Stiff Person Syndrome With Positive Anti-glutamic Acid Decarboxylase (GAD) Autoantibodies DOI Open Access

Najoua Maarad,

Mounia Rahmani,

Nazha Birouk

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 27, 2024

Stiff person syndrome (SPS) is a progressive autoimmune disorder characterized by muscle rigidity, frequent falls, and spasms, affecting primarily women. Recent advances have linked SPS to specific antibodies, such as anti-glutamic acid decarboxylase (GAD)-65, but effective treatments remain elusive. We report the case of 53-year-old female who developed chronic lower back pain, tingling paresthesias, rigidity in limbs. Electromyographic examination revealed spasms co-contractions, along with severe reactive upon touch. Imaging studies showed polymyomatous uterus no hypermetabolic lesions. She was diagnosed stiff positive anti-GAD65 autoantibodies. Patient treated methylprednisolone, oral corticosteroids, gabapentin, baclofen, alprazolam, immunoglobulins, rituximab, leading moderate improvement her condition. This aims highlight association between autoantibodies, emphasizing importance early diagnosis comprehensive management.

Language: Английский

Hematopoietic stem cell transplantation as rescue therapy for refractory autoimmune retinopathy: a case report DOI Creative Commons
Wendy Wong, Yvonne Loh, Hwei Wuen Chan

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 7, 2025

Autoimmune retinopathy (AIR) is a rare, potentially blinding retinal disease that remains challenging condition to manage when resistant conventional immune-modulatory approaches. We report clinical and electrophysiological improvement in 49-year-old patient who underwent an autologous hematopoietic stem cell transplant (aHSCT) for thymoma-associated AIR after experiencing progressive despite receiving periocular systemic steroids, mycophenolate mofetil, baricitinib, tacrolimus, bortezomib, rituximab, plasmapheresis, intravenous immunoglobulin. The aHSCT had two stages: (i) peripheral blood harvest following mobilization with cyclophosphamide granulocyte colony-stimulating factor, (ii) conditioning regimen cyclophosphamide, anti-thymocyte globulin high-dose therapy, followed by infusion of 5.74 million cells. Symptoms photopsia rapidly abated undergoing aHSCT, objective investigations structure function similarly demonstrated improvement. At 22 months' follow-up, she continued demonstrate the durability response. present suggests judiciously selected patients, HSCT may provide rescue option refractory AIR. Further cases are needed confirm these results.

Language: Английский

Citations

1
Stem cell therapies: a new era in the treatment of multiple sclerosis DOI Creative Commons
Lei Wu, Jing Lü,

Tianye Lan

et al.

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: May 9, 2024

Multiple Sclerosis (MS) is an immune-mediated condition that persistently harms the central nervous system. While existing treatments can slow its course, a cure remains elusive. Stem cell therapy has gained attention as promising approach, offering new perspectives with regenerative and immunomodulatory properties. This article reviews application of stem cells in MS, encompassing various types, therapeutic potential mechanisms, preclinical explorations, clinical research advancements, safety profiles applications, well limitations challenges, aiming to provide insights into treatment for MS.

Language: Английский

Citations

4
Stiff Person Spectrum Disorders—An Update and Outlook on Clinical, Pathophysiological and Treatment Perspectives DOI Creative Commons
Benjamin Vlad, Yujie Wang, Scott D. Newsome

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(9), P. 2500 - 2500

Published: Sept. 10, 2023

Stiff person spectrum disorders (SPSD) are paradigm autoimmune movement characterized by stiffness, spasms and hyperekplexia. Though rare, SPSD represent a not-to-miss diagnosis because of the associated disease burden treatment implications. After decades as an enigmatic orphan disease, major advances in our understanding evolving diseases have been made along with identification multiple autoantibodies. However, most important recent developments relate to recognition wider affection, beyond classic core motor symptoms, further insights into immunomodulatory symptomatic therapies. In this review, we summarize literature on clinical paraclinical spectrum, current pathophysiological understanding, well possibly future therapeutic strategies.

Language: Английский

Citations

9
Regenerative rehabilitation: a novel multidisciplinary field to maximize patient outcomes DOI Creative Commons
Chunchu Deng,

Fatima Aldali,

Hongmei Luo

et al.

Medical Review, Journal Year: 2024, Volume and Issue: 4(5), P. 413 - 434

Published: June 13, 2024

Abstract Regenerative rehabilitation is a novel and rapidly developing multidisciplinary field that converges regenerative medicine science, aiming to maximize the functions of disabled patients their independence. While provides state-of-the-art technologies shed light on difficult-to-treated diseases, offers interventions improve positive effects medicine. However, scientists professionals focus aspects without enough exposure advances in each other’s field. This disconnect has impeded development this Therefore, review first introduces cutting-edge such as stem cell technology, tissue engineering, biomaterial gene editing, computer sciences promote progress pace medicine, followed by summary preclinical studies examples clinical investigations integrate rehabilitative methodologies into Then, challenges are discussed, possible solutions provided for future directions. We aim provide platform clinicians other areas better understand rehabilitation, thus contributing translation management innovative reliable therapies.

Language: Английский

Citations

1
Strategies to improve autoimmune neurological diseases treatment DOI Creative Commons
Frank Leypoldt

Revue Neurologique, Journal Year: 2024, Volume and Issue: 180(9), P. 888 - 894

Published: Sept. 19, 2024

There is a need to improve therapies in autoimmune neurologic conditions. Yet which strategic objectives are required, what the barriers that stand before reaching them, and options address them? This article tries summarize these their respective barriers. It discusses difficulties identifying molecular targets, biomarker-defined subgroups, merits of upstream downstream-targeted therapies, develop autoreactivity-specific treatments contrast cell-type specific "evidence-bottleneck". Its focus on autoantigen-specific autoimmunopathies neurology. also role B- T-cells neurology how can be exploited therapeutically. Finally, it argues for improved training present future neuroimmunologists.

Language: Английский

Citations

1
Stem Cell Therapy in Neuroimmunologic Diseases DOI
Gauruv Bose,

Mark S. Freedman

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

Citations

0
HSCT for stiff person syndrome and myasthenia gravis DOI
Vincenzo Daniele Boccia, Giacomo Boffa, Matilde Inglese

et al.

Handbook of clinical neurology, Journal Year: 2024, Volume and Issue: unknown, P. 239 - 247

Published: Jan. 1, 2024

Language: Английский

Citations

0
In persons with CIDP, auto-HSCT can be conducted fully on an outpatient basis and induces significant clinical responses: A prospective study in a single center DOI

Merittzel Abigail Montes-Robles,

Moisés Manuel Gallardo‐Pérez,

Edgar J. Hernández-Flores

et al.

Transplant Immunology, Journal Year: 2023, Volume and Issue: 81, P. 101944 - 101944

Published: Oct. 20, 2023

Language: Английский

Citations

1
Stiff Person Syndrome With Positive Anti-glutamic Acid Decarboxylase (GAD) Autoantibodies DOI Open Access

Najoua Maarad,

Mounia Rahmani,

Nazha Birouk

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 27, 2024

Stiff person syndrome (SPS) is a progressive autoimmune disorder characterized by muscle rigidity, frequent falls, and spasms, affecting primarily women. Recent advances have linked SPS to specific antibodies, such as anti-glutamic acid decarboxylase (GAD)-65, but effective treatments remain elusive. We report the case of 53-year-old female who developed chronic lower back pain, tingling paresthesias, rigidity in limbs. Electromyographic examination revealed spasms co-contractions, along with severe reactive upon touch. Imaging studies showed polymyomatous uterus no hypermetabolic lesions. She was diagnosed stiff positive anti-GAD65 autoantibodies. Patient treated methylprednisolone, oral corticosteroids, gabapentin, baclofen, alprazolam, immunoglobulins, rituximab, leading moderate improvement her condition. This aims highlight association between autoantibodies, emphasizing importance early diagnosis comprehensive management.

Language: Английский

Citations

0