Role of Antioxidant Therapy in Respiratory Disease Management DOI Creative Commons
Baby Bhattacharya,

Naina Devi,

Sanshita

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: unknown, P. 219 - 255

Published: Nov. 17, 2024

Respiratory diseases exert a substantial impact and an indelible imprint on the quality of life significant portion global populace. Diseases such as Asthma, Chronic obstructive pulmonary disease, Idiopathic fibrosis, etc., have major association with reactive oxygen species oxidative stress in their underlying fundamental pathogenesis. Antioxidants are substances that elucidate action by slowing down or blocking oxidation other chemicals been found to protective for management oxidant stress. This book chapter aims excavate into domain antioxidants how they useful mitigation these respiratory diseases. A plethora antioxidant compounds, along mechanistic role classification also discussed comprehensively. gives insight various drug delivery systems employed help reach site action. Lastly, future perspectives pertaining holistically explored lay out possibilities amalgamation innovative novel concepts personalized medicine, 3D printing improve therapeutic efficacy antioxidants.

Language: Английский

Latest advances in hepatocellular carcinoma management and prevention through advanced technologies DOI Creative Commons

Tamer A. Addissouky,

Ibrahim El Tantawy El Sayed, Majeed M. A. Ali

et al.

Egyptian Liver Journal, Journal Year: 2024, Volume and Issue: 14(1)

Published: Jan. 2, 2024

Abstract Background Hepatocellular carcinoma (HCC) is a common type of liver cancer, with high mortality rate. cancer that can be effectively managed through early detection and accurate diagnosis, followed by personalized treatment plan may include surgical resection, transplantation, minimally-invasive techniques, immunotherapy, or targeted therapy depending on the stage severity cancer. Main body abstract This paper discusses recent advances in detection, management, prevention HCC. The use newer imaging such as Magnetic resonance (MRI) contrast-enhanced ultrasound, along image segmentation technology deep learning models, have greatly enhanced accuracy HCC diagnosis. Minimally-invasive thermal ablation radiofrequency ablation, allowed for more precise destruction tumors, while Nanoparticles, immunotherapy shown promise management advanced Artificial intelligence (AI) machine has revolutionized research, aiding identification high-risk patients predicting outcomes. Lifestyle modifications, weight alcohol avoidance, hepatitis B vaccinations, play critical role preventing development. Short conclusion Recent improving patient therapy, AI research lifestyle modifications prevention. However, further required to fully understand potential benefits nanoparticles, traditional Chinese medicine herbal medicines treatment. Graphical

Language: Английский

Citations

35
Altered glycosylation in cancer: molecular functions and therapeutic potential DOI Creative Commons
Xuemeng Xu, Qiu Peng,

Xianjie Jiang

et al.

Cancer Communications, Journal Year: 2024, Volume and Issue: 44(11), P. 1316 - 1336

Published: Sept. 21, 2024

Abstract Glycosylation, a key mode of protein modification in living organisms, is critical regulating various biological functions by influencing folding, transportation, and localization. Changes glycosylation patterns are significant feature cancer, associated with range pathological activities cancer‐related processes, serve as biomarkers providing new targets for cancer diagnosis treatment. Glycoproteins like human epidermal growth factor receptor 2 (HER2) breast alpha‐fetoprotein (AFP) liver carcinoembryonic antigen (CEA) colon prostate‐specific (PSA) prostate all tumor approved clinical use. Here, we introduce the diversity structures newly discovered substrate—glycosylated RNA (glycoRNA). This article focuses primarily on metastasis, immune evasion, metabolic reprogramming, aberrant ferroptosis responses, cellular senescence to illustrate role cancer. Additionally, summarize applications diagnostics, treatment, multidrug resistance. We envision promising future glycosylation.

Language: Английский

Citations

10
Advancing mass spectrometry–based glycoproteomic software tools for comprehensive site-specific glycoproteome analysis DOI
Weiqian Cao

Current Opinion in Chemical Biology, Journal Year: 2024, Volume and Issue: 80, P. 102442 - 102442

Published: March 8, 2024

Language: Английский

Citations

7
Metabolism-driven glycosylation represents therapeutic opportunities in interstitial lung diseases DOI Creative Commons

Katarzyna Drzewicka,

Zbigniew Zasłona

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: March 14, 2024

Metabolic changes are coupled with alteration in protein glycosylation. In this review, we will focus on macrophages that pivotal the pathogenesis of pulmonary fibrosis and sarcoidosis thanks to their adaptable metabolism an attractive therapeutic target. Examples presented review demonstrate glycosylation regulates metabolism-driven immune responses macrophages, implications for fibrotic processes granuloma formation. Targeting proteins regulate glycosylation, such as fucosyltransferases, neuraminidase 1 chitinase could effectively block immunometabolic driving inflammation fibrosis, providing novel avenues interventions.

Language: Английский

Citations

7
Integrative Quantitative Analysis of Platelet Proteome and Site-Specific Glycoproteome Reveals Diagnostic Potential of Platelet Glycoproteins for Liver Cancer DOI

Xiaofeng Xie,

Jian‐Feng Xiang, Huanhuan Zhao

et al.

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

The role of peripheral blood platelets as indicators cancer progression is increasingly recognized, and the significance abnormal glycosylation in platelet function related disorders gaining attention. However, potential a source protein site-specific for diagnosis remains underexplored. In this study, we proposed general pipeline that integrates quantitative proteomics with glycoproteomics, allowing an in-depth investigation glycoproteome. With pipeline, generated data set comprising 3,466 proteins qualitative information, 3,199 3,419 glycans information 3,377 from hepatocellular carcinoma (HCC) patients, metastatic liver (mLC) healthy controls. integrated analysis revealed significant changes N-glycosylation patients. Further systems biology lectin pull-down-coupled ELISA assays independent clinical samples confirmed two N-glycoproteins specific glycan types, complement C3 (C3) oligomannose modification integrin β-3 (ITGB3) sialylation, biomarkers distinguishing patients individuals, without differentiating between HCC mLC patient group. These findings highlight biomarkers.

Language: Английский

Citations

0
Targeting Non-Eosinophilic Immunological Pathways in COPD and AECOPD: Current Insights and Therapeutic Strategies DOI Creative Commons

Dur E Maknoon Razia,

Chencheng Gao,

Chao Wang

et al.

International Journal of COPD, Journal Year: 2025, Volume and Issue: Volume 20, P. 511 - 532

Published: March 1, 2025

COPD is a multifactorial illness characterized by long-term restriction of airflow and an inflammatory reaction in the lungs. The associated emphysema leads to breakdown alveolar proteins abnormal expansion lung air spaces. Chronic bronchitis caused same disease can result increased deposition structural proteins, narrowing airways, excessive mucus secretion leading acute exacerbation (AECOPD). most commonly prescribed medications for it, such as glucocorticoids bronchodilators, provide important therapeutic benefits, but they also have negative side effects, including immunosuppression infection. Therefore, it necessary develop treatment that specifically target immune system molecular components. This review focuses on non-eosinophilic aspects immunological modulation management. Since, existing literature extensively covers eosinophilic inflammation, this aims fill gap examining alternative pathways their implications. findings suggest targeting specific responses may enhance efficacy while minimizing adverse effects with traditional therapies. In summary, emphasizes importance advancing research into mechanisms COPD, prescribing development novel therapies more effectively manage disease.

Language: Английский

Citations

0
The Exploitation of the Glycosylation Pattern in Asthma: How We Alter Ancestral Pathways to Develop New Treatments DOI Creative Commons
Angelika Muchowicz, Agnieszka Bartoszewicz, Zbigniew Zasłona

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(5), P. 513 - 513

Published: April 24, 2024

Asthma has reached epidemic levels, yet progress in developing specific therapies is slow. One of the main reasons for this fact that asthma an umbrella term various distinct subsets. Due to its high heterogeneity, it difficult establish biomarkers each subset and propose endotype-specific treatments. This review focuses on protein glycosylation as a process activated ways utilize develop novel We discuss known relevant glycoproteins whose functions control disease development. The key role processes integral asthma, such inflammation, tissue remodeling, repair, justifies our interest research field glycobiology. Altering states proteins contributing can change pathological we previously failed inhibit. Special emphasis placed chitotriosidase 1 (CHIT1), enzyme capable modifying LacNAc- LacdiNAc-containing glycans. expression activity CHIT1 are induced human diseased lungs, been demonstrated by both genetic pharmacological approaches. studying pattern enzymes involved help patient stratification personalized treatment.

Language: Английский

Citations

2
Bioinformatics Analysis and Experimental Validation to Identify Key Glycosylation-Related Genes in Asthma DOI Creative Commons
Yue Li,

Ruhao Wu,

Xiaoying Tian

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 9469 - 9484

Published: Nov. 1, 2024

Asthma is a chronic inflammatory disease influenced by complex genetic and environmental factors. Despite extensive research, the intricate pathophysiology of asthma remains incompletely understood. Furthermore, effects glycosylation on remain unclear. Considering that glycosylation-related genes have not been reported in patients with asthma, we aimed this study to identify key involved their potential as therapeutic targets.

Language: Английский

Citations

0
Role of Antioxidant Therapy in Respiratory Disease Management DOI Creative Commons
Baby Bhattacharya,

Naina Devi,

Sanshita

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: unknown, P. 219 - 255

Published: Nov. 17, 2024

Respiratory diseases exert a substantial impact and an indelible imprint on the quality of life significant portion global populace. Diseases such as Asthma, Chronic obstructive pulmonary disease, Idiopathic fibrosis, etc., have major association with reactive oxygen species oxidative stress in their underlying fundamental pathogenesis. Antioxidants are substances that elucidate action by slowing down or blocking oxidation other chemicals been found to protective for management oxidant stress. This book chapter aims excavate into domain antioxidants how they useful mitigation these respiratory diseases. A plethora antioxidant compounds, along mechanistic role classification also discussed comprehensively. gives insight various drug delivery systems employed help reach site action. Lastly, future perspectives pertaining holistically explored lay out possibilities amalgamation innovative novel concepts personalized medicine, 3D printing improve therapeutic efficacy antioxidants.

Language: Английский

Citations

0