Thiosemicarbazone-Based Compounds: Cancer Cell Inhibitors with Antioxidant Properties DOI Creative Commons
Olga Garbuz, Emil Ceban, Dorin Istrati

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(9), P. 2077 - 2077

Published: May 7, 2025

Thiosemicarbazone-based compounds have attracted significant attention in recent years due to their potential as inhibitors of cancer cell proliferation. They not only exhibit strong antiproliferative effects but also possess antioxidant properties that are crucial combating oxidative stress linked progression. This review highlights specific significantly higher activities demonstrate lower toxicity compared traditional chemotherapy agents. is important because it suggests these could provide better treatment options while reducing the side often associated with chemotherapy. A detailed analysis structure–activity relationships (SARs) reveals unique structural features play a role enhanced effectiveness. Understanding which molecular characteristics contribute improved activity will be key for future compound design. The findings from this study emphasize need further exploration and development novel By investigating biological mechanisms optimizing structures, researchers can improve strategies, providing safer more effective patients. Despite substantial previous research on thiosemicarbazones isothiosemicarbazones, field still holds many unknowns opportunities discovery. Studying coordination chemistry 3d metal ions strategically modifying inner structures may lead new promising selectivity. Overall, exploring isothiosemicarbazones innovative pharmacological agents against unlock full potential, enhancing protocols improving patient survival rates.

Language: Английский

Thiosemicarbazone-Based Compounds: Cancer Cell Inhibitors with Antioxidant Properties DOI Creative Commons
Olga Garbuz, Emil Ceban, Dorin Istrati

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(9), P. 2077 - 2077

Published: May 7, 2025

Thiosemicarbazone-based compounds have attracted significant attention in recent years due to their potential as inhibitors of cancer cell proliferation. They not only exhibit strong antiproliferative effects but also possess antioxidant properties that are crucial combating oxidative stress linked progression. This review highlights specific significantly higher activities demonstrate lower toxicity compared traditional chemotherapy agents. is important because it suggests these could provide better treatment options while reducing the side often associated with chemotherapy. A detailed analysis structure–activity relationships (SARs) reveals unique structural features play a role enhanced effectiveness. Understanding which molecular characteristics contribute improved activity will be key for future compound design. The findings from this study emphasize need further exploration and development novel By investigating biological mechanisms optimizing structures, researchers can improve strategies, providing safer more effective patients. Despite substantial previous research on thiosemicarbazones isothiosemicarbazones, field still holds many unknowns opportunities discovery. Studying coordination chemistry 3d metal ions strategically modifying inner structures may lead new promising selectivity. Overall, exploring isothiosemicarbazones innovative pharmacological agents against unlock full potential, enhancing protocols improving patient survival rates.

Language: Английский

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