Harnessing fungal endophytes for natural management: a biocontrol perspective

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: Dec. 8, 2023

In the ever-evolving realm of agriculture, convoluted interaction between plants and microorganisms have assumed paramount significance. Fungal endophytes, once perceived as mere bystanders within plant tissues, now emerged dynamic defenders health. This comprehensive review delves into captivating world fungal endophytes their multifaceted biocontrol mechanisms. Exploring unique ability to coexist with hosts, unlocked a treasure trove biological weaponry fend off pathogens enhance resilience. From synthesis bioactive secondary metabolites intricate signaling pathways these silent allies are masters warfare. The is quite fascinating they engage in delicate dance immune system, orchestrating symphony defense that challenges traditional notions plant-pathogen interactions. journey through various mechanisms employed by enigmatic combat diseases, will lead revelational understanding sustainable agriculture. cutting-edge research promising prospects, shedding light on how hold key reduction chemical inputs Their ecological significance, potential for bioprospecting avenues future also explored. exploration promise not only enrich our comprehension plant-microbe relationships but also, shape ecofriendly agricultural practices. this web life, indeed unsung heroes, silently guarding crops illuminating path towards greener, healthier tomorrow.

Language: Английский

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Bioactive Compounds Produced by Endophytic Microorganisms Associated with Bryophytes—The “Bryendophytes”

Molecules, Journal Year: 2023, Volume and Issue: 28(7), P. 3246 - 3246

Published: April 5, 2023

The mutualistic coexistence between the host and endophyte is diverse complex, including growth regulation, exchange of substances like nutrients or biostimulants, protection from microbial herbivore attack. latter commonly associated with production by endophytes bioactive natural products, which also possess multiple activities, antibacterial, insecticidal, antioxidant, antitumor, antidiabetic properties, making them interesting valuable model for future development into drugs. higher plants have been extensively studied, but there a dearth information on biodiversity endophytic microorganisms bryophytes and, more importantly, their metabolites. For first time, we name bryophyte “bryendophytes” to elaborate this important productive source biota. In review, summarize current knowledge diversity compounds produced endophytes, emphasizing molecules bryendophytes. Moreover, isolation methods bryendophytes mosses, liverworts, hornworts are described.

Language: Английский

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Antimicrobials from endophytes as novel therapeutics to counter drug-resistant pathogens

Critical Reviews in Biotechnology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 27

Published: May 6, 2024

The rapid increase in antimicrobial resistance (AMR) projects a "global emergency" and necessitates need to discover alternative resources for combating drug-resistant pathogens or "superbugs." One of the key themes "One Health Concept" is based on fact that interconnected network humans, environment, animal habitats majorly contribute selection spread AMR. Moreover, injudicious overuse antibiotics healthcare, associated disciplines, further aggravates concern. prevalence persistence AMR global economic burden are constantly witnessing an upsurge due fewer therapeutic options, rising mortality statistics, expensive healthcare. present decade has witnessed extensive exploration utilization bio-based harnessing potential efficacies. discovery characterization diverse chemical entities from endophytes as potent antimicrobials define important yet less-explored area natural product-mediated drug discovery. Endophytes-produced show efficacies targeting microbial synthetic biology (SB) mediated engineering yield enhancement, forms prospective research. In keeping with urgent requirements new/novel growing concerns about pathogenic microbes AMR, this paper comprehensively reviews emerging trends, prospects, challenges their effective production via SB. This literature review would serve platform novel bioactive biological organisms "novel therapeutics" address

Language: Английский

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Fungal Endophytes and Soilborne Fungi

Published: Jan. 1, 2025

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Biological Control Mechanism of Endophytic Fungi

Published: Jan. 1, 2025

Language: Английский

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Biosynthesis of Copper Nanoparticles from Endophytic Fungi and Their Role in Plant Disease Management

Published: Jan. 1, 2025

Language: Английский

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Antimicrobial potential of endophytic fungal compounds: Fighting drug resistance

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 133 - 145

Published: Jan. 1, 2025

Language: Английский

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Antimicrobial and Cytotoxic Activities of the Secondary Metabolites of Endophytic Fungi Isolated from the Medicinal Plant Hyssopus officinalis

Antibiotics, Journal Year: 2023, Volume and Issue: 12(7), P. 1201 - 1201

Published: July 18, 2023

According to the World Health Organization, it is estimated that by 2050, drug-resistant infections could cause up 10 million deaths annually. Therefore, finding a new generation of antibiotics crucial. Natural compounds from endophytic fungi are considered potential source new-generation antibiotics. The antimicrobial and cytotoxic effects ethyl acetate extracts nine fungal isolates obtained Hyssopus officinalis were investigated for bioassay-guided isolation natural compounds. An extract isolate VII showed highest activities against Gram-positive bacteria Bacillus subtilis Staphylococcus aureus (30.12 ± 0.20 mm 35.21 mm) Gram-negative Escherichia coli Pseudomonas aeruginosa (30.41 0.23 25.12 0.25 among tested isolates. Molecular identification confirmed as Chaetomium elatum based on sequencing its ITS genes, was discovered this first time C. had been isolated H. officinalis. This cultured at large scale active compound. Penicillic acid chemical structure established NMR spectroscopy. penicillic strong antibacterial with 20.68 25.51 inhibition zones, respectively. In addition, MIC MBC values antibiofilm determined. It found reduced level biofilms in proportion activity.

Language: Английский

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The Potential of Endophytic Fungi for Enhancing the Growth and Accumulation of Phenolic Compounds and Anthocyanin in Maled Phai Rice (Oryza sativa L.)

Journal of Fungi, Journal Year: 2023, Volume and Issue: 9(9), P. 937 - 937

Published: Sept. 16, 2023

Rice (Oryza sativa L.) is one of the most popular cereal crops, being consumed by almost half world’s population. Among several cultivars widely distributed in Thailand, Maled Phai a Thai pigmented-upland rice with exceptionally high nutritional value and demand local market. This study aimed to investigate feasibility producing plant growth-promoting properties (PGP) enhancing accumulation phytochemicals seeds endophytic fungi isolated from upland black rice. total 56 isolates, 4 effective PGP isolates were identified as Trichoderma zelobreve PBMP16, Talaromyces pinophilus PBMP28, Aspergillus flavus KKMP34, sp. PBMP4 based on their morphological characteristics multigene (ITS, rpb2, tef-1, CaM, BenA) phylogenetic analyses. These four could promote growth parameters under greenhouse conditions. Outstandingly, inoculated Tr. PBMP16 had significant increase seed weight, root length, phenolic compounds, anthocyanin, antioxidants, N uptake, which higher than those noninoculated control, even better chemical fertilizer. Overall, this report shows that efficiently promoted increased antioxidants

Language: Английский

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Antioxidant and Antibacterial Activity of Endophytic Fungi Isolated from Fruit of Sungkai (Peronema canescens)

Science & Technology Indonesia, Journal Year: 2024, Volume and Issue: 9(1), P. 17 - 27

Published: Jan. 22, 2024

Peronema canescens, often known as sungkai, is widely used and can be found all around Indonesia. The public believes that the leaves may reduce fever strengthen immune system. However, effectiveness of sungkai fruit has not been thoroughly investigated. In this research, we looked at endophytic fungus extracts from fruit’s have antioxidant antibacterial properties. study’s results will serve foundation for further investigation into development potential natural chemicals with Morphologically, fungi isolated were identified. properties fungal studied using DPPH technique paper disk diffusion method. By employing molecular identification column chromatography to separate active compounds, most likely isolates based on bioactivity tests. Using 1D NMR spectroscopic methods, chemical’s structure was determined, compared data same compound published in literature. Fruit had 8 strains (RBH1-RBH8). Strong very strong activity shown by RBH5 isolate (IC50 < 20 μg/mL). Pythium periplocum determined testing. Pure chemical extracted highly potent effects. identified spectroscopy 3-hydroxy-4(hydroxy(4-hydroxyphenyl)methyl)-γ-butyrolactone. study developing compounds pharmaceutical raw materials via research phases.

Language: Английский

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