Oxidative Medicine and Cellular Longevity,
Journal Year:
2020,
Volume and Issue:
2020, P. 1 - 13
Published: Dec. 21, 2020
The
phenomenon
of
oxidative
stress,
characterized
as
an
imbalance
in
the
production
reactive
oxygen
species
and
antioxidant
responses,
is
a
well-known
inflammatory
mechanism
constitutes
important
cellular
process.
relationship
viral
infections,
production,
antiviral
response
relevant.
Therefore,
aim
this
review
to
report
studies
showing
how
may
positively
or
negatively
affect
pathophysiology
infection.
We
focus
on
known
respiratory
especially
severe
acute
syndrome
coronaviruses
(SARS-CoVs),
attempt
provide
information
challenges
posed
by
current
COVID-19
pandemic.
Because
therapies
for
(e.g.,
SARS-CoV-2)
are
rare,
knowledge
about
relevant
compounds
pathways
be
understanding
pathogenesis
identifying
possible
therapeutic
targets.
PLoS ONE,
Journal Year:
2022,
Volume and Issue:
17(7), P. e0268396 - e0268396
Published: July 6, 2022
To
assess
the
evidence
on
SARS-CoV2
infection
and
Covid-19
in
relation
to
deficiency
supplementation
of
vitamin
D,
we
conducted
a
systematic
review
up
April
2021.
We
summarised
data
from
38
eligible
studies,
which
presented
risk
estimates
for
at
least
one
endpoint,
including
two
RCT
27
cohort-studies:
205565
patients
with
information
25OHD
status
2022
taking
D
total
1197
admitted
ICU
or
who
needed
invasive
mechanical
ventilation
intubation
hospital
stay,
more
than
910
deaths.
Primary
outcomes
were
severity
mortality
main
aim
was
evaluate
association
supplementation.
Random
effects
models
showed
that
associated
significant
lower
both
severe
disease
(SRR
0.38,
95%
CI
0.20-0.72,
6
studies)
0.35,
0.17-0.70,
8
studies).
There
no
statistically
dose
differences
between
studies:
summary
regular
doses
remain
significant,
suggesting
higher
are
not
necessary.
For
supplementation,
greater
reduction
emerged
older
individuals
latitudes.
Regarding
quality
assessed
using
New
Castle-Ottawa
scale,
analysis
revealed
most
cases
low,
medium
high
studies.
found
associations
Covid-19,
encompassing
risks
worsening
mortality,
especially
seasons
characterized
by
patients.
Dedicated
randomized
clinical
studies
encouraged
confirm
these
results.
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(15), P. 3320 - 3320
Published: July 26, 2023
Over
the
last
20
years,
use
of
dietary
supplements
(DS)
has
continued
to
grow
in
many
countries.
Due
public
health
crisis
brought
on
by
COVID-19
pandemic
and
amidst
fears
regarding
vaccines
their
low
supply
regions
world,
there
been
a
marked
interest
DS
as
alternative
means
protecting
against
treating
this
emerging
disease,
well
boosting
immune
system
minimizing
risk
inflammation.
Despite
lack
evidence
suggest
efficacy,
surge
sales
reported
parts
world.
Questions
have
also
raised
about
effects
associated
with
due
increased
during
crisis.
Numerous
scientific
studies
demonstrated
beneficial
properties
some
adverse
even
toxic
effects.
In
addition,
given
current
global
issue,
review
is
needed
establish
status
before
The
aim
summarize
impact
incidence
pandemic,
regulation
market
trends.
First,
we
provide
an
overview
DS,
including
comprehensive
legislative
regulatory
aspects
USA,
China,
EU,
Algeria.
Second,
describe
prevalence
most
commonly
consumed
efficacy
prophylactic
modality
era
COVID-19.
Additionally,
examine
structure
size
countries
that
predominantly
produce
import
them,
its
trend,
growth.
Finally,
review,
discuss
profile
users.
Nutrients,
Journal Year:
2021,
Volume and Issue:
13(5), P. 1714 - 1714
Published: May 19, 2021
Insufficient
blood
levels
of
the
neurohormone
vitamin
D
are
associated
with
increased
risk
COVID-19
severity
and
mortality.
Despite
global
rollout
vaccinations
promising
preliminary
results,
focus
remains
on
additional
preventive
measures
to
manage
COVID-19.
Results
conflict
D's
plausible
role
in
preventing
treating
We
examined
relation
between
status
mortality
among
multiethnic
population
United
Arab
Emirates.
Our
observational
study
used
data
for
522
participants
who
tested
positive
SARS-CoV-2
at
one
main
hospitals
Abu
Dhabi
Dubai.
Only
464
those
patients
were
included
analysis.
Demographic
clinical
retrospectively
analyzed.
Serum
samples
immediately
drawn
first
hospital
visit
measure
serum
25-hydroxyvitamin
[25(OH)D]
concentrations
through
automated
electrochemiluminescence.
Levels
<
12
ng/mL
significantly
higher
severe
infection
death.
Age
was
only
other
independent
factor,
whereas
comorbidities
smoking
did
not
contribute
outcomes
upon
adjustment.
Sex
an
important
predictor
or
is
conducted
UAE
25(OH)D
SARS-CoV-2-positive
confirm
association
International Journal of Clinical Practice,
Journal Year:
2021,
Volume and Issue:
75(11)
Published: July 29, 2021
Evidence
recommends
that
vitamin
D
might
be
a
crucial
supportive
agent
for
the
immune
system,
mainly
in
cytokine
response
regulation
against
COVID-19.
Hence,
we
carried
out
systematic
review
and
meta-analysis
order
to
maximise
use
of
everything
exists
about
role
Nutrients,
Journal Year:
2021,
Volume and Issue:
13(10), P. 3596 - 3596
Published: Oct. 14, 2021
Much
research
shows
that
blood
calcidiol
(25(OH)D3)
levels
correlate
strongly
with
SARS-CoV-2
infection
severity.
There
is
open
discussion
regarding
whether
low
D3
caused
by
the
or
if
deficiency
negatively
affects
immune
defense.
The
aim
of
this
study
was
to
collect
further
evidence
on
topic.
Nutrients,
Journal Year:
2022,
Volume and Issue:
14(8), P. 1625 - 1625
Published: April 13, 2022
Coronavirus
disease
2019
(COVID-19)
has
quickly
become
a
global
pandemic.
Reports
from
different
parts
of
the
world
indicate
that
significant
proportion
people
who
have
recovered
COVID-19
are
suffering
various
health
problems
collectively
referred
to
as
"long
COVID-19".
Common
symptoms
include
fatigue,
shortness
breath,
cough,
joint
pain,
chest
muscle
aches,
headaches,
and
so
on.
Vitamin
D
is
an
immunomodulatory
hormone
with
proven
efficacy
against
upper
respiratory
tract
infections.
can
inhibit
hyperinflammatory
reactions
accelerate
healing
process
in
affected
areas,
especially
lung
tissue.
Moreover,
vitamin
deficiency
been
associated
severity
mortality
cases,
high
prevalence
hypovitaminosis
found
patients
acute
failure.
Thus,
there
promising
reasons
promote
research
into
effects
supplementation
patients.
However,
no
studies
date
affects
post-COVID-19
or
biomarkers.
Based
on
this
scenario,
review
aims
provide
up-to-date
overview
potential
role
long
current
literature
topic.
QJM,
Journal Year:
2022,
Volume and Issue:
115(10), P. 665 - 672
Published: Feb. 9, 2022
The
evidence
regarding
the
efficacy
of
vitamin
D
supplementation
in
reducing
severity
COVID-19
is
still
insufficient.
This
partially
due
to
lack
primary
robust
trial-based
data
and
heterogeneous
study
designs.
International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
22(10), P. 5251 - 5251
Published: May 16, 2021
Coronavirus
disease
2019
(COVID-19),
caused
by
severe
acute
respiratory
syndrome
coronavirus-2
(SARS-CoV-2)
is
still
an
ongoing
global
health
crisis.
Immediately
after
the
inhalation
of
SARS-CoV-2
viral
particles,
alveolar
type
II
epithelial
cells
harbor
and
initiate
local
innate
immunity.
These
particles
can
infect
circulating
macrophages,
which
then
present
coronavirus
antigens
to
T
cells.
Subsequently,
activation
differentiation
various
types
cells,
as
well
uncontrollable
cytokine
release
(also
known
storms),
result
in
tissue
destruction
amplification
immune
response.
Vitamin
D
enhances
immunity
required
for
combating
COVID-19
activating
toll-like
receptor
2.
It
also
antimicrobial
peptide
synthesis,
such
through
promotion
expression
secretion
cathelicidin
β-defensin;
promotes
autophagy
autophagosome
formation;
increases
synthesis
lysosomal
degradation
enzymes
within
macrophages.
Regarding
adaptive
immunity,
vitamin
CD4
Journal of the American Nutrition Association,
Journal Year:
2021,
Volume and Issue:
41(3), P. 250 - 265
Published: Feb. 18, 2021
Objective
Preliminary
findings
suggest
a
relationship
between
lower
serum
25-hydroxyvitamin
D
[25(OH)D]
levels
and
incidence
severity
of
COVID-19.
The
aim
this
study
was
to
evaluate
the
vitamin
status
at
admission
different
markers
inflammation,
coagulation,
sepsis
in
hospitalized
patients
with
International Journal of General Medicine,
Journal Year:
2022,
Volume and Issue:
Volume 15, P. 343 - 352
Published: Jan. 1, 2022
The
world
is
experiencing
a
life-altering
and
extraordinary
situation
in
response
to
the
COVID-19
pandemic.
There
are
limited
data
controversies
regarding
relationship
between
vitamin
D
(Vit
D)
status
disease.
Thus,
this
study
was
designed
investigate
association
Vit
levels
severity
or
outcomes
of
