The Role of Injectable Platelet-Rich Fibrin in Orthopedics: Where Do We Stand?

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(4), P. 239 - 239

Published: March 29, 2025

Injectable Platelet-Rich Fibrin (i-PRF) has emerged as a promising tool in regenerative medicine, particularly orthopedics, due to its unique biological properties and ease of preparation. i-PRF is an autologous platelet concentrate derived through simple, anticoagulant-free centrifugation process, resulting liquid matrix enriched with fibrin, leukocytes, growth factors. These components promote tissue regeneration, angiogenesis, anti-inflammatory responses, making suitable for bone cartilage repair well drug delivery systems. This review discusses the history, mechanisms, clinical applications highlighting potential advantages over traditional platelet-rich plasma (PRP). Furthermore, we address challenges limitations i-PRF, including stability, release control, bioactive interactions, underscoring need further research optimize therapeutic efficacy.

Language: Английский

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Self‐Healing Hydrogels: Mechanisms and Biomedical Applications

MedComm, Journal Year: 2025, Volume and Issue: 6(5)

Published: April 24, 2025

ABSTRACT Hydrogels have emerged as dependable candidates for tissue repair because of their exceptional biocompatibility and tunable mechanical properties. However, conventional hydrogels are vulnerable to damage owing stress environmental factors that compromise structural integrity reduce lifespan. In contrast, self‐healing with inherent ability restore structure function autonomously offer prolonged efficacy enhanced appeal. These can be engineered into innovative forms including stimulus‐responsive, self‐degradable, injectable, drug‐loaded variants, thereby enhancing applicability in wound healing, drug delivery, engineering. This review summarizes the categories mechanisms hydrogels, along biomedical applications, repair, biosensing. Tissue includes bone‐related nerve cardiac repair. Additionally, we explored challenges continue face presented a forward‐looking perspective on development. Consequently, it is anticipated will progressively designed developed applications extend beyond broader range applications.

Language: Английский

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APPLICATION OF BIOREGENERATIVE MATERIALS IN THE TREATMENT OF PERIODONTITIS AND PERIIMPLANTITIS: A SYSTEMATIC REVIEW

The actual problems in dentistry, Journal Year: 2025, Volume and Issue: 21(1), P. 37 - 47

Published: May 1, 2025

Inflammatory diseases of the oral cavity, such as periodontitis and peri-implantitis, remain one leading causes tooth loss decreased quality life for patients. Standard treatment methods focus on eliminating infection inflammation; however, they do not always provide adequate restoration affected tissues. In this context, bioregenerative materials with anti-inflammatory regenerative properties are gaining increasing attention a promising tool in comprehensive therapy. This review is relevant light growing number studies devoted to effectiveness various biomaterials need their systematic analysis. Objective. The aim study systematize existing data materials, determine potential, analyze advantages peri-implantitis. Methodology. was conducted accordance PRISMA guidelines. Literature searches were carried out PubMed, Cochrane Library, Elibrary databases. analysis included randomized controlled trials meta-analyses that met inclusion criteria. Risk Bias used assess studies. Results. Of 404 publications identified, 24 final main platelet-rich fibrin (PRF), hydrogels, bioactive glasses, stem cells. PRF demonstrated high soft tissue healing bone defect regeneration, while hydrogels effective reducing inflammatory processes. Clinical efficacy assessment showed significant improvements probing depth clinical attachment level. Conclusion. Bioregenerative have potential diseases, providing effects. However, further larger sample sizes long-term follow-up necessary widespread implementation.

Language: Английский

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Efficacy of Simvastatin in Inhibiting Bone Resorption and Promoting Healing in Delayed Tooth Avulsion: A Case Series

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

An avulsion is a severe dental injury characterized by the complete displacement of tooth from its socket, often resulting in compromised prognosis. One key factors influencing success reimplantation extraoral dry time, which refers to duration remains outside socket. Prolonged time significantly impairs viability periodontal ligament cells, crucial for successful healing and reattachment. Despite various protocols treatment strategies developed manage avulsed teeth, no single approach addresses all needs effectively, particularly cases delayed reimplantation. Simvastatin, an anti-lipidemic drug, has demonstrated pleiotropic effects that extend beyond cholesterol lowering. These include anti-inflammatory properties, promotion bone regeneration, enhancement cell survival. Such actions suggest simvastatin may have beneficial role improving outcomes following teeth. This case series proposes use as adjunctive teeth along with platelet-rich fibrin hydroxyapatite, situations where delayed. By mitigating inflammation stimulating tissue help counteract damage caused prolonged time. Its potential promote survival enhance processes could improve prognosis reimplantation, even traditional alone would be less effective. Given these promising represent valuable addition protocol extended times. However, further clinical studies trials are necessary validate efficacy establish clear management

Language: Английский

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One-Stage Surgical Management of an Asymptomatic Maxillary Sinus Mucocele with Immediate Lateral Sinus Lift and Simultaneous Implant Placement: A Case Report

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(6), P. 1946 - 1946

Published: March 13, 2025

Background: The relationship between dental implants and sinus mucoceles is an area of growing interest in oral maxillofacial surgery, as therapeutic approaches for these conditions remain controversial. This case report presents a 48-year-old male with no significant medical history who sought care due to recurrent abscesses on the distal abutment five-unit maxillary bridge. Clinical radiographic evaluations, including Cone-Beam Computed Tomography (CBCT), revealed pathologic lesion associated second molar, insufficient alveolar bone height posterior maxilla, radiopaque mass floor. Methods: A one-stage surgical approach was planned, involving molar extraction, cyst removal, floor elevation, simultaneous implant placement. prosthetic restoration completed six months postoperatively. Results: Over 88-month follow-up period, complications were observed, patient reported high satisfaction restoration’s function aesthetics. Conclusions: highlights single-stage strategy’s feasibility long-term success managing asymptomatic while optimizing placement rehabilitation.

Language: Английский

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Complication rates of guided bone regeneration using titanium-reinforced PTFE membranes: a retrospective analysis

Clinical Oral Investigations, Journal Year: 2024, Volume and Issue: 28(11)

Published: Oct. 30, 2024

Language: Английский

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Investigating the Biological Efficacy of Albumin-Enriched Platelet-Rich Fibrin (Alb-PRF): A Study on Cytokine Dynamics and Osteoblast Behavior

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(21), P. 11531 - 11531

Published: Oct. 27, 2024

The development of effective biomaterials for tissue regeneration has led to the exploration blood derivatives such as leucocyte- and platelet-rich fibrin (L-PRF). A novel variant, Albumin-Enriched Platelet-Rich Fibrin (Alb-PRF), been introduced improve structural stability bioactivity, making it a promising candidate bone regeneration. This study aimed evaluate Alb-PRF’s capacity cytokine growth factor release, along with its effects on proliferation, differentiation, mineralization human osteoblasts in vitro. Alb-PRF membranes were analyzed using histological, scanning electron microscopy, fluorescence microscopy techniques. Cytokine release was quantified over seven days, osteoinductive potential evaluated MG-63 osteoblast-like cells. Structural analysis showed biphasic, highly cellularized material that releases lower levels inflammatory cytokines higher concentrations platelet-derived (PDGF) vascular endothelial (VEGF) compared L-PRF. exhibited early alkaline phosphatase activity vitro (p < 0.05) significantly increased OPG/RANKL mRNA ratio 0.05). These results indicate scaffold repair, warranting further vivo clinical assessments confirm suitability applications.

Language: Английский

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Assessment of Tissue Changes Observed with Single-Unit Dental Implants Placed in Conjunction with Platelet-Rich Fibrin: An Evaluative Study

Journal of Microscopy and Ultrastructure, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 16, 2024

Language: Английский

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Platelet-rich fibrin in dentistry

Journal of Applied Biomaterials & Functional Materials, Journal Year: 2024, Volume and Issue: 22

Published: Jan. 1, 2024

Objectives: To review the progress of Platelet Rich Fibrin (PRF) as a biomaterial in dentistry and to highlight its promising application safe biocompatible autologous platelet concentrate. Publications were searched GeenMedical, X-mol, GoogleScholar, PubMed from October 2024 with no language restrictions. The literature was for relevant databases journals on use PRFs up 2024, inclusion criteria included randomized controlled trials, clinical case series, systematic reviews. Conclusion: PRF is second-generation concentrate that sourced oneself, has fewer adverse effects, simple prepare. These materials include growth factors fibrin scaffolds, which are extensively utilized regenerative medicine. By outlining PRF, we found good results can be achieved when used treat these conditions. Clinical significance: widespread, particularly periodontal soft hard tissue regeneration, oral lichen planus, pulpal regeneration. This article reviews background, classification, preparation methods PRFs, along their dental applications. We anticipate further research various derivatives future, will significantly improve utilization applications offer fresh insights diagnosing treating diseases.

Language: Английский

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Advancements in periodontal pathology: A systematic review and meta-analysis of molecular diagnostics, imaging techniques, regenerative therapies, and artificial intelligence

Journal of Oral Medicine Oral Surgery Oral Pathology and Oral Radiology, Journal Year: 2024, Volume and Issue: 10(4), P. 231 - 237

Published: Dec. 15, 2024

: Periodontal diseases, such as gingivitis and periodontitis, are prevalent conditions that adversely affect the supporting structures of teeth. Recent advancements in field periodontal pathology have enhanced understanding disease mechanisms improved diagnostic therapeutic strategies. To provide a comprehensive review current innovations explore emerging technologies future directions could revolutionize care. This synthesizes findings from recent literature on pathology, including molecular diagnostics, imaging techniques, regenerative therapies, application artificial intelligence (AI). A systematic approach was adopted to identify analyze relevant studies, focusing their clinical relevance potential for transforming Key include: 1. Molecular Diagnostics: Improved identification biomarkers early detection progression monitoring. 2. Imaging Techniques: Enhanced visualization using advanced modalities like cone-beam computed tomography (CBCT) optical coherence (OCT). 3. Regenerative Therapies: Breakthroughs tissue engineering, stem cell therapy, biomaterials regeneration. 4. Artificial Intelligence: Integration AI predictive modeling, support, personalized treatment planning. significantly expanded possibilities. Emerging technologies, approaches, hold immense advancements. Continued research integration these critical enhancing care improving patient outcomes.

Language: Английский

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