Therapeutic detoxification of quercetin for aflatoxin B1-related toxicity: Roles of oxidative stress, inflammation, and metabolic enzymes

Environmental Pollution, Journal Year: 2024, Volume and Issue: 345, P. 123474 - 123474

Published: Feb. 1, 2024

Language: Английский

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Quercetin-functionalized nanomaterials: Innovative therapeutic avenues for Alzheimer's disease management

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102665 - 102665

Published: Jan. 1, 2025

Language: Английский

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SIRT1 Regulates Fumonisin B1-Induced LMH Cell PANoptosis and Antagonism of Lycopene

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Mycotoxin contamination is a universal agricultural problem and critical health issue. Fumonisin B1 (FB1) one of the most toxic extensive fumonisins that exist in various agro-products foods. Lycopene (LYC), as natural carotenoid, becoming increasingly favored owing to its oxidation resistance. Here, we aim explore mechanism FB1-induced hepatotoxicity antagonism LYC. In this study, our findings indicated FB1 induced mitochondrial structure damage loss function chicken hepatocytes. Furthermore, upregulated expression PANoptosis-related signal molecules. also reduced levels SIRT1 Ac-FOXO1 protein expression, which then inhibited mitophagy. However, LYC relieved these alterations. Most importantly, knockdown protective effects PANoptosis. Our study provides evidence for role mycotoxin-induced hepatocyte injury points potential target liver protection.

Language: Английский

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Mitochondria in cutaneous health, disease, ageing and rejuvenation—the 3PM-guided mitochondria-centric dermatology

The EPMA Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Association of both intrinsic and extrinsic risk factors leading to accelerated skin ageing is reflected in excessive ROS production ir/reversible mitochondrial injury burnout, as abundantly demonstrated by accumulating research data. Due the critical role stress pathophysiology disorders, maintained (primary care) restored (secondary health, rejuvenation homoeostasis are considered most effective holistic approach advance dermatological treatments based on systemic health-supportive stimulating measures. Per evidence, an anti-ageing protection, wound healing scarring quality - all strongly depend sustainable functionality well-balanced homoeostasis. The latter can be objectively measured and, if necessary, a manner pre- rehabilitation algorithms tailored individualised patient profiles. entire spectrum corresponding innovations area includes natural rejuvenation, aesthetic reconstructive medicine, protection targeted disorders. Contextually, mitochondria-centric dermatology instrumental for advanced 3PM-guided which makes good use predictive multi-level diagnostics against health-to-disease transition progression relevant Cost-effective new treatment avenues focused health physiologic proposed article including in-depth analysis cases exemplified care with detailed mechanisms expert recommendations presented.

Language: Английский

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Novel Role of the SIRT1 in Endocrine and Metabolic Diseases

International Journal of Biological Sciences, Journal Year: 2022, Volume and Issue: 19(2), P. 484 - 501

Published: Dec. 19, 2022

Silent information regulator 1 (SIRT1), a highly conserved NAD+-dependent deacetylase, is cellular that has received extensive attention in recent years and regarded as sensor of energy metabolism. The accumulated evidence suggests SIRT1 involved the development endocrine metabolic diseases. In variety organisms, regulates gene expression through deacetylation histone, transcription factors, lysine residues other modified proteins including several signal thereby enhancing therapeutic effects These evidences indicate targeting promising applications treatment This review focuses on role First, we describe background structure SIRT1. Then, outline diseases such hyperuricemia, diabetes, hypertension, hyperlipidemia, osteoporosis, polycystic ovarian syndrome. Subsequently, agonists inhibitors above are summarized future research directions proposed. Overall, presents here may highlight potential biomarker target for

Language: Английский

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Quercetin inhibits DNA damage responses to induce apoptosis via SIRT5/PI3K/AKT pathway in non-small cell lung cancer

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 165, P. 115071 - 115071

Published: June 28, 2023

SIRT5 is a mitochondrial NAD+ -dependent lysine deacylase. Downregulation of has been linked to several primary cancers and DNA damage. In clinical therapy for non-small cell lung cancer (NSCLC), the Feiyiliu Mixture (FYLM) an experience effective Chinese herb prescription. And we found that quercetin important ingredient in FYLM. However, whether regulates damage repair (DDR) induces apoptosis through NSCLC remains unknown. The present study revealed directly binds inhibits phosphorylation PI3K/AKT interaction between PI3K, thus inhibiting process homologous recombination (HR) non-homologous end-joining (NHEJ) NSCLC, which raise mitotic catastrophe apoptosis. Our provided novel mechanism action treatment NSCLC.

Language: Английский

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Quercetin alleviates lipopolysaccharide‑induced acute lung injury by inhibiting ferroptosis via the Sirt1/Nrf2/Gpx4 pathway

International Journal of Molecular Medicine, Journal Year: 2023, Volume and Issue: 52(6)

Published: Oct. 20, 2023

Acute lung injury (ALI) causes high morbidity and mortality rates in critically ill patients, there are currently no effective therapeutic drugs. Ferroptosis is a newly discovered mode of regulated cell death that contributes to the progression ALI. Quercetin possesses anti‑inflammatory antioxidant properties. However, whether quercetin can protect against lipopolysaccharide (LPS)‑induced ALI by inhibiting ferroptosis its underlying mechanisms remains unclear. The present study evaluated protective effects molecular LPS‑induced establishing an mouse model alveolar epithelial via treatment mice or cells with LPS. Mouse was assessed evaluating histological score, bronchoalveolar lavage fluid count inflammatory cytokine levels; Cell counting kit‑8, lactate dehydrogenase EDU assays; detecting changes levels malondialdehyde, glutathione, iron, glutathione peroxidase 4 (Gpx4) 4‑hydroxynonenal in vivo vitro. indicated effectively ameliorated reducing histopathological changes, proinflammatory release reactive oxygen species generation ferroptosis. significantly decreased improved proliferative ability LPS‑treated cells. Additionally, it demonstrated markedly enhanced barrier, as evidenced upregulation tight junction protein expression both vitro. Mechanistically, activated sirtuin 1 (Sirt1)/nuclear factor erythroid 2‑related 2 (Nrf2)/Gpx4 signaling pathway, targeted inhibition vitro knockdown Sirt1 reduced anti‑ferroptotic functions quercetin. In conclusion, results exerts activation Sirt1/Nrf2/Gpx4 pathway.

Language: Английский

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Advance in the pharmacological effects of quercetin in modulating oxidative stress and inflammation related disorders

Phytotherapy Research, Journal Year: 2023, Volume and Issue: 37(11), P. 4999 - 5016

Published: July 25, 2023

Abstract Numerous pharmacological effects of quercetin have been illustrated, including antiinflammation, antioxidation, and anticancer properties. In recent years, the antioxidant activity has extensively reported, in particular, its impacts on glutathione, enzyme activity, signaling transduction pathways, reactive oxygen species (ROS). Quercetin also demonstrated to exert a striking antiinflammatory effect mainly by inhibiting production cytokines, reducing expression cyclooxygenase lipoxygenase, preserving integrity mast cells. By regulating oxidative stress inflammation, which are regarded as two critical processes involved defense regular physiological operation biological systems, validated be effective treating variety disorders. Symptoms these reactions linked degenerative metabolic disorders, syndrome, cardiovascular, neurodegeneration, cancer, nonalcoholic fatty liver disease. Despite that evidence demonstrates antioxidants employed prevent excessive inflammatory processes, there still concerns regarding expense, accessibility, side agents. Notably, natural products, especially those derived from plants, widely accessible, affordable, generally safe. this review, abilities active ingredient application stress‐related disorders outlined detail.

Language: Английский

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SIRT1/FOXO3-mediated autophagy signaling involved in manganese-induced neuroinflammation in microglia

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 256, P. 114872 - 114872

Published: April 5, 2023

Manganese (Mn), as one of the environmental risk factors for Parkinson's disease (PD), has been widely studied. Though autophagy dysfunction and neuroinflammation mainly are responsible causative issue Mn neurotoxicity, molecular mechanism parkinsonism caused by not explored clearly. The results in vivo vitro experiments showed that overexposure to impairment dysfunction, accompanied increase IL-1β, IL-6, TNF-α mRNA expression, nerve cell apoptosis, microglia activation, NF-κB poor neurobehavior performance. This is due Mn-induced downregulation SIRT1. Upregulation SIRT1 could alleviate neuroinflammation, yet these beneficial effects were abolished following 3-MA administration. Furthermore, we found interfered with acetylation FOXO3 BV2 cells, leading a decrease nuclear translocation FOXO3, its binding LC3B promoter transcription activity. be antagonized upregulation Finally, it proved SIRT1/FOXO3-LC3B signaling involves impairment.

Language: Английский

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The potential role of plant secondary metabolites on antifungal and immunomodulatory effect

Applied Microbiology and Biotechnology, Journal Year: 2023, Volume and Issue: 107(14), P. 4471 - 4492

Published: June 5, 2023

Language: Английский

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