Tailoring Carrier-Free Nanoparticles based on Natural Small Molecule Assembly for Synergistic Anti-tumor Efficacy DOI Creative Commons
Di Wu, Bin Zhou, Ying Liu

et al.

Asian Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: unknown, P. 100992 - 100992

Published: Nov. 1, 2024

Interfacial modular assemblies of versatile polyphenols have attracted widespread interest in surface and materials engineering. In this study, natural polyphenol (tannic acid, TA) nobiletin (NOB) can directly form binary carrier-free spherical nanoparticles (NT NPs) through synergistically driven by a variety interactions (such as hydrogen bonding, oxidative reactions, etc.). The synthesis involves polyphenolic deposition on hydrophobic NOB nanoaggregates, followed situ self-polymerization. Interestingly, the assembled NT NPs exhibit controllable dynamic changes particle size during initial stage. Ultimately, uniform appear stable, with high loading capability, enabling incorporated to preserve their function. Furthermore, vitro evaluations demonstrate that rational combination module induce apoptosis inhibit tumor metastasis for both lung cancer H1299 human fibrosarcoma HT1080 cell lines. Notably, optimized NT48 were then verified vivo experiments achieve promising synergistic anti-tumor efficacy. These findings not only provide new opportunities streamlined sensible engineering future polyphenol-based biomaterials, but also open up prospects design small-molecule nature phytochemicals.

Language: Английский

Drug screening approaches for small-molecule compounds in cancer-targeted therapy DOI
Yelin Zhao,

Chengfu Yuan,

Yuchen Shi

et al.

Journal of drug targeting, Journal Year: 2024, Volume and Issue: 33(3), P. 368 - 383

Published: Nov. 22, 2024

Small-molecule compounds exhibit distinct pharmacological properties and clinical effectiveness. Over the past decade, advances in covalent drug discovery have led to successful small-molecule drugs, such as EGFR, BTK, KRAS (G12C) inhibitors, for cancer therapy. Researchers are paying more attention refining screening methods aiming high throughput, fast speed, specificity, accuracy. Therefore, development of drugs has been facilitated by significantly reducing time financial resources, increasing promising lead compared with traditional methods. This review aims introduce classical emerging targeted It includes classification, principles, advantages, disadvantages, applications, serving valuable references subsequent researchers.

Language: Английский

Citations

0
Effect of combination of polyphenols, polysaccharide, and sodium selenite on bortezomib anti-cancer action DOI
Sarita Rani, Shruti Gupta,

Kiran Kumar Tejavath

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 138809 - 138809

Published: Dec. 1, 2024

Language: Английский

Citations

0
Tailoring Carrier-Free Nanoparticles based on Natural Small Molecule Assembly for Synergistic Anti-tumor Efficacy DOI Creative Commons
Di Wu, Bin Zhou, Ying Liu

et al.

Asian Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: unknown, P. 100992 - 100992

Published: Nov. 1, 2024

Interfacial modular assemblies of versatile polyphenols have attracted widespread interest in surface and materials engineering. In this study, natural polyphenol (tannic acid, TA) nobiletin (NOB) can directly form binary carrier-free spherical nanoparticles (NT NPs) through synergistically driven by a variety interactions (such as hydrogen bonding, oxidative reactions, etc.). The synthesis involves polyphenolic deposition on hydrophobic NOB nanoaggregates, followed situ self-polymerization. Interestingly, the assembled NT NPs exhibit controllable dynamic changes particle size during initial stage. Ultimately, uniform appear stable, with high loading capability, enabling incorporated to preserve their function. Furthermore, vitro evaluations demonstrate that rational combination module induce apoptosis inhibit tumor metastasis for both lung cancer H1299 human fibrosarcoma HT1080 cell lines. Notably, optimized NT48 were then verified vivo experiments achieve promising synergistic anti-tumor efficacy. These findings not only provide new opportunities streamlined sensible engineering future polyphenol-based biomaterials, but also open up prospects design small-molecule nature phytochemicals.

Language: Английский

Citations

0