Diagnostic delay of oral squamous cell carcinoma and the fear of diagnosis: A scoping review

Frontiers in Psychology, Journal Year: 2022, Volume and Issue: 13

Published: Nov. 3, 2022

The mortality rate of patients affected with oral squamous cell carcinoma (OSCC) has been stable in recent decades due to several factors, especially diagnostic delay, which is often associated a late stage diagnosis and poor prognosis. aims this paper were to: analyze delay OSCC discuss the various psychological factors OSCC, particular attention patient’s fear receiving news regarding their health; professional dynamics related decision-making processes cases suspected OSCC. A preliminary review literature focusing on was performed. Seven articles included ranging from 45 days approximately 6 months. Patients’ fears and, lesser degree, concerns dentists, found be still poorly investigated. On basis authors’ experience, development lesions unknown origin may generate different behaviors by clinicians, play key role distinct steps process. It crucial increase awareness inform about onset contemporaneously encourage experimental studies patients’ respect communication

Language: Английский

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Healthcare in England was affected by the COVID-19 pandemic across the pancreatic cancer pathway: A cohort study using OpenSAFELY-TPP

eLife, Journal Year: 2023, Volume and Issue: 12

Published: Aug. 10, 2023

Healthcare across all sectors, in the UK and globally, was negatively affected by COVID-19 pandemic. We analysed healthcare services delivered to people with pancreatic cancer from January 2015 March 2023 investigate effect of

Language: Английский

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Impact of the COVID‐19 pandemic on stage and incidence of head and neck cancer: A rapid review and meta‐analysis

Clinical Otolaryngology, Journal Year: 2024, Volume and Issue: 49(4), P. 363 - 375

Published: March 21, 2024

Abstract Objectives This rapid review aims to evaluate the impact of COVID‐19 pandemic on incidence head and neck cancer (HNC) stage distribution at diagnosis. Design Rapid meta‐analysis. Participants Comparative data for new HNC patients between a pre‐pandemic cohort (before March 2020) (after 2020 during lockdown period). Main Outcomes Measured Data tumour stage, incidence, referral pathway (number patient referrals), or workload levels treatments). were summarised as odds ratios (OR) with 95% confidence intervals (CI), related changes in numbers diagnoses, referrals, narrative synthesis. Results A total 31 reports included this review. Individually 16 out 23 studies did not show significant relative period. However, meta‐analysis revealed that diagnosed 16% more likely have nodal involvement (OR = 1.16; CI 1.00–1.35), 17% late overall 1.17; 1.01–1.36), 32% present advanced extent (T3 T4 stage) 1.32; 1.08–1.62). was extremely limited currently sufficient assess trends burden disease. Conclusions indicates pandemic, there upstaging diagnosis, suggesting provision care significantly affected.

Language: Английский

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Impact of the COVID-19 Pandemic on the Treatment of Head and Neck Cancers

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(5), P. 1424 - 1424

Published: Feb. 20, 2025

Background/Objectives: The COVID-19 pandemic led to unprecedented disruptions cancer care, including the care of head and neck cancer. Given necessity timely treatment for mucosal cancers, it is important understand how affected diagnosis, presentation, Methods: National Cancer Database was queried patients with primary number annual diagnoses days between diagnosis start end any were tracked over time from 2004 2020. Chi-square tests used compare differences in patient clinical demographic characteristics 2019 2020 provide most direct comparison. Multivariable linear regression logic analyses also three quality measures 2020: treatment, surgery postoperative radiation, radiation. Results: decreased (9.1%) during early stages pandemic, a larger decrease (12.4%) among receiving surgery. On multivariable analysis comparing 2019, shorter (2.3 days; 95% CI, 1.69 2.85 days), radiation less likely be delayed (OR, 0.91 greater than 42 surgery; 0.85 0.97). However, who black, female, older, or uninsured more experience delays. Conclusions: Overall, there no delays surgical pandemic. vulnerable groups, such as uninsured, at higher risk experiencing

Language: Английский

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RECENT ADVANCES IN THE DISCOVERY OF COPPER(II) COMPLEXES AS POTENTIAL ANTICANCER DRUGS

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 292, P. 117702 - 117702

Published: April 29, 2025

This review article offers a literature search of the most active, new copper (II) anticancer complexes based on nitrogen-containing ligands, reported in over past 5 years: from beginning 2019, until mid-2024. In modern world, cancer remains one deadliest diseases all. Although years ongoing research allowed us to better understand its nature, and thus aim more precisely at specific molecular targets pathways, many aspects remain unclear. Today, chemotherapy still forefront treatment. With ever-growing struggles overcome chemoresistance occurrence serious side effects, discovery new, selective active drugs is task an utmost importance. At same time, (II)-based compounds offer wide array biological activities valuable biochemical properties. provides update recent advances potential among five years.

Language: Английский

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Novel Approach to Improving Specialist Access in Underserved Populations with Suspicious Oral Lesions

Current Oncology, Journal Year: 2023, Volume and Issue: 30(1), P. 1046 - 1053

Published: Jan. 11, 2023

Late detection and specialist referral result in poor oral cancer outcomes globally. High-risk LRMU populations usually do not have access to medicine specialists, a specialty of dentistry, whose expertise includes the identification, treatment, management cancers. To overcome this barrier, there is an urgent need for novel, low-cost tele-health approaches expand low-resource, remote underserved individuals. The goal study was compare diagnostic accuracy versus in-person visits using telehealth platform consisting smartphone-based, intraoral camera custom software application. A total 189 subjects with suspicious lesions requiring biopsy (per standard care) were recruited consented. Each subject examined, risk factors recorded twice: once by on-site specialist, again offsite specialist. low-cost, smartphone-based paired application utilized perform synchronous video/still imaging factor assessment off-site Biopsies performed at later date following recommendations. study's results indicated that diagnosis showed high sensitivity (94%) moderate specificity (72%) when compared histological diagnosis, which did significantly differ from telediagnosis (sensitivity: 95%; specificity: 84%). These preliminary findings suggest utilizing tool may improve individuals lesions.

Language: Английский

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Head and neck cancer in the UK: what was the stage before COVID-19? UK cancer registries analysis (2011-2018)

BDJ, Journal Year: 2022, Volume and Issue: 233(9), P. 787 - 793

Published: Nov. 11, 2022

Abstract Introduction People who present with more advanced stage head and neck cancer (HNC) are associated poorer outcomes survival. The burden trends of HNC not fully known at the population level. UK national registries routinely collect data on diagnoses. Aims To describe in diagnosis HNCs across before COVID-19 pandemic. Methods Aggregated incidence were requested from four countries for ten most recent years available by subsite American Joint Commission Cancer classification. Additionally, Scotland age group, sex area-based socioeconomic deprivation category. Results Across UK, rates had increased, 59% patients having disease 2016-2018. England a lower proportion (58%) than Scotland, Wales or Northern Ireland (65-69%) where available. completeness improved over (87% 2018). Conclusion Prior to pandemic, diagnoses an comprised majority representing major challenge healthcare system.

Language: Английский

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Causes and impact of delays during the COVID‐19 pandemic on head and neck cancer diagnosis

Head & Neck, Journal Year: 2024, Volume and Issue: 46(9), P. 2197 - 2205

Published: April 25, 2024

Abstract Background The causes for delays during the COVID19 pandemic and their impact on head neck cancer (HNC) diagnosis staging are not well described. Methods Two cohorts were defined a priori review analysis—a Pre‐Pandemic cohort (June 1 to December 31, 2019) Pandemic 2020). Delays categorized as COVID‐19 related or not, clinician, patient, policy related. Results A total of 638 HNC patients identified including 327 in Cohort 311 Cohort. Patients had more N2‐N3 category (41% vs. 33%, p = 0.03), T3‐T4 (63% 50%, 0.002), stage III‐IV (71% 58%, < 0.001) disease. Several intervals treatment pathway significantly longer compared cohort. Among cohort, 146 (47%) experienced delay, with 112 pandemic; 80 (71%) clinician related, 15 (13%) patient 17 (15%) Conclusions higher disease at along diagnostic pathway, factors being most common cause delay.

Language: Английский

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Effects of COVID-19 pandemic on hospital visit of head and neck cancer patients

Auris Nasus Larynx, Journal Year: 2023, Volume and Issue: 50(6), P. 948 - 951

Published: April 17, 2023

Language: Английский

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Impact of the COVID-19 pandemic on the diagnosis and treatment of patients with head and neck cancer in Brandenburg and Berlin

HNO, Journal Year: 2023, Volume and Issue: 72(2), P. 90 - 101

Published: Dec. 20, 2023

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