Gold Nanoparticles for Drug Delivery and Cancer Therapy

Applied Sciences, Journal Year: 2020, Volume and Issue: 10(11), P. 3824 - 3824

Published: May 31, 2020

Nanomaterials are popularly used in drug delivery, disease diagnosis and therapy. Among a number of functionalized nanomaterials such as carbon nanotubes, peptide nanostructures, liposomes polymers, gold nanoparticles (Au NPs) make excellent anticancer agent carriers biomedical cancer therapy application. Recent advances synthetic technique improved the surface coating Au NPs with accurate control particle size, shape chemistry. These much easier safer to be applied patient’s tumor. Although many studies on have been published, more results pipeline due rapid development nanotechnology. The purpose this review is assess how novel fabricated by can impact applications delivery Moreover, explores viability, property cytotoxicity various NPs.

Language: Английский

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Nanocatalyst‐Mediated Chemodynamic Tumor Therapy

Advanced Healthcare Materials, Journal Year: 2021, Volume and Issue: 11(2)

Published: Nov. 9, 2021

Abstract Traditional tumor treatments, including chemotherapy, radiotherapy, photodynamic therapy, and photothermal are developed used to treat different types of cancer. Recently, chemodynamic therapy (CDT) has been emerged as a novel cancer therapeutic strategy. CDT utilizes Fenton or Fenton‐like reaction generate highly cytotoxic hydroxyl radicals (•OH) from endogenous hydrogen peroxide (H 2 O ) kill cells, which displays promising potentials for treatment. However, the low catalytic efficiency off‐target side effects limit biomedical application CDT. In this regard, various strategies implemented potentiate against tumor, retrofitting microenvironment (e.g., increasing H level, decreasing reductive substances, reducing pH), enhancing nanocatalysts, other strategies. This review aims summarize development these recent progresses nanocatalyst‐mediated antitumor application. The future trend challenges also discussed.

Language: Английский

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Green Synthesis of Gold Nanoparticles Using Plant Extracts as Beneficial Prospect for Cancer Theranostics

Molecules, Journal Year: 2021, Volume and Issue: 26(21), P. 6389 - 6389

Published: Oct. 22, 2021

Gold nanoparticles (AuNPs) have been widely explored and are well-known for their medical applications. Chemical physical synthesis methods a way to make AuNPs. In any case, the hunt other more ecologically friendly cost-effective large-scale technologies, such as environmentally biological processes known green synthesis, has gaining interest by worldwide researchers. The international focus on nanotechnology research resulted in various nanomaterials being used physiologically acceptable Several advantages over conventional chemical (simple, one-step approach synthesize, cost-effectiveness, energy efficiency, biocompatibility) drawn scientists’ attention exploring of AuNPs exploiting plants’ secondary metabolites. Biogenic approaches, mainly plant-based metal nanoparticles, chosen ideal strategy due environmental vivo safety, well ease synthesis. this review, we reviewed use synthesized treatment cancer utilizing phytochemicals found plant extracts. This article reviews producing AuNPs, characterization discusses physiochemical properties. study also recent breakthroughs achievements using different mechanisms action, reactive oxygen species (ROS), mediated mitochondrial dysfunction caspase activation, leading apoptosis, etc., anticancer cytotoxic effects. Understanding underlying therapeutic efficacy will aid developing personalized medicines treatments potential strategy.

Language: Английский

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Multifunctional Gold Nanoparticles for Improved Diagnostic and Therapeutic Applications: A Review

Nanoscale Research Letters, Journal Year: 2021, Volume and Issue: 16(1)

Published: Dec. 1, 2021

Abstract The medical properties of metals have been explored for centuries in traditional medicine the treatment infections and diseases still practiced to date. Platinum-based drugs are first class metal-based be clinically used as anticancer agents following approval cisplatin by United States Food Drug Administration (FDA) over 40 years ago. Since then, more with health benefits approved clinical trials. Interestingly, when these reduced metallic nanoparticles, they displayed unique novel that were superior their bulk counterparts. Gold nanoparticles (AuNPs) among FDA-approved shown great promise a variety roles medicine. They drug delivery, photothermal (PT), contrast, therapeutic, radiosensitizing, gene transfection agents. Their biomedical applications reviewed herein, covering potential use disease diagnosis therapy. Some AuNP-based systems trials also discussed, well threats AuNPs some strategies can improve biocompatibility. studies offer proof principle could potentially alone or combination conventional efficacy.

Language: Английский

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Gold Nanoparticles: Construction for Drug Delivery and Application in Cancer Immunotherapy

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(7), P. 1868 - 1868

Published: July 2, 2023

Cancer immunotherapy is an innovative treatment strategy to enhance the ability of immune system recognize and eliminate cancer cells. However, dose limitations, low response rates, adverse events pose significant challenges. To address these gold nanoparticles (AuNPs) have been explored as immunotherapeutic drug carriers owing their stability, surface versatility, excellent optical properties. This review provides overview advanced synthesis routes for AuNPs utilization improve precision therapies. The also emphasises various aspects AuNP-based immunotherapy, including loading, targeting strategies, release mechanisms. application combined with therapeutic efficacy are briefly discussed. Overall, we aimed provide a recent understanding advances, challenges, prospects anticancer applications.

Language: Английский

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Biomimetic Metallic Nanostructures for Biomedical Applications, Catalysis, and Beyond

Industrial & Engineering Chemistry Research, Journal Year: 2022, Volume and Issue: 61(22), P. 7547 - 7593

Published: May 16, 2022

Nature has inspired scientists to develop green and sustainable nanomaterials with biomimetic functions. Particularly, metallic nanostructures (biometal NPs) unique optical, catalytic, electrical properties have received tremendous attention in many fields, ranging from healthcare agriculture energy environmental sciences. Biometal NPs synthesized by various natural resources such as plant extracts, biomolecules, bacteria, even viruses possess functions including but not limited precise biorecognition, self-assembly, antibacterial/antiviral, enzymatic properties. In this report, we first review the bioinspired synthesis of industrially important metal nanoparticles, followed discussion on how different biological sources affect as-synthesized biometal NPs. Next, recent advancement applications these fields biomedical engineering catalysis, which include development nanobiosensors, imaging probes, nanotherapeutics (e.g., antimicrobial photodynamic/photothermal therapeutic agents), well design multifunctional nanozymes artificial metalloenzymes for chemical biopharmaceutical industries. Finally, highlight some latest advancements nanobiomimicry their emerging clean energy, electronic devices, data storage, shows game-changing role technological near future.

Language: Английский

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Electrochemical biosensors based on polymer nanocomposites for detecting breast cancer: Recent progress and future prospects

Advances in Colloid and Interface Science, Journal Year: 2022, Volume and Issue: 309, P. 102795 - 102795

Published: Oct. 7, 2022

Language: Английский

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Evolution of nanomedicine formulations for targeted delivery and controlled release

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 200, P. 114962 - 114962

Published: June 15, 2023

Language: Английский

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Gold nanoparticles (AuNPs): A versatile material for biosensor application

Talanta Open, Journal Year: 2024, Volume and Issue: 9, P. 100327 - 100327

Published: May 16, 2024

Gold nanoparticles (AuNPs) have become the focus of rapid research due to their unique optical and electronic properties. There has been a noticeable increase in papers relating AuNPs, with over 71,000 publications between 2019 2024. AuNPs possess exceptional stability, low resistance, high conductivity, extensive light interaction, making them well-suited for biological sensing applications. This literature study begins by examining different approaches synthesizing including chemical, physical, methods, before exploring use as biosensors. A comprehensive examination various detection localized surface plasmon resonance (LSPR), luminescence, surface-enhanced Raman scattering (SERS), (SPR), electrochemical properties, is facilitated through an exploration fundamental principles classification We primarily on using medical diagnostics, highlighting current advancements disease AuNPs-based biosensors conditions like COVID-19, dengue fever, diabetes. The review emphasizes achievements synthesis bright prospects biocompatible efficient biosensor

Language: Английский

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Metal-based nanoparticle in cancer treatment: lessons learned and challenges

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: July 11, 2024

Cancer, being one of the deadliest diseases, poses significant challenges despite existence traditional treatment approaches. This has led to a growing demand for innovative pharmaceutical agents that specifically target cancer cells effective treatment. In recent years, use metal nanoparticles (NPs) as promising alternative conventional therapies gained prominence in research. Metal NPs exhibit unique properties hold tremendous potential various applications Studies have demonstrated certain metals possess inherent or acquired anticancer capabilities through their surfaces. These make an attractive focus therapeutic development. this review, we will investigate applicability several distinct classes tumor targeting may include gold, silver, iron oxide, and other with can be exploited purposes. Additionally, provide comprehensive summary risk factors associated application NPs. Understanding addressing these crucial successful clinical translation mitigate any failures NP-based therapies. By exploring identifying factors, review aims contribute advancement strategies. The anticipated outcome is valuable insights pave way targeted utilizing patients.

Language: Английский

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