Study of association of the polymorphism rs1799883 of the <i>FABP2</i> gene in children with bronchial asthma associated with obesity DOI Creative Commons
R. S. Telepneva, Г. П. Евсеева, Е Б Наговицына

et al.

Bulletin physiology and pathology of respiration, Journal Year: 2023, Volume and Issue: 89, P. 79 - 87

Published: Sept. 28, 2023

Introduction. Currently, there is a separate phenotype “bronchial asthma – obesity”, manifested by more severe course of the disease, low rates achieving control, resistance to basic therapy. Asthma, like obesity, recognized as classic example multifactorial diseases, which are based on rather complex gene network. The active search for genetic markers characterizing individual characteristics human metabolism continues. Of particular interest genes involved in regulation fat and carbohydrate metabolism. Aim. Analysis associations polymorphic loci Ala54Thr (G163A) FABP2 with bronchial varying severity control children. Materials methods. 161 children remission were examined continuous sampling method, 59 patients obesity 1-3 degrees without concomitant endocrine pathology. examination included general clinical, functional, instrumental level was determined according GINA criteria (2018). biochemical study carried out an automatic analyzer SAPPHIRE 400 (Japan). polymorphisms real-time polymerase chain reaction using sets “Metabolism” (Research Production Company “Litekh”, Moscow) CFX-96 Biorat device (USA). Results. We have not identified presence obesity. It that asthma, frequency carrying homozygous genotype Thr/Thr minor allele Thr increased 1.5 times compared group (OR 9.043; 95%CI [2,093–39,073], p=0.0011 OR 2.946; [1,698‒5,111], p=0.001, respectively), carriage rare A risk uncontrolled 2.42; [1.23‒4.79], p=0.03 1.75; [1,119‒2,736], p=0.01), Ala/Ala frequent Ala detected often associated 2.176; [1.001‒4.727], p=0.0008 2.378; [1.495‒3.780], p=0.0002, respectively). Conclusion. Although we it has been shown Ala54Thr+Thr54Тhr genotypes significantly higher glucose levels (4.9±0.06 mmol/L carriers Ala54Ala 4.0±0.06 mmol/L, p<0.001), cholesterol (4.8±0.4 3.93±0.1 p<0.05) density lipoproteins (2.55±0.09 2.26±0.1 p<0.05). There obvious need further investigation effect polymorphism indicators lipid metabolism, depending nature diets. These issues require part probable cause-and-effect relationships creation personalized programs variants.

Language: Английский

The rs7552841 polymorphism of protein convertase subtilisin/kexin type 9 is associated with cardiac tissue damage biomarkers and lipid profile in Tunisian patients with coronary artery disease DOI
R. Chaaba, Sounira Mehri,

Chahrazed Aguel

et al.

Gene Reports, Journal Year: 2024, Volume and Issue: unknown, P. 102031 - 102031

Published: Sept. 1, 2024

Language: Английский

Citations

0
The association between N-nitrosamines exposure and lipid metabolism in the high incidence area of esophageal cancer: A case-control analysis DOI
Hu Zhang, Chao Zhao,

Yucheng Wang

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 363, P. 125271 - 125271

Published: Nov. 7, 2024

Language: Английский

Citations

0
Fatty Acids of Erythrocyte Membranes and Blood Serum as Possible Predictors of Exacerbation in Patients with Inflammatory Bowel Diseases DOI Creative Commons
М. В. Кручинина, М. Ф. Осипенко,

A. I. Valuyskikh

et al.

Russian Journal of Gastroenterology Hepatology Coloproctology, Journal Year: 2024, Volume and Issue: 34(6), P. 28 - 41

Published: Dec. 30, 2024

Aim: to study the levels of fatty acids in membranes erythrocytes and blood serum patients with inflammatory bowel diseases (IBD) examined over time, as possible predictors exacerbation disease. Materials methods. Over a period 6–12 months, 24 (mean age — 38.2 ± 4.4 years) IBD moderate mild severity disease were examined, which 10 had ulcerative colitis, Crohn’s disease, 4 unclassified colitis: first examination was acute stage, second remission stage. In 48 additionally (25 15 8 colitis), course monitored next 12 months. The comparison group included 53 people comparable main groups age. composition (FAs) carried out using gas chromatograph mass spectrometry system based on three quadrupoles Agilent 7000B (Agilent Technologies Inc., USA). Results. have higher total content saturated (SFAs) erythrocyte compared control ( p = 0.006), and, contrary, lower unsaturated (UFAs) 0.005), mainly due polyunsaturated FAs (PUFAs) 0.026), namely omega-6 PUFAs 0.011).Remission is associated an increase level number SFAs margaric C17:0 0.024), arachidic acid (C20:0) 0.0001 0.019, respectively), decrease monounsaturated 0.022), concentration both omega-3 0.0008) 0.033) healthy individuals.The stage time stearic FA C18:0 SFA/UFA 0.034) SFA/PUFA 0.039) ratios membranes, C20:0 0.008), UFAs eicosapentaenoic C20:5n-3 0.0023), eicosadienoic C20:2n-6 0.0027), hexadecadienoic C16:2n-6 docosatetraenoic C22:4n-6 0.008) alpha-linolenic C18:3n-3 0.039).A combined “panel” acids, including C20:2n-6, serum, provided AUC 0.683 (95 % CI: 0.500–0.844), sensitivity 91.4 %, specificity 68.3 %.Levels C20:5n-3, C18:0, C16:2n-6, C22:4n-6, used biomarkers development who remission, predicted after 2–4 months case maximally changed FAs, 6–8 moderately maintaining for minimally levels. Conclusion. Fatty should be considered promising markers further studies related diagnosis prediction IBD.

Language: Английский

Citations

0
AIE‐Based Sensor Combination for Oleic Acid/Elaidic Acid Discriminating and Sensing DOI Open Access

Yufeng Shi,

Xiaofei Yang,

Shengnan Wu

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(32)

Published: Aug. 23, 2024

Abstract Two aggregation induced emission molecules ( TPE‐MZ and QM‐Py‐TPE ) have been synthesized characterized. Similar to conventional AIE based molecules, both displayed good sensitivity towards water fraction viscosity of dispersing medium. The fluorescent intensity gradually reduced with increasing concentration oleic acid elaidic within the range 0.2–5 mM. inflection points maximum for were observed at 1.40 0.80 mM, respectively. corresponding 1.80 2.00 mM acid, Sensor combination : =2 1) emitted pink yellow fluorescence in acid. Fluorescent ratio I 646 /I 508 sensor acceptable linear relationship (R 2 =0.9826) (within 4 mM). Thus, was capable naked‐eye discriminating quantitively sensing.

Language: Английский

Citations

0
Punicalagin relieves lipotoxic injuries on pancreatic β-cells via regulating the oxidative stress and endoplasmic reticulum stress-mediated apoptosis DOI
Ning Wang, Kexin Yang, Jun Wang

et al.

In Vitro Cellular & Developmental Biology - Animal, Journal Year: 2023, Volume and Issue: 59(8), P. 575 - 585

Published: Sept. 1, 2023

Language: Английский

Citations

0
Study of association of the polymorphism rs1799883 of the <i>FABP2</i> gene in children with bronchial asthma associated with obesity DOI Creative Commons
R. S. Telepneva, Г. П. Евсеева, Е Б Наговицына

et al.

Bulletin physiology and pathology of respiration, Journal Year: 2023, Volume and Issue: 89, P. 79 - 87

Published: Sept. 28, 2023

Introduction. Currently, there is a separate phenotype “bronchial asthma – obesity”, manifested by more severe course of the disease, low rates achieving control, resistance to basic therapy. Asthma, like obesity, recognized as classic example multifactorial diseases, which are based on rather complex gene network. The active search for genetic markers characterizing individual characteristics human metabolism continues. Of particular interest genes involved in regulation fat and carbohydrate metabolism. Aim. Analysis associations polymorphic loci Ala54Thr (G163A) FABP2 with bronchial varying severity control children. Materials methods. 161 children remission were examined continuous sampling method, 59 patients obesity 1-3 degrees without concomitant endocrine pathology. examination included general clinical, functional, instrumental level was determined according GINA criteria (2018). biochemical study carried out an automatic analyzer SAPPHIRE 400 (Japan). polymorphisms real-time polymerase chain reaction using sets “Metabolism” (Research Production Company “Litekh”, Moscow) CFX-96 Biorat device (USA). Results. We have not identified presence obesity. It that asthma, frequency carrying homozygous genotype Thr/Thr minor allele Thr increased 1.5 times compared group (OR 9.043; 95%CI [2,093–39,073], p=0.0011 OR 2.946; [1,698‒5,111], p=0.001, respectively), carriage rare A risk uncontrolled 2.42; [1.23‒4.79], p=0.03 1.75; [1,119‒2,736], p=0.01), Ala/Ala frequent Ala detected often associated 2.176; [1.001‒4.727], p=0.0008 2.378; [1.495‒3.780], p=0.0002, respectively). Conclusion. Although we it has been shown Ala54Thr+Thr54Тhr genotypes significantly higher glucose levels (4.9±0.06 mmol/L carriers Ala54Ala 4.0±0.06 mmol/L, p<0.001), cholesterol (4.8±0.4 3.93±0.1 p<0.05) density lipoproteins (2.55±0.09 2.26±0.1 p<0.05). There obvious need further investigation effect polymorphism indicators lipid metabolism, depending nature diets. These issues require part probable cause-and-effect relationships creation personalized programs variants.

Language: Английский

Citations

0