Multi-Omics Research on Angina Pectoris: A Novel Perspective DOI Creative Commons
Haiyang Chen, Lijun Zhang,

Meiyan Liu

et al.

Aging and Disease, Journal Year: 2024, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2024

Angina pectoris (AP), a clinical syndrome characterized by paroxysmal chest pain, is caused insufficient blood supply to the coronary arteries and sudden temporary myocardial ischemia hypoxia. Long-term AP typically induces other cardiovascular events, including infarction heart failure, posing serious threat patient safety. However, AP's complex pathological mechanisms developmental processes introduce significant challenges in rapid diagnosis accurate treatment of its different subtypes, stable angina (SAP), unstable (UAP), variant (VAP). Omics research has contributed significantly revealing various diseases with development high-throughput sequencing approaches. The application multi-omics approaches effectively interprets systematic information on from perspective genes, RNAs, proteins, metabolites. Integrating introduces novel avenues for identifying biomarkers distinguish subtypes. This study reviewed articles related elaborate progress (including genomics, transcriptomics, proteomics, metabolomics), summarized their applications screening employed discriminate multiple delineated integration methods Finally, we discussed advantages disadvantages applying single-omics approach distinguishing diverse Our review demonstrated that technologies preferable quick precise three types, namely SAP, UAP, VAP.

Language: Английский

A Nomogram Based on Ocular Hemodynamics for Predicting Ischemic Stroke DOI Creative Commons
Zhuohua Zhou,

Xue-ru Cheng,

Jia-xin Guan

et al.

American Journal of Ophthalmology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Ischemic stroke is a cerebrovascular disease with high mortality and disability. Due to similar physiological characteristics, ocular vascular characteristics are important indicators for monitoring diseases. This study aimed develop nomogram prediction model ischemic based on hemodynamic characteristics. Retrospective clinical cohort study. A total of 337 patients were included in this randomly divided into 253 training 102 validation cohorts. The general data collected, the parameters ophthalmic artery, central retinal artery posterior ciliary detected by ultrasound. diameter was extracted from color fundus image, relevant laboratory indexes collected. Logistic regression analysis used determine risk factors stroke. constructed identified factors, accuracy applicability analyzed using receiver operating curve (ROC), Hosmer-Lemeshow test, decision (DCA). Independent including hypertension (OR 2.17, 95% confidence interval [CI] 1.16 4.08; P = 0.016), hyperlipidemia 2.21, CI 1.18 4.14; 0.013), resistance index 5.98, 3.27 10.93; < 0.001) multivariate analysis. area under ROC 0.790 (95% 0.733 0.847) that 0.773 0.679 0.866), revealing consistent ability predict mean absolute error train cohorts 0.020 0.013, respectively. In addition, DCA showed good benefit. combining traditional has preferable predictive performance suggests combined hemodynamics can effectively promote early diagnosis intervention

Language: Английский

Citations

0
Crosstalk between lipid metabolism and macrophages in atherosclerosis: therapeutic potential of natural products DOI Creative Commons

Taoming Qian,

Dong Guo, Lu Sun

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 12

Published: March 3, 2025

Atherosclerosis is a highly prevalent cardiovascular condition that affects individuals worldwide. Despite ongoing research into its treatment and prevention, atherosclerotic disease continues to exhibit high morbidity mortality rates. The accumulation of low-density lipoprotein cholesterol considered major contributor the development atherosclerosis, with abnormalities in lipid metabolism playing significant role pathogenesis. Lipid macrophage function are intricately interconnected, being influenced by inflammatory responses, while activity regulated alterations metabolism. interaction between these two processes plays critical progression atherosclerosis. Natural products have shown considerable promise treating variety diseases, including Moreover, modulation crosstalk represents key mechanism through which natural may exert their effects. This aims provide new insights current state on regulating this pathway interplay macrophages context offering potential directions for future.

Language: Английский

Citations

0
Impact of insulin resistance and microvascular ischemia on myocardial energy metabolism and cardiovascular function: pathophysiology and therapeutic approaches DOI Creative Commons

Ariana Ramirez,

Elizabeth R. Doman, Katherine Sanchez

et al.

Cardiovascular Endocrinology & Metabolism, Journal Year: 2025, Volume and Issue: 14(2)

Published: April 16, 2025

Insulin resistance (IR) and microvascular ischemia together result in cardiovascular dysfunction by impairing the heart’s energy balance. IR cardiomyocytes disrupts glucose metabolism, leading to deficits that can drive cardiac hypertrophy heart failure. Microvascular exacerbates these effects limiting oxygen nutrient delivery, intensifying oxidative stress, mitochondrial dysfunction, cell death. also reduces effectiveness of vasodilators like nitroglycerin sodium nitroprusside, exacerbating endothelial thus delivery during ischemia. This combination heightens risk left ventricular Understanding interactions is critical for developing targeted therapies improve outcomes patients with ischemic disease. study examines relationship between IR, ischemia, myocardial a focus on clinical management therapeutic strategies.

Language: Английский

Citations

0
Longitudinal mitochondrial bioenergetic signatures of blood monocytes and lymphocytes improve during treatment of drug-susceptible pulmonary tuberculosis patients Monocyte/lymphocyte bioenergetic signatures post-TB treatment DOI Creative Commons
Bridgette M. Cumming,

Kelvin W. Addicott,

Fernanda Maruri

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 13, 2024

The impact of human pulmonary tuberculosis (TB) on the bioenergetic metabolism circulating immune cells remains elusive, as does resolution these effects with TB treatment. In this study, rates oxidative phosphorylation (OXPHOS) and glycolysis in lymphocytes monocytes patients drug-susceptible at diagnosis, 2 months, 6 months during treatment, 12 after diagnosis were investigated using extracellular flux analysis. At parameters both blood severely impaired comparison to non-TB non-HIV-infected controls. However, most not affected by HIV status or glycemic index. Treatment restored % spare respiratory capacity (%SRC) that observed non-HIV infected controls months. also improved maximal respiration %SRC patients. Notably, differential correlation clinical from baseline month was consistent metabolic health inflammation following successful Network analysis serum cytokine levels indicated a highly coordinated response 6. These findings underscore importance combating TB, supporting need for further investigation immunometabolism associated infection novel therapeutic approaches aimed bolstering cellular energetics enhance responses expedite recovery

Language: Английский

Citations

1
Multi-Omics Research on Angina Pectoris: A Novel Perspective DOI Creative Commons
Haiyang Chen, Lijun Zhang,

Meiyan Liu

et al.

Aging and Disease, Journal Year: 2024, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2024

Angina pectoris (AP), a clinical syndrome characterized by paroxysmal chest pain, is caused insufficient blood supply to the coronary arteries and sudden temporary myocardial ischemia hypoxia. Long-term AP typically induces other cardiovascular events, including infarction heart failure, posing serious threat patient safety. However, AP's complex pathological mechanisms developmental processes introduce significant challenges in rapid diagnosis accurate treatment of its different subtypes, stable angina (SAP), unstable (UAP), variant (VAP). Omics research has contributed significantly revealing various diseases with development high-throughput sequencing approaches. The application multi-omics approaches effectively interprets systematic information on from perspective genes, RNAs, proteins, metabolites. Integrating introduces novel avenues for identifying biomarkers distinguish subtypes. This study reviewed articles related elaborate progress (including genomics, transcriptomics, proteomics, metabolomics), summarized their applications screening employed discriminate multiple delineated integration methods Finally, we discussed advantages disadvantages applying single-omics approach distinguishing diverse Our review demonstrated that technologies preferable quick precise three types, namely SAP, UAP, VAP.

Language: Английский

Citations

0