Pituitary, Journal Year: 2024, Volume and Issue: 27(2), P. 204 - 212
Published: Feb. 12, 2024
Language: Английский
Annals of Pediatric Endocrinology & Metabolism, Journal Year: 2023, Volume and Issue: 28(2), P. 87 - 97
Published: June 28, 2023
Cushing disease (CD) is the main cause of endogenous syndrome (CS) and produced by an adrenocorticotropic hormone (ACTH)-producing pituitary adenoma. Its relevance in pediatrics due to retardation both growth developmental processes because hypercortisolism. In childhood, features CS are facial changes, rapid or exaggerated weight gain, hirsutism, virilization, acne. Endogenous hypercortisolism should be established after exogenous has been ruled out based on 24-hour urinary free cortisol, midnight serum salivary dexamethasone suppression test; that, ACTH dependence established. The diagnosis confirmed pathology. goal treatment normalize cortisol level reverse signs symptoms. Treatment options include surgery, medication, radiotherapy, combined therapy. CD represents a challenge for physicians owing its multiple associated conditions involving pubertal development; thus, it important achieve early order control improve prognosis. rarity pediatric patients led have limited experience management. objective this narrative review summarize current knowledge about pathophysiology, diagnosis, population.
Language: Английский
Citations
9
Journal of Pathology Informatics, Journal Year: 2023, Volume and Issue: 15, P. 100354 - 100354
Published: Nov. 22, 2023
Anatomical pathology is undergoing its third revolution, transitioning from analogical to digital and incorporating new artificial intelligence technologies into clinical practice. Aside classification, detection, segmentation models, predictive models are gaining traction since they can impact diagnostic processes laboratory activity, lowering consumable usage turnaround time. Our research aimed create a deep-learning model generate synthetic Ki-67 immunohistochemistry Haematoxylin Eosin (H&E) stained images. We used 175 oral squamous cell carcinoma (OSCC) the University Federico II's Pathology Unit's archives train our 4 Tissue Micro Arrays (TMAs). sectioned one slide each TMA, first with H&E then re-stained anti-Ki-67 (IHC). In digitised slides, cores were disarrayed, matching of 2 aligned construct dataset Pix2Pix algorithm convert images IHC. Pathologists could recognise in only half cases specially designed likelihood test. Hence, produced realistic next QuPath quantify IHC positivity, achieving remarkable levels agreement between genuine Furthermore, categorical analysis employing 3 positivity cut-offs (5%, 10%, 15%) revealed high positive-predictive values. promising tool for collecting information directly on reducing demand improving patient management. It also valuable option smaller laboratories easily quickly screen bioptic samples prioritise them workflow.
Language: Английский
Citations
7
Medicina, Journal Year: 2022, Volume and Issue: 58(8), P. 1071 - 1071
Published: Aug. 8, 2022
Functioning gonadotroph adenomas (FGAs) are rare tumors, as the overwhelming majority of tumors clinically silent. Literature is based on case reports and small series. Gonadotroph poorly differentiated produce secrete hormones inefficiently, but in exceptional cases, they cause clinical syndromes due to hypersecretion intact gonadotropins. The spectrum endocrine dysfunction includes an exaggerated response ovaries characterized ovarian hyperstimulation syndrome (OHSS) premenopausal females adolescent girls, testicular enlargement males, isosexual precocious puberty children. Transsphenoidal surgery removal tumor reduces hormonal hypersecretion, improves dysfunction, provides tissue for further analysis. Medical therapies (somatostatin analogues, dopamine agonists, GnRH agonists/antagonists) partially or totally ineffective many especially with respect antitumor effect. This review aims update recent literature these functioning highlight their therapeutic management.
Language: Английский
Citations
12
World Neurosurgery, Journal Year: 2024, Volume and Issue: 190, P. 371 - 385.e1
Published: July 20, 2024
Language: Английский
Citations
2
Molecular Neurobiology, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 2, 2024
Exosomal long noncoding RNAs (lncRNAs), which are highly expressed in tumor-derived exosomes, regulate various cellular behaviors such as cell proliferation, metastasis, and glycolysis by facilitating intercellular communication. Here, we explored the role regulatory mechanism of exosomal lncRNAs pituitary adenomas (PA). We isolated exosomes from PA cells, performed vitro vivo assays to examine their effect on cells. In addition, conducted RNA pull-down, immunoprecipitation, co-immunoprecipitation, ubiquitination investigate downstream AFAP1-AS1. Exosomes cells augmented mobility, Moreover, AFAP1-AS1 was significantly enriched these stimulated growth, migration, invasion, vitro, well tumor metastasis vivo. It also enhanced binding affinity between Hu antigen R (HuR) SMAD-specific E3 ubiquitin protein ligase 1 (SMURF1), resulting HuR degradation accompanied expression hexokinase 2 (HK2) pyruvate kinase M2 (PKM2). overexpression alleviated AFAP1-AS1-mediated promotion effects. These findings indicate that modulated SMURF1-mediated upregulate HK2 PKM2 expression, thereby enhancing glucose metabolism. This suggests targeting may be a potential strategy for treatment PA.
Language: Английский
Citations
2
Obesity and metabolism, Journal Year: 2024, Volume and Issue: 21(2), P. 215 - 249
Published: June 26, 2024
We recommend acromegaly to be ruled in all patients with characteristic changes appearance (A3). In without appearance, we rule out acromegaly, if several clinical signs suspicious for are present (B3). pituitary adenoma prolactin-secreting adenomas (C4). For laboratory confirmation of measure serum insulin-like growth factor-1 (IGF-1, somatomedin C) level obvious and/or a moderate increase IGF-1 levels (IGF-1 index less than 1.3), assess the response somatotropic hormone (GH) hyperglycemia (GH during an oral glucose tolerance test) biochemically confirmed magnetic resonance imaging gland intravenous contrast is recommended size, location and pattern blood glycated hemoglobin prolactin adenoma, transnasal transsphenoidal adenomectomy as first-line treatment patient’s consent given there no contraindications (A1). whom neurosurgical indicated, surgical intervention medical centers, specializing diseases, by neurosurgeons who perform at least 50 such operations per year that morphological immunohistochemical examination removed performed do not routine therapy before surgery mean reduce tumor size (B2). indicated or ineffective while patient awaiting effect radiation therapy, Long-acting first-generation somatostatin analogues drug acromegaly. case partial/complete resistance intolerance analogs, pegvisomant second-line starting from single dose 40–80 mg day subcutaneously, then continue injections 10 15 monitoring after 4–6 weeks adjustment necessary levels, initiate cabergoline monotherapy or, analogs ineffective, combination them disease remains active treatment, unavailable, intolerable repeated inappropriate, it A multidisciplinary approach management complications (C3).
Language: Английский
Citations
2
World Neurosurgery, Journal Year: 2023, Volume and Issue: 182, P. e98 - e106
Published: Nov. 22, 2023
Language: Английский
Citations
5
Pituitary, Journal Year: 2023, Volume and Issue: 26(4), P. 340 - 351
Published: June 29, 2023
Language: Английский
Citations
4
World Neurosurgery, Journal Year: 2024, Volume and Issue: 189, P. e1092 - e1097
Published: July 18, 2024
Language: Английский
Citations
1
Neurosurgery, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 7, 2024
Stereotactic radiosurgery (SRS) represents an effective treatment for nonfunctioning pituitary adenomas (NFPAs). However, no data have yet been published regarding results of SRS on NFPAs after multiple previous resections.
Language: Английский
Citations
1