Effects of a Multicomponent Mycotoxin Detoxifying Agent on Health and Performance of Weaned Pigs Under Combined Dietary Exposure to Deoxynivalenol (DON) and Zearalenone (ZEN) DOI Creative Commons
Jog Raj, Panagiotis Tassis,

K. Männer

et al.

Toxins, Journal Year: 2025, Volume and Issue: 17(3), P. 146 - 146

Published: March 19, 2025

The aim of the present study was to evaluate efficacy a multicomponent mycotoxin detoxifying agent (MMDA, MYCORAID, Patent Co, Mišićevo, Serbia) in weaned pigs receiving contaminated feed with deoxynivalenol (DON) and zearalenone (ZEN). In total, 168 were equally allocated four experimental groups from day 25 66 age. T1 group received without mycotoxins or MMDA. T2 (CF) 1.5 mg DON/kg 0.9 ZEN/kg for first two weeks 1.2 rest trial period, addition Groups T3 T4 CF g MMDA/kg (T3), 3 (T4). Performance parameters, stress, inflammatory biomarkers, as well residues liver, kidney, muscle tissue assessed. results demonstrated improved average daily gain (ADG) conversion ratio (FCR) along reduced DON kidney samples when compared group. Although typical dose–response relationship not all parameter alterations, proved test product growth performance absorption under concurrent ZEN exposure conditions supported its use mitigating tool against mycotoxicosis field conditions.

Language: Английский

Unlocking the Potential of Bacillus subtilis: A Comprehensive Study on Mycotoxin Decontamination, Mechanistic Insights, and Efficacy Assessment in a Liquid Food Model DOI Creative Commons
Donato Greco, Vito D’Ascanio, Elisa Santovito

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(3), P. 360 - 360

Published: Jan. 22, 2025

Mycotoxin detoxification by microorganisms offers a specific, economical, and environmentally sustainable alternative to physical/chemical methods. Three strains of B. subtilis, isolated from poultry farm environments recognized EFSA as safe in animal nutrition for all species, consumers, the environment, were screened their ability remove mycotoxins. All them demonstrated mycotoxin-dependent removal efficacy, being very effective against ZEA its analogues (α- β-ZOL, α- β-ZAL, ZAL) achieving up 100% within 24 h under aerobic, anaerobic, restrictive growth conditions with toxins sole carbon source. remained across wide range pH values (5–8), temperatures (20–40 °C), at high toxin concentrations (up 10 µg/mL). Additionally, 87% was achieved after 48 incubation (30 °C) contaminated liquid food model containing 1 µg/mL toxin. Mechanistic studies suggest that involves metabolic processes rather than physical adsorption or entrapment into bacterial cells. Enzymatic activities cells associated cell walls likely play role metabolization Interestingly, it has been observed culture media can influence and/or conjugation toxin, which result production various metabolites. Further investigation is needed identify these metabolites assess safety.

Language: Английский

Citations

0
The Role of Quorum Sensing Effector Coma in Regulating Biofilm Formation and Surfactin Production in Bacillus Subtilis Asag 010 DOI
Ru Jia, Yu Wang,

Huachao Wang

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Smart Probiotic Solutions for Mycotoxin Mitigation: Innovations in Food Safety and Sustainable Agriculture DOI
Alice Njolke Mafe,

I. H. Nkene,

Ali B. M. Ali

et al.

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: May 2, 2025

Language: Английский

Citations

0
Effects of a Multicomponent Mycotoxin Detoxifying Agent on Health and Performance of Weaned Pigs Under Combined Dietary Exposure to Deoxynivalenol (DON) and Zearalenone (ZEN) DOI Creative Commons
Jog Raj, Panagiotis Tassis,

K. Männer

et al.

Toxins, Journal Year: 2025, Volume and Issue: 17(3), P. 146 - 146

Published: March 19, 2025

The aim of the present study was to evaluate efficacy a multicomponent mycotoxin detoxifying agent (MMDA, MYCORAID, Patent Co, Mišićevo, Serbia) in weaned pigs receiving contaminated feed with deoxynivalenol (DON) and zearalenone (ZEN). In total, 168 were equally allocated four experimental groups from day 25 66 age. T1 group received without mycotoxins or MMDA. T2 (CF) 1.5 mg DON/kg 0.9 ZEN/kg for first two weeks 1.2 rest trial period, addition Groups T3 T4 CF g MMDA/kg (T3), 3 (T4). Performance parameters, stress, inflammatory biomarkers, as well residues liver, kidney, muscle tissue assessed. results demonstrated improved average daily gain (ADG) conversion ratio (FCR) along reduced DON kidney samples when compared group. Although typical dose–response relationship not all parameter alterations, proved test product growth performance absorption under concurrent ZEN exposure conditions supported its use mitigating tool against mycotoxicosis field conditions.

Language: Английский

Citations

0