forming modifying PA/PVP coating surface obtain required strength osmotic permeability them. For membranes, PVP MM = 12 × 103 g/mol 360 were used. Additional use solution contributes its penetration into substrate. Together reinforcing layer, this ensures obtainment increased strength, directional regulation diffusion permeability. It found that factors affecting nature interaction between layers films, as well physico-mechanical sorption–diffusion properties, are HEMA:PVP ratio original polymer–monomer composition (PMC), formulation duration molecular weight PMC solution. water content salt coefficients, highest case using high-molecular (MMPVP g/mol) low-molecular during synthesis substrate PA-6/PVP for layer.
Language: Английский
Citations
0
Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: 170, P. 113504 - 113504
Published: Nov. 6, 2024
Language: Английский
Citations
0
Published: Jan. 1, 2024
Language: Английский
Citations
0