Early Deficits in Dentate Circuit and Behavioral Pattern Separation after Concussive Brain Injury DOI Creative Commons

Lucas Corrubia,

Andrew Huang, Susan Nguyen

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: June 25, 2023

Abstract Traumatic brain injury leads to cellular and circuit changes in the dentate gyrus, a gateway hippocampal information processing. Intrinsic granule cell firing properties strong feedback inhibition are proposed as critical its ability generate unique representation of similar inputs by process known pattern separation. Here we evaluate impact on decorrelation temporally patterned slices behavioral discrimination spatial locations vivo one week after concussive lateral fluid percussion (FPI) mice. Despite posttraumatic increases perforant path evoked excitatory drive cells enhanced ΔFosB labeling, indicating sustained increase excitability, reliability spiking was not compromised FPI. Although continued effectively decorrelate output spike trains recorded response input sets FPI, their highly patterns reduced. In parallel, encoding novel object location task that involves inhibitory circuits impaired Injury induced separation were accompanied loss somatostatin expressing neurons hilus. Together, these data suggest early undermine temporal well locations, both which could contribute deficits episodic memory.

Language: Английский

Cellular and circuit features distinguish dentate gyrus semilunar granule cells and granule cells activated during contextual memory formation DOI Open Access

Laura Dovek,

Krista Marrero,

Edward Zagha

et al.

Published: Oct. 28, 2024

The dentate gyrus is critical for spatial memory formation and shows task related activation of cellular ensembles considered as engrams. Semilunar granule cells (SGCs), a sparse projection neuron subtype distinct from (GCs), were recently reported to be enriched among behaviorally activated neurons. However, the mechanisms governing SGC recruitment during their role in engram refinement remains unresolved. By examining neurons labeled contextual TRAP2 mice, we empirically tested competing hypotheses GC into ensembles. In support proposal that more excitable are preferentially recruited ensembles, SGCs showed greater sustained firing than GCs. Additionally, less adapting unlabeled SGCs. Our recordings did not reveal glutamatergic connections between GCs, providing evidence against driving local circuit feedforward excitation ensemble recruitment. Contrary leading hypothesis, there was little individual or neuronal supporting lateral inhibition Instead, pairs GCs within cohorts received temporally correlated spontaneous excitatory synaptic inputs labeled-unlabeled pairs, validating afferent selection. These findings challenge drive refinement, while intrinsic active properties preferential

Language: Английский

Citations

1
Mild Traumatic Brain Injury Affects Orexin/Hypocretin Physiology Differently in Male and Female Mice DOI
Rebecca T. Somach,

I Jean,

Anthony M. Farrugia

et al.

Journal of Neurotrauma, Journal Year: 2023, Volume and Issue: 40(19-20), P. 2146 - 2163

Published: July 21, 2023

Traumatic brain injury (TBI) is known to affect the physiology of neural circuits in several regions, which can contribute behavioral changes after injury. Disordered sleep a behavior that often seen TBI, but there little research into how affects circuitry contributes disrupted regulation. Orexin/hypocretin neurons (hereafter referred as orexin neurons) located lateral hypothalamus normally stabilize wakefulness healthy animals and have been suggested source dysregulated behavior. Despite this, few studies examined TBI neuron circuitry. Further, almost no animal included female animals. Here, we address these gaps by studying using

Language: Английский

Citations

3
Early deficits in dentate circuit and behavioral pattern separation after concussive brain injury DOI Creative Commons

Lucas Corrubia,

Andrew Huang, Susan Nguyen

et al.

Experimental Neurology, Journal Year: 2023, Volume and Issue: 370, P. 114578 - 114578

Published: Oct. 18, 2023

Traumatic brain injury leads to cellular and circuit changes in the dentate gyrus, a gateway hippocampal information processing. Intrinsic granule cell firing properties strong feedback inhibition are proposed as critical its ability generate unique representation of similar inputs by process known pattern separation. Here we evaluate impact on decorrelation temporally patterned slices behavioral discrimination spatial locations vivo one week after concussive lateral fluid percussion (FPI) mice. Despite posttraumatic increases perforant path evoked excitatory drive cells enhanced ΔFosB labeling, indicating sustained increase excitability, reliability spiking was not compromised FPI. Although continued effectively decorrelate output spike trains recorded response input sets FPI, their highly patterns reduced. In parallel, encoding novel object location task that involves inhibitory circuits impaired Injury induced separation were accompanied loss somatostatin expressing neurons hilus. Together, these data suggest early undermine temporal well locations, both which could contribute deficits episodic memory.

Language: Английский

Citations

1
Enhancing cognitive recovery in chronic traumatic brain injury through simultaneous allosteric modulation of α7 nicotinic acetylcholine and α5 GABAA receptors DOI

Alyssa F Balleste,

Akhila Sangadi,

David J. Titus

et al.

Experimental Neurology, Journal Year: 2024, Volume and Issue: 379, P. 114879 - 114879

Published: June 26, 2024

Language: Английский

Citations

0
Cellular and circuit features distinguish dentate gyrus semilunar granule cells and granule cells activated during contextual memory formation DOI Creative Commons

Laura Dovek,

Krista Marrero,

Edward Zagha

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 21, 2024

Abstract The dentate gyrus is critical for spatial memory formation and shows task related activation of cellular ensembles considered as engrams. Semilunar granule cells (SGCs), a sparse projection neuron subtype distinct from (GCs), were recently reported to be enriched among behaviorally activated neurons. However, the mechanisms governing SGC recruitment during their role in engram refinement remains unresolved. By examining neurons labeled contextual TRAP2 mice, we empirically tested competing hypotheses GC into ensembles. In support proposal that more excitable are preferentially recruited ensembles, SGCs showed greater sustained firing than GCs. Additionally, less adapting unlabeled SGCs. Our recordings did not reveal glutamatergic connections between GCs, providing evidence against driving local circuit feedforward excitation ensemble recruitment. Contrary leading hypothesis, there was little individual or neuronal supporting lateral inhibition Instead, pairs GCs within cohorts received temporally correlated spontaneous excitatory synaptic inputs labeled-unlabeled pairs, validating afferent selection. These findings challenge drive refinement, while intrinsic active properties preferential Impact Statement Evaluation semilunar cell involvement processing supports based on input characteristics revealing limited contribution refinement.

Language: Английский

Citations

0
Cellular and circuit features distinguish dentate gyrus semilunar granule cells and granule cells activated during contextual memory formation DOI Open Access

Laura Dovek,

Krista Marrero,

Edward Zagha

et al.

Published: Oct. 28, 2024

The dentate gyrus is critical for spatial memory formation and shows task related activation of cellular ensembles considered as engrams. Semilunar granule cells (SGCs), a sparse projection neuron subtype distinct from (GCs), were recently reported to be enriched among behaviorally activated neurons. However, the mechanisms governing SGC recruitment during their role in engram refinement remains unresolved. By examining neurons labeled contextual TRAP2 mice, we empirically tested competing hypotheses GC into ensembles. In support proposal that more excitable are preferentially recruited ensembles, SGCs showed greater sustained firing than GCs. Additionally, less adapting unlabeled SGCs. Our recordings did not reveal glutamatergic connections between GCs, providing evidence against driving local circuit feedforward excitation ensemble recruitment. Contrary leading hypothesis, there was little individual or neuronal supporting lateral inhibition Instead, pairs GCs within cohorts received temporally correlated spontaneous excitatory synaptic inputs labeled-unlabeled pairs, validating afferent selection. These findings challenge drive refinement, while intrinsic active properties preferential

Language: Английский

Citations

0
Early Deficits in Dentate Circuit and Behavioral Pattern Separation after Concussive Brain Injury DOI Creative Commons

Lucas Corrubia,

Andrew Huang, Susan Nguyen

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: June 25, 2023

Abstract Traumatic brain injury leads to cellular and circuit changes in the dentate gyrus, a gateway hippocampal information processing. Intrinsic granule cell firing properties strong feedback inhibition are proposed as critical its ability generate unique representation of similar inputs by process known pattern separation. Here we evaluate impact on decorrelation temporally patterned slices behavioral discrimination spatial locations vivo one week after concussive lateral fluid percussion (FPI) mice. Despite posttraumatic increases perforant path evoked excitatory drive cells enhanced ΔFosB labeling, indicating sustained increase excitability, reliability spiking was not compromised FPI. Although continued effectively decorrelate output spike trains recorded response input sets FPI, their highly patterns reduced. In parallel, encoding novel object location task that involves inhibitory circuits impaired Injury induced separation were accompanied loss somatostatin expressing neurons hilus. Together, these data suggest early undermine temporal well locations, both which could contribute deficits episodic memory.

Language: Английский

Citations

0