Neuroscience, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 1, 2024
Language: Английский
Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 13(6)
Published: Nov. 22, 2023
Abstract Esophageal cancer (EC) treatment via anti‐angiogenic therapy faces challenges due to non‐cytotoxicity and non‐specific biodistribution of the agents. Hence, quest for a synergistic modality targeted delivery approach effectively address EC has become imperative. In this study, an acid‐responsive release nanosystem (Bev‐IR820@Fe III TA) that involves conjugation bevacizumab, monoclonal antibody, with TA Fe 3+ form metal‐phenolic network, followed by loading near‐infrared photothermal agent (IR820) achieve combinational therapy, is designed. The construction Bev‐IR820@Fe can be realized through facile self‐assembly process. exhibits tumor‐targeting capabilities therapeutic effects, encompassing (PTT), ferroptosis (FT). remarkable proficiency in delivering drugs tissue its pH‐responsive properties. Consequently, bevacizumab exerts effects obstructing tumor angiogenesis, thereby impeding growth. Meanwhile, PTT facilitates localized thermal ablation at site, directly eradicating cells. FT synergistically collaborates PTT, giving rise formation reactive oxygen species (ROS) storm, subsequently culminating demise summary, amalgamated carries substantial promise progression showcases auspicious prospects future treatment.
Language: Английский
Citations
10
Current Research in Biotechnology, Journal Year: 2024, Volume and Issue: 7, P. 100203 - 100203
Published: Jan. 1, 2024
Fucoxanthin (FX) is a carotenoid of marine origin primarily distributed in brown seaweeds and has garnered interest for its antioxidative, anti-inflammatory, anticancer properties. Despite potential, comprehensive understanding effects mechanisms action remains elusive. The aim this review to present novel insights into the FX, shedding light on previously unexplored molecular synergistic potential with established chemotherapeutic agents. A search was conducted employing databases like PubMed/MedLine, Scopus, Web Science aggregate relevant pharmacological experimental studies. results studies showed that FX exhibits activity against various cancer types, including breast, colorectal, lung cancer, through multiple pathways: cell cycle arrest, apoptosis induction, inhibition angiogenesis. Additionally, potentiates existing agents, making it candidate combination therapies. evidence suggests possesses considerable properties, acting diverse mechanisms; heterogeneity study designs limited number clinical trials make hard conclude. Further in-depth studies, particularly randomized controlled trials, are essential validating FX's efficacy paving way integration standard treatment regimens; additional research needed explore pharmacokinetics, safety profile, chemotherapeutics.
Language: Английский
Citations
3
Nanoscale Advances, Journal Year: 2024, Volume and Issue: 6(12), P. 3135 - 3145
Published: Jan. 1, 2024
The interplay between vascularization and macrophage-induced immune suppression plays a crucial role in melanoma treatment. In this study, we propose novel combination approach to combat by simultaneously inhibiting tumor enhancing macrophage-mediated anti-tumor responses. We investigate the potential of combining combretastatin A4 (CA4), vascular-disrupting agent, with poly(I:C) (PIC), an immunostimulatory adjuvant. This effectively suppresses cell proliferation, disrupts vascularization, promotes macrophage polarization towards M1 phenotype for suppression. To facilitate efficient co-delivery CA4 PIC enhanced anti-angiogenic immunotherapy, develop injectable metal-organic framework hydrogel using Zeolitic Imidazolate Framework-8 (ZIF-8) hyaluronic acid (HA) (ZIF-8/HA). Our findings demonstrate that ZIF-8 enables loading enhances stability against RNAase degradation
Language: Английский
Citations
3
Food Science & Nutrition, Journal Year: 2024, Volume and Issue: 12(10), P. 7088 - 7107
Published: Aug. 29, 2024
Abstract Cancer remains a critical global health challenge, with limited progress in reducing mortality despite advancements diagnosis and treatment. The growing resistance of tumors to existing chemotherapy exacerbates this burden. In response, the search for new anticancer compounds from plants has intensified, given their historical success yielding effective treatments. This review focuses on α‐solanine, glycoalkaloid primarily derived potato tubers nightshade family plants, recognized its diverse biological activities, including anti‐allergic, antipyretic, anti‐inflammatory, anti‐diabetic, antibiotic properties. Recently, α‐solanine gained attention as potential agent. Utilizing resources like PubMed/MedLine, ScienceDirect, Web Science, Scopus, American Chemical Society, Google Scholar, Springer Link, Wiley, various commercial websites, consolidates two decades research α‐solanine's effects mechanisms against nine different cancers, highlighting role modulating signaling pathways. It also discusses lead compound cancer therapy. abundant availability peel, often discarded waste or sold cheaply, is suggested sustainable source large‐scale extraction. study concludes that holds promise standalone adjunctive However, further necessary optimize mitigate toxicity through strategies.
Language: Английский
Citations
3
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2763 - 2763
Published: March 19, 2025
Glioblastomas (GBMs), among the most aggressive and resilient brain tumors, characteristically exhibit high angiogenic potential, leading to formation of a dense yet aberrant vasculature, both morphologically functionally. With these premises, numerous expectations were initially placed on anti-angiogenic therapies, soon dashed by their limited efficacy in concretely improving patient outcomes. Neovascularization GBM emerged as complex, dynamic, heterogeneous process, hard manage with classical standard care. Growing evidence has revealed existence non-canonical strategies angiogenesis, variously exploited meet its ever-increasing metabolic demand differently involved tumor progression, recurrence, escape from treatments. In this review, we provide an accurate description each neovascularization mode encountered tumors date, highlighting molecular players signaling cascades primarily involved. We also detail key architectural functional aspects characteristic vascular compartment because intricate crosstalk between different networks. Additionally, explore repertoire emerging therapies against that are currently under study, concluding question: faced such challenging scenario, could combined tailored patient’s genetic signatures, represent effective game changer?
Language: Английский
Citations
0
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: April 23, 2024
Keywords: vascular endothelial growth factor A, bevacizumab, antiangiogenesis, direct antitumor activity, tumor cells
Language: Английский
Citations
3
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: April 17, 2024
Introduction: Vasculogenic mimicry (VM) represents a novel form of tumor angiogenesis that is associated with invasiveness and drug resistance. However, the VM landscape across cancer types remains poorly understood. In this study, we elucidate characterizations cancers based on multi-omics data provide potential targeted therapeutic strategies. Methods: Multi-omics from The Cancer Genome Atlas was used to conduct comprehensive analyses characteristics related genes (VRGs) types. Pan-cancer vasculogenic score established depiction correlation between phenotypes conducted explore regulatory mechanisms VM. We further systematically examined relationship both immunity microenvironment (TME). addition, cell communication analysis single-cell transcriptome investigate interactions cells TME. Finally, transcriptional response Genomics Drug Sensitivity in database were utilized identify targets drugs. impact immunotherapy also clarified. Results: Our study revealed VRGs dysregulated regulated by multiple mechanisms. Then, level found be heterogeneous among different tumors correlated invasiveness, metastatic potential, malignancy, prognosis. strongly epithelial-mesenchymal transition (EMT). Further cancer-associated fibroblasts can promote EMT formation. Furthermore, immune-suppressive state characterized high levels as an indicator predict effect immunotherapy. seven drugs targeting identified. Conclusion: conclusion, key various types, underscoring pivotal role CAFs immunosuppressive clues for research provides initial overview reference point future VM, opening up new avenues intervention.
Language: Английский
Citations
2
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(23), P. 17065 - 17065
Published: Dec. 2, 2023
Angiogenesis significantly influences the carcinogenesis of thymic epithelial tumors (TET). Both thymomas and carcinoma (TC) overexpress VEGF-A VEGFR-1 -2. This review aims to provide an appraisal use anti-angiogenics in treatment TET. The literature research identified 16 studies that were deemed eligible for further analysis. Seven assessed clinical efficacy sunitinib five apatinib and/or anlotinib. multicenter Japanese phase II REMORA trial investigated lenvatinib, which is a multi-targeted inhibitor VEGFR, FGFR, RET, c-Kit, other kinases. objective response rate was 38% (25.6-52%), highest documented TET progressed after first-line chemotherapy. Anti-angiogenic agents may be useful TET, are not amenable curative treatment. Their toxicity profile seems acceptable. However, angiogenesis inhibitors do appear have major influence on either or TC, although multikinase some effect TC. current evidence suggests most active agent whereas could proposed as acceptable second-line therapy Further concerning combination immune checkpoint with anti-angiogenic drugs warranted.
Language: Английский
Citations
4
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 25, 2024
Abstract The infected chronic wound area has a unique microenvironment featuring hypoxia, excessive reactive oxygen species (ROS), and inflammatory conditions. Bacteria‐formed biofilms limit the anti‐inflammation efficiency of most therapeutics by hindering their penetration into deep tissues increasing drug resistance. unitary modulation pro‐inflammatory M1 macrophage polarization cannot relieve inflammation immediately. Here, “all in one” folic acid‐modified small organic molecule‐based nanoparticles (2TT‐ m C6B@CeO 2 @FA, PCFs) are developed, which possess dual‐targeting to bacteria macrophages, double photothermal therapy (PTT), enzymatic‐like activities. Based on considerable catalase‐ superoxide dismutase‐like activities, PCFs can efficiently scavenge ROS produce (O ). generated O automatically drive movement as nanomotors further promote rescue hypoxia. scavenging promotes macrophages polarized anti‐inflammatory M2 macrophages. study also identifies that FA‐modified target selectively eliminate through PTT, relieves healing. Transcriptome analysis confirms inhibit expression inflammatory‐related genes while cytokines. In vivo experiments identify benefit neovascularization neonatal tissue generation at sites.
Language: Английский
Citations
1
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10486 - 10486
Published: Sept. 29, 2024
The tumor microenvironment (TME) can be regarded as a complex and dynamic microecosystem generated by the interactions of cells, interstitial extracellular matrix, their products plays an important role in occurrence, progression metastasis tumors. In previous study, we constructed IEO model (prI-, prE-, pOst-metastatic niche) according to chronological sequence TME development. this paper, fill theoretical gap spatial heterogeneity TME, defined MCIB (Metabolic, Circulatory, Immune, microBial microenvironment). divides into four subtypes that interact with each other terms mechanism, corresponding major links metabolic reprogramming, vascular remodeling, immune response, microbial action, providing new way assess TME. combination comprehensively depicts spatiotemporal evolution provide basis for clinical targeted therapy, immunotherapy, comprehensive treatment modalities tumors crosstalk different powerful research paradigm drug-resistance mechanisms biological behavior.
Language: Английский
Citations
1