Deciphering agronomic traits, biochemical components, and color in unique green-seeded fenugreek (Trigonella foenum-graecum L.) genotypes

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 27, 2025

Fenugreek is a high-value legume known for its potential to enhance human health and combat variety of diseases metabolic disorders. This versatile crop has demonstrated promising therapeutic effects in managing obesity, diabetes, cancer, poor metabolism conditions that have become major global concerns. Despite the availability multiple pharmaceutical remedies these ailments market, often times heavy chemical doses are accompanied by side on body. To investigate agronomic traits, medicinal potential, color fenugreek seeds, this study was conducted identified genotypes with green seed (GSF1 GSF10), which can prevent progression aforementioned without hassle effects. Ten unique green-seeded (GSF) were compared five released varieties (yellow-seeded fenugreek; YSF1 YSF5) as check. The assessed during rabi season 3 consecutive years (2021-22 2023-24) semi-arid Eastern Plain Zone Rajasthan, India. findings exhibited agronomically GSF performed well, almost at par YSF. Harvest index (23.21 ± 0.37%) higher very marginal differences other traits. showed GSF6 nearly 1.5 2 insulinotropic 4-hydroxyisoleucine (0.90%) levels YSF genotypes. non-protein branched amino acid found seeds. GSF1 high concentration chlorophyll (0.45 mg/100 g), GSF10 low diosgenin 4-OHIle (261.80 g 0.85%, respectively), GSF9 total soluble sugars (TSS; 3.50%). Oil content, phenols, proteins be making it preferable over further revealed darkness directly related content associated lower TSS. Among studied genotypes, harvest maximum yield (2473.74 Kg/ha) genotype GSF8. superior GSF1, GSF6, GSF8, GSF9, developed hold future breeding initiatives, aimed boosting value, nutritional quality, productivity.

Language: Английский

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An overview of the nutritional composition, bioactivities and applications of Chinese yam (Dioscoreas Oppositae)

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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Targeting Histone Deacetylase 11 with a Highly Selective Inhibitor for the Treatment of MASLD

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

Abstract Metabolic dysfunction‐associated steatotic liver disease (MASLD) represents the most prevalent chronic disorder globally. Due to its intricate pathogenesis and current lack of efficacious pharmacological interventions, there is a pressing need discover novel therapeutic targets agents for MASLD treatment. Herein, it found that histone deacetylase 11 (HDAC11), subtype HDAC family, markedly overexpressed in both vitro vivo models MASLD. Furthermore, knockdown HDAC11 observed mitigate lipid accumulation hepatic cells. A highly selective inhibitor, B6 , which exhibits favorable pharmacokinetic property distribution, further designed synthesized. Integrating RNA‐seq data with experiments, inhibit de novo lipogenesis (DNL) promote fatty acid oxidation, thus mitigating pathological symptoms mice. Further omics analysis experiments reveal enhances phosphorylation AMPKα1 at Thr172 through inhibition HDAC11, consequently modulating DNL oxidation liver. In summary, this study identifies as potential target reports discovery inhibitor drug‐like properties treatment

Language: Английский

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Characterization of bioactive compounds in fenugreek genotypes in varying environments: diosgenin, trigonelline, and 4-hydroxyisoleucine

Frontiers in Plant Science, Journal Year: 2025, Volume and Issue: 16

Published: March 24, 2025

This study investigates the effects of irrigated and non-irrigated conditions on bioactive compound content in fenugreek ( Trigonella foenum-graecum ) across 31 diverse genotypes from various geographical regions. The was conducted at Atatürk University Research Extension Center, Türkiye (N 39°55’59.9”, E 41°14’10.6”, altitude 1789 m) during 2021 2022 growing seasons. levels diosgenin, trigonelline, 4-hydroxyisoleucine analyzed under were found to be significantly influenced by genotype, environment, their interaction (Genotype × Environment), with a highly significant effect observed p < 0.001 level. compounds included diosgenin (0.50-0.93%), trigonelline (5.22-13.65 mg g - ¹), (0.41-1.90%). Notably, such as Sivas/TR, Amasya/TR, Konya/TR Samsun/TR exhibited higher all conditions, while Spain, Malaysia, France, India showed irrigation. Variability observed, some showing stability different environmental conditions. A negative correlation between fenugreek. Furthermore, Principal Component Analysis (PCA) cluster analysis effective revealing genetic diversity, morphological differences, genotype adaptability. findings highlight potential for selecting superior breeding programs focused enhancing yields, especially varying irrigation research emphasizes critical role factors optimizing production health-benefiting

Language: Английский

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Advancements in Utilizing Natural Compounds for Modulating Autophagy in Liver Cancer: Molecular Mechanisms and Therapeutic Targets

Cells, Journal Year: 2024, Volume and Issue: 13(14), P. 1186 - 1186

Published: July 12, 2024

Autophagy, an intrinsic catabolic mechanism that eliminates misfolded proteins, dysfunctional organelles, and lipid droplets, plays a vital function in energy balance cytoplasmic quality control, addition to maintaining cellular homeostasis. Liver cancer such as hepatocellular carcinoma (HCC) is one of the most common causes deaths globally shows resistance several anticancer drugs. Despite rising incidence poor prognosis malignant HCC, underlying molecular mechanisms driving this aggressive remain unclear. Several natural compounds, phytochemicals dietary non-dietary origin, affect hepatocarcinogenesis signaling pathways vitro vivo, which may help prevent treat HCC cells. Current cells treatments include chemotherapy, radiation, surgery. However, these standard therapies have substantial side effects, combination therapy enhances effects for acceptable therapeutic benefit. Therefore, there need develop treatment strategies are more efficacious fewer adverse effects. Multiple genetic epigenetic factors responsible become resistant treatment. Autophagy contributes maintain homeostasis, activates autophagy biosynthesis mitochondrial regulation recycling. modifying autophagic would present promising opportunity identify novel current treatments. This comprehensive review illustrates how compounds demonstrate their anti-hepatocellular through autophagy.

Language: Английский

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Metabolomic and Transcriptomic Analyses Reveal the Molecular Mechanism Underlying the Massive Accumulation of Secondary Metabolites in Fenugreek (Trigonella foenum-graecum L.) Seeds

Genes, Journal Year: 2024, Volume and Issue: 15(3), P. 343 - 343

Published: March 7, 2024

Fenugreek (Trigonella foenum-graecum L.) is a traditional medicinal plant for treating human diseases that widely cultivated in many countries. However, the component and related metabolic pathways are still unclear. To understand changes expression of genes during seed development, this study employed metabolomic transcriptomic analyses integrative analysis to explore metabolites involved growth fenugreek. The antifungal activity fenugreek seeds was also analyzed. A total 9499 were identified positive ion mode, 8043 negative mode. Among them, main components fatty acyls, prenol lipids, steroids, steroid derivatives, flavonoids, isoflavonoids. these enriched pathways, top 20 "flavone flavonol biosynthesis", "isoflavonoid "flavonoid biosynthesis". 3,7-Di-O-methylquercetin, pseudobaptigenin, isoflavonoids, methylecgonine, alkaloids, derivatives most significantly upregulated metabolites. There 38,137 differentially expressed (DEGs) via analysis. According KEGG pathway enrichment analysis, 147 DEGs Ten six key enzymes found be three flavonoid alkaloid synthesis test revealed inhibitory effect ethanol extract on Alternaria tenuissima (Kunze)Wiltshire Magnaporthe oryzae. These findings further prove use botanical pesticides fruit has research value.

Language: Английский

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Role of functional foods in diabetes management

Nutrire, Journal Year: 2024, Volume and Issue: 50(1)

Published: Dec. 23, 2024

Language: Английский

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Caragana jubata ethanol extract ameliorates the symptoms of STZ-HFD-induced T2DM mice by PKC/GLUT4 pathway

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 339, P. 119171 - 119171

Published: Nov. 28, 2024

Language: Английский

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