Nutritional Support for Alcoholic Liver Disease

Nutrients, Journal Year: 2023, Volume and Issue: 15(6), P. 1360 - 1360

Published: March 10, 2023

Malnutrition is a common finding in alcohol use disorders and associated with the prognosis of patients alcoholic liver disease (ALD). These also frequently show deficiencies vitamins trace elements, increasing likelihood anemia altered cognitive status. The etiology malnutrition ALD multifactorial complex includes inadequate dietary intake, abnormal absorption digestion, increased skeletal visceral protein catabolism, interactions between ethanol lipid metabolism. Most nutritional measures derive from general chronic recommendations. Recently, many have been diagnosed metabolic syndrome, which requires individualized treatment via therapy to avoid overnutrition. As progresses cirrhosis, it complicated by protein–energy sarcopenia. Nutritional important management ascites hepatic encephalopathy as failure progresses. purpose review summarize therapies for ALD.

Language: Английский

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The Roles of NFR2-Regulated Oxidative Stress and Mitochondrial Quality Control in Chronic Liver Diseases

Antioxidants, Journal Year: 2023, Volume and Issue: 12(11), P. 1928 - 1928

Published: Oct. 29, 2023

Chronic liver disease (CLD) affects a significant portion of the global population, leading to substantial number deaths each year. Distinct forms like non-alcoholic fatty (NAFLD) and alcoholic (ALD), though they have different etiologies, highlight shared pathologies rooted in oxidative stress. Central metabolism, mitochondria are essential for ATP production, gluconeogenesis, acid oxidation, heme synthesis. However, diseases NAFLD, ALD, fibrosis, mitochondrial function is compromised by inflammatory cytokines, hepatotoxins, metabolic irregularities. This dysfunction, especially electron leakage, exacerbates production reactive oxygen species (ROS), augmenting damage. Amidst this, nuclear factor erythroid 2-related 2 (NRF2) emerges as cellular protector. It not only counters stress regulating antioxidant genes but also maintains health overseeing autophagy biogenesis. The synergy between NRF2 modulation introduces new therapeutic potentials CLD, focusing on preserving integrity against threats. review delves into intricate role shedding light innovative strategies its prevention treatment, through pathways.

Language: Английский

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Fatty Liver Disease, Metabolism and Alcohol Interplay: A Comprehensive Review

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(9), P. 7791 - 7791

Published: April 24, 2023

Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic worldwide, and its incidence has been increasing in recent years because high prevalence obesity metabolic syndrome Western population. Alcohol-related (ArLD) cirrhosis constitutes leading cirrhosis-related deaths worldwide. Both NAFLD ArLD constitute well-known causes damage, with some similarities their pathophysiology. For this reason, they can lead to progression disease, being responsible for a proportion liver-related events deaths. Whether impacts prognosis damage patients still matter debate. Nowadays, synergistic deleterious effect diabetes clearly established heavy alcohol consumption. However, it unknown whether low moderate amounts are good or bad health. The measurement identification possible consumption assessment crucial clinicians, since early intervention, advising abstinence controlling cardiovascular risk factors would improve both comorbidities. This article seeks perform comprehensive review pathophysiology disorders measure impact NAFLD.

Language: Английский

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Inflammatory Response in the Pathogenesis and Treatment of Hepatocellular Carcinoma: A Double-Edged Weapon

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7191 - 7191

Published: June 29, 2024

Hepatocellular carcinoma (HCC) is the most frequent among primary liver tumors (90%) and one of main causes cancer-related death. It develops usually in a chronically inflamed environment, ranging from compensatory parenchymal regeneration to fibrosis cirrhosis: carcinogenesis can potentially happen each these stages. Inflammation determined by chronic viral infection (hepatitis B, hepatitis C, delta viruses) represents an important risk factor for HCC etiology through both direct damage immune-related mechanisms. The deregulation physiological immunological network lead carcinogenesis. recent introduction immunotherapy as gold-standard first-line treatment highlights role immune system inflammation double-edged weapon treatment. In this review we highlight how key hepatocarcinogenesis viral, alcohol metabolic diseases.

Language: Английский

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Interaction between fatty acid oxidation and ethanol metabolism in liver

AJP Gastrointestinal and Liver Physiology, Journal Year: 2024, Volume and Issue: 326(5), P. G483 - G494

Published: March 5, 2024

Fatty acid oxidation (FAO) releases the energy stored in fat to maintain basic biological processes. Dehydrogenation is a major way oxidize fatty acids, which needs NAD

Language: Английский

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Aerobic-Resistance Training with Royal Jelly Supplementation Has a Synergistic Effect on Paraoxonase 1 Changes and Liver Function in Women with MASLD

Medicina, Journal Year: 2025, Volume and Issue: 61(2), P. 349 - 349

Published: Feb. 17, 2025

Background and Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a clinical pathological syndrome characterized by steatosis fat accumulation in parenchymal cells patients without history of excessive alcohol drinking. Currently, there no definitive treatment for MASLD, its prevalence increases with age obesity, after menopause. Among the ways to treat it, we can mention regular sports exercises use natural supplements. Therefore, aim this research investigate compare effects aerobic-resistance training royal jelly supplementation on changes paraoxonase 1, oxidized LDL, function, lipid profile postmenopausal women Dysfunction-Associated Steatotic Liver Disease. Materials Methods: This semi-experimental study involved 23 Disease an average weight (71.34 ± 11.63 kg), (48.54 3.88 years), body mass index (27.63 4.20 kg/m2). They were randomly divided into two groups: exercise + supplement (n = 12) placebo 11). Both groups performed eight-station resistance (8-12 repetitions 2-4 sets) 8 weeks, three sessions per week (for 35-40 min, from 10-15 RPE), then, min active rest, they aerobic intensity 40-85% target heart rate, two-minute intervals 45 s rest. Royal (500 mg days, before each session) was consumed. Blood sampling done 48 h last session. Statistical analysis using variance test repeated measures (two × stages pre-test-post-test) SPSS software (Version 26) significance level p < 0.05. Results: The results statistical show that eight weeks PON1, oxLDL, profiles (HDL, TC, TG), enzymes (ALT, AST) non-alcoholic fatty showed significant difference (p 0.05). increase PON1 0.008) HDL 0.005) group compared group. But decreases oxLDL 0.031), TC 0.045), TG 0.013), LDL 0.027), ALT 0.015) AST 0.009) observed (<0.05). However, 0.015), Conclusions: Based results, it be concluded addition probably efficient recommended strategy minimize harmful affecting activity enzymes, oxidation, profile. Although alone also yielded favorable according findings research, said exercise, combined supplements, may have more positive reducing complications improving function. order obtain accurate scientific evidence, necessary doses timing future studies.

Language: Английский

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Inflammatory liver diseases and susceptibility to sepsis

Clinical Science, Journal Year: 2024, Volume and Issue: 138(7), P. 435 - 487

Published: April 1, 2024

Abstract Patients with inflammatory liver diseases, particularly alcohol-associated disease and metabolic dysfunction-associated fatty (MAFLD), have higher incidence of infections mortality rate due to sepsis. The current focus in the development drugs for MAFLD is resolution non-alcoholic steatohepatitis prevention progression cirrhosis. In patients cirrhosis or alcoholic hepatitis, sepsis a major cause death. As center key immune tissue, guardian, modifier, target Septic dysfunction highest compared other organ dysfunctions. addition maintaining homeostasis, produces secretes hepatokines acute phase proteins (APPs) essential tissue protection, immunomodulation, coagulation. Inflammatory diseases profound disorder impairment energy metabolism, regeneration, production/secretion APPs hepatokines. Herein, author reviews roles (1) disorders metabolism glucose, acids, ketone bodies, amino acids as well clearance ammonia lactate pathogenesis sepsis; (2) cytokines/chemokines (3) protection against injury infections; (4) nuclear receptors/signaling pathways underlying injuries drug targets Approaches that on regeneration will not only treat but also prevent severe

Language: Английский

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Candida tropicalis, Clavispora lusitaniae, Limosilactobacillus fermentum, Liquorilactobacillus mali, and Leuconostoc pseudomesenteroides are associated with Ethanol Levels in Malian Traditional Fermented Milk Products

Microbial Pathogenesis, Journal Year: 2025, Volume and Issue: unknown, P. 107298 - 107298

Published: Jan. 1, 2025

Language: Английский

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The Relationship Between Serum Biochemical Variables and Corneal Biomechanics Measured by Corvis ST Among Healthy Young Adults

Translational Vision Science & Technology, Journal Year: 2025, Volume and Issue: 14(2), P. 19 - 19

Published: Feb. 14, 2025

To investigate the relationship between serum biochemical variables and corneal biomechanics in healthy young adults. A total of 1645 university students were included. Every student underwent an ophthalmologic examination by Corvis ST to measure a blood evaluate alanine aminotransferase (ALT), aspartate (AST), urea, creatinine, uric acid (UA) levels. Canonical correlation analysis (CCA) was conducted assess their relationship. significant found both men women. For men, canonical identified association time first applanation (A1t), second (A2t), highest concavity (HC-t), deflection amplitude (HC-DeflA), biomechanically corrected intraocular pressure (bIOP) with ALT, AST, UA (r = 0.235, P 0.03). women, A1t, A2t, bIOP ALT 0.187, < 0.01). Elevated levels associated softer corneas greater elasticity viscidity. The study provides novel evidence for ocular changes. These findings may help clinicians perform adequate preoperative evaluations when performing surgery on patients liver or kidney disorders, as well helping public health practitioners understand changes people.

Language: Английский

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Machine learning models and AI in predicting diagnosis and prognosis in alcohol-related and metabolic dysfunction-associated steatotic liver disease

Metabolism and Target Organ Damage, Journal Year: 2025, Volume and Issue: 5(1)

Published: Feb. 25, 2025

Steatotic liver disease (SLD) is the most common cause of globally, with an ever-increasing burden. The two primary components SLD are metabolic dysfunction-associated steatotic (MASLD) and Alcohol-Associated Liver Disease (ALD). Both entities have important knowledge gaps in differentiation, diagnosis, risk stratification, prognosis. Given enormous burden both MASLD ALD their diverse presentation, they form ideal ground for application artificial intelligence (AI) machine learning (ML) techniques algorithms. ML models can aid prediction among large populations estimate those at highest progression or mortality, while applications AI technology better detection monitored treatment approaches. use digital pathology therapeutics attractive options moving toward personalized medicine. This review briefly summarizes emerging literature on technologies across domains detection,

Language: Английский

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