Mechanisms of Ageing and Development, Journal Year: 2024, Volume and Issue: 220, P. 111952 - 111952
Published: June 4, 2024
Language: Английский
Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(14), P. 3992 - 3992
Published: July 9, 2024
Background: Psoriasis is an immune-mediated chronic disorder associated with various comorbidities. Even though biologics and small-molecule inhibitors are the mainstay treatment for moderate-to-severe psoriasis, there no current consensus regarding which agent should be used a specific type of patient. This paper aims to test reliability blood-count-derived inflammatory markers in assessing response psoriasis. Material Methods: Bio-naïve adult patients diagnosed plaque psoriasis fulfilling inclusion criteria were enrolled. They divided into study subgroups based on choice, analyzed at baseline, three-month, six-month, twelve-month visits. Results: A total 240 included. The highest number underwent ixekizumab. neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), platelet-to-monocyte (PMR), monocyte-to-lymphocyte (MLR), derived (d-NLR), systemic inflammation index (SIRI), immune (SII), aggregate (AISI) all varied significantly (p < 0.005) between four area severity (PASI) score correlated PLR, d-NLR, SII, while scalp (PSSI) AISI SIRI. More than half reached target goal PASI90 six-month visit. 77 super-responders, undergoing Higher baseline values d-NLR SIRI independent predictors super-responder status. Conclusions: Blood-count-derived can serve as indicators super-responders our study.
Language: Английский
Citations
5
Diabetology & Metabolic Syndrome, Journal Year: 2025, Volume and Issue: 17(1)
Published: March 24, 2025
Abstract Background This study intends to examine any possible correlation between monocyte-to-lymphocyte ratio (MLR) and cardiovascular diseases (CVD). Methods Data from the 1999–2020 National Health Nutrition Examination Survey (NHANES) in USA were analyzed. Heart attacks, angina pectoris, congestive heart failure (CHF), coronary disease (CHD), stroke all covered by CVD. The independent relationships these events MLR levels, as well other inflammatory indices (system inflammation response index (SIRI), aggregate of systemic (AISI), C-reactive protein-to-albumin (CAR)), investigated. Furthermore, interaction tests subgroup analysis performed. Diagnostic capacities also predicted compared using receiver operating characteristic (ROC) curves. Results Males made up 49.63% 46,289 people who recruited this study. prevalence CVD its follows: CHF at 2.99%, CHD 3.72%, pectoris 2.57%, attacks 3.94%, 3.48%, with itself 7.98%. positively correlated. Specifically, smooth curve fittings found a non-linear relationship Moreover, higher levels linked increased rates CHF, CHD, strokes. SIRI wa s have positive outperformed (SIRI, AISI, CAR) terms discriminative capacity accuracy predicting CVD, attack, stroke, according ROC analysis. Conclusions Compared indicators CAR), appears be better for stroke. American adults elevated should aware harm caused Causal inference is, however, limited cross-sectional design dependence on self-reported data. Further longitudinal studies are needed validate findings.
Language: Английский
Citations
0
American Journal of Translational Research, Journal Year: 2024, Volume and Issue: 16(7), P. 2940 - 2952
Published: Jan. 1, 2024
To analyze the predictive value of lipoprotein-associated phospholipase A2 (Lp-PLA2), N-terminal prohormone brain natriuretic peptide (NT-proBNP), and peripheral blood-related ratios at initial diagnosis for heart failure (HF) after early-onset infarction in patients with acute myocardial (AMI).
Language: Английский
Citations
2
Advances in Clinical Medicine, Journal Year: 2024, Volume and Issue: 14(04), P. 2526 - 2532
Published: Jan. 1, 2024
Language: Английский
Citations
0
Mechanisms of Ageing and Development, Journal Year: 2024, Volume and Issue: 220, P. 111952 - 111952
Published: June 4, 2024
Language: Английский
Citations
0