Structural insight into the mechanisms and interacting features of endocrine disruptor Bisphenol A and its analogs with human estrogen-related receptor gamma

Environmental Pollution, Journal Year: 2024, Volume and Issue: 345, P. 123549 - 123549

Published: Feb. 11, 2024

Bisphenol A (BPA) is a very important chemical from the commercial perspective. Many useful products are made it, so its production increasing day by day. It widely known that and analogs present in environment they enter our body through various routes on daily basis as we use things of this lives. BPA has already been reported to be an endocrine disruptor. Studies have shown binds strongly human estrogen-related receptor gamma (ERRγ) target it. This study seeks understand how it interacts with ERRγ. Molecular docking ERRγ was performed, estradiol taken reference. Then, physico-chemical toxicological analysis compounds performed. Subsequently, dynamic behavior ERRγ-BPA compound complexes studied molecular dynamics simulations over 500 ns, using simulated data, their binding energies were again calculated MM-PBSA method. We observed affinity much higher than estradiol, apart being toxic, can easily absorbed physicochemical properties similar those oral medicines. Therefore, facilitates understanding structure–activity relationship provides information about key amino acid residues interact compounds, which helpful design competitive inhibitors interrupt interaction In addition, will also developing new therapeutics.

Language: Английский

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Investigating the impact of endocrine-disrupting compounds on antepartum mental health at the Nexus of genetic insights and maternal-fetal outcomes: A prospective study

General Hospital Psychiatry, Journal Year: 2025, Volume and Issue: 94, P. 174 - 183

Published: March 13, 2025

Language: Английский

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Levels of parabens and bisphenols in personal care products and urinary concentrations in Indian young adult women: Implications for human exposure and health risk assessment

Chemosphere, Journal Year: 2022, Volume and Issue: 297, P. 134028 - 134028

Published: Feb. 23, 2022

Language: Английский

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A Role for Gene-Environment Interactions in Autism Spectrum Disorder Is Supported by Variants in Genes Regulating the Effects of Exposure to Xenobiotics

Frontiers in Neuroscience, Journal Year: 2022, Volume and Issue: 16

Published: May 19, 2022

Heritability estimates support the contribution of genetics and environment to etiology Autism Spectrum Disorder (ASD), but a role for gene-environment interactions is insufficiently explored. Genes involved in detoxification pathways physiological permeability barriers (e.g., blood-brain barrier, placenta respiratory airways), which regulate effects exposure xenobiotics during early stages neurodevelopment when immature brain extremely vulnerable, may be particularly relevant this context. Our objective was identify genes regulation xenobiotic or function (the XenoReg genes) presenting predicted damaging variants subjects with ASD, understand their interaction patterns ubiquitous previously implicated disorder. We defined panel 519 through literature review database queries. Large ASD datasets were inspected silico Single Nucleotide Variants (SNVs) (N = 2,674 subjects) Copy Number (CNVs) 3,570 genes. queried Comparative Toxicogenomics Database (CTD) pairs between xenobiotics. The interrogation gene identified 77 high evidence according pre-specified prioritization criteria. These include 47 encoding enzymes 30 proteins barrier function, among 15 are previous reported candidates ASD. CTD query revealed 397 these 80% (48/60) analyzed top interacting were, respectively, CYP1A2, ABCB1, ABCG2, GSTM1, CYP2D6 benzo-(a)-pyrene, valproic acid, bisphenol A, particulate matter, methylmercury, perfluorinated compounds. Individuals carrying likely have less efficient systems impaired barriers. They can therefore susceptible life xenobiotics, elicit neuropathological mechanisms brain, such as epigenetic changes, oxidative stress, neuroinflammation, hypoxic damage, endocrine disruption. As environmental factors mitigated individuals risk variants, work provides new perspectives personalized prevention health management policies

Language: Английский

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Exposure to endocrine disrupting chemicals (bisphenols, parabens, and triclosan) and their associations with preterm birth in humans

Reproductive Toxicology, Journal Year: 2024, Volume and Issue: 125, P. 108580 - 108580

Published: March 24, 2024

Language: Английский

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Exposure to UV-B filter octylmethoxycinnamate and human health effects: Focus on endocrine disruptor actions

Chemosphere, Journal Year: 2024, Volume and Issue: 358, P. 142218 - 142218

Published: May 2, 2024

Human skin is the first line of photoprotection against UV radiation. However, despite having its defence mechanisms, that exerts not enough. To protect human skin, inclusion filters in cosmetic industry has grown significantly as a strategy. Octylmethoxycinnamate, also designated by octinoxate, or 2-ethylhexyl-4-methoxycinnamate (CAS number: 5466-77-3) one most widely used UV-B filter industry. The toxic effects OMC have alarmed public, but there still no consensus scientific community about use. This article aims to provide an overview filters' photoprotection, emphasizing and possible negative it may on public health. Moreover, current legislation will be addressed. In summary, recommendations should rethought assess their risk-benefit, since existing literature warns us endocrine-disrupting OMC. Further studies focus toxicity alone, mixture consider degradation products, improve knowledge risk assessment EDC.

Language: Английский

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Exploring novel insights into the molecular mechanisms underlying Bisphenol A-induced toxicity: A persistent threat to human health

Environmental Toxicology and Pharmacology, Journal Year: 2024, Volume and Issue: 108, P. 104467 - 104467

Published: May 17, 2024

Language: Английский

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Fetoplacental vasculature as a model to study human cardiovascular endocrine disruption

Molecular Aspects of Medicine, Journal Year: 2021, Volume and Issue: 87, P. 101054 - 101054

Published: Nov. 25, 2021

Language: Английский

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Bisphenol A, Bisphenol F, and Bisphenol S: The Bad and the Ugly. Where Is the Good?

Life, Journal Year: 2021, Volume and Issue: 11(4), P. 314 - 314

Published: April 3, 2021

Background: Bisphenol A (BPA), a reprotoxic and endocrine-disrupting chemical, has been substituted by alternative bisphenols such as bisphenol F (BPF) S (BPS) in the plastic industry. Despite their detection placenta amniotic fluids, effects of on human placental cells have not characterized. Our objective was to explore vitro compare toxicity BPA its substitutes BPF BPS highlight potential risks for then pregnancy. Methods: Human (JEG-Tox cells) were incubated with BPA, BPF, 72 h. Cell viability, cell death, degenerative P2X7 receptor caspases activation, chromatin condensation assessed using microplate cytometry fluorescence microscopy. Results: Incubation or associated activation condensation. induced more caspase-1, caspase-9, caspase-3 than BPS. Only enhanced caspase-8 activity. Conclusions: are all toxic cells, being common key element. substitution does appear be safe health, particularly pregnant women fetuses.

Language: Английский

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Isoflavones alter male and female fertility in different development windows

Biomedicine & Pharmacotherapy, Journal Year: 2021, Volume and Issue: 140, P. 111448 - 111448

Published: June 12, 2021

Isoflavones are a group of secondary metabolites found in plants belonging to the class phytoestrogens. These, because they have chemical structure similar endogenous hormone 17β-estradiol, act as endocrine disruptors over different development window periods. This study aimed evaluate male and female reproductive systems' responses when exposed isoflavones during window. It is characterized bibliographic review, built after analyzing clinical preclinical articles indexed English, Portuguese, Spanish published last ten years. The isoflavones, aglycone or glucosides, essential therapeutic properties relief postmenopausal symptoms women, reduce proliferation cancers, addition being antioxidants. On other hand, can still behave way binding receptors acting gestational period until pre-puberty, negatively affecting system. effects on reproduction not dose-response but influenced by type isoflavone period. There variations serum concentration hormones action their negative feedback hypothalamic-pituitary-testicular axis males. Reproductive functions also affected spermatogenesis, such decreased sperm count, lower performance, reduced litter size, low production, seminal vesicle size. In females, puberty reached later, irregular estrous cycle, weight ovary, uterus, levels estradiol progesterone, fertility, interrupted fertility. At end analysis selected publications, it be concluded that despite beneficial face pathologies, unknown consumption doses types food damage individuals. Therefore, further studies must carried out elucidate usual safe analyzed phytoestrogen. Greater control insertion foods targeted at pediatric consumers should implemented we adequate safety.

Language: Английский

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