Setting your clock: associations between timing of objective physical activity and cardiovascular disease risk in the general population

European Journal of Preventive Cardiology, Journal Year: 2022, Volume and Issue: 30(3), P. 232 - 240

Published: Nov. 14, 2022

Abstract Aims Little is known about the impact of daily physical activity timing (here referred to as ‘chronoactivity’) on cardiovascular disease (CVD) risk. We aimed examined associations between chronoactivity and multiple CVD outcomes in UK Biobank. Methods results data were collected UK-Biobank through triaxial accelerometer over a 7-day measurement period. used K-means clustering create clusters participants with similar irrespective mean intensity activity. Multivariable-adjusted Cox-proportional hazard models estimate ratios (HRs) comparing different adjusted for age sex (model 1), baseline risk factors 2). Additional stratified analyses done by sex, level, self-reported sleep chronotype. included 86 657 individuals (58% female, age: 61.6 [SD: 7.8] years, BMI: 26.6 [4.5] kg/m2). Over follow-up period 6 3707 incident events reported. Overall, tendency late morning had lower coronary artery (HR: 0.84, 95%CI: 0.77, 0.92) stroke 0.83, 0.70, 0.98) compared midday pattern These effects more pronounced women (P-value interaction = 0.001). did not find evidence favouring effect modification total level Conclusion Irrespective activity, was associated risks diseases, highlighting potential importance prevention.

Language: Английский

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Circadian Rest–Activity Rhythms, Delirium Risk, and Progression to Dementia

Annals of Neurology, Journal Year: 2023, Volume and Issue: 93(6), P. 1145 - 1157

Published: Feb. 21, 2023

Objective Delirium is a complex neurocognitive syndrome suspected to be bidirectionally linked dementia. Circadian rhythm disturbances likely contribute dementia pathogenesis, but whether these are related delirium risk and progression all‐cause unknown. Methods We analyzed continuous actigraphy data from 53,417 middle‐aged or older UK Biobank participants during median 5 years of follow‐up. Four measures were used characterize the 24‐hour daily rest–activity rhythms (RARs): normalized amplitude, acrophase representing peak activity time, interdaily stability, intradaily variability (IV) for fragmentation rhythm. Cox proportional hazards models examined RARs predicted incident (n = 551) 61). Results Suppressed lowest (Q1) versus highest (Q4) quartile (hazard ratio [HR] Q1 vs Q4 1.94, 95% confidence interval [CI] 1.53–2.46, p < 0.001), more fragmented (higher IV: HR 1.49, CI 1.18–1.88, 0.001) higher risk, after adjusting age, sex, education, cognitive performance, sleep duration/disturbances, comorbidities. In those free dementia, each hour delayed was associated with (HR 1.13, 1.04–1.23, 0.003). amplitude increased new onset 1.31, 1.03–1.67, 0.03 1‐standard deviation decrease). Interpretation Twenty‐four‐hour RAR suppression, fragmentation, potentially risk. Subsequent in cases suppressed rhythms. The presence before prior suggests that may predict involved early disease pathogenesis. ANN NEUROL 2023;93:1145–1157

Language: Английский

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Molecular Connections Between Circadian Clocks and Aging

Journal of Molecular Biology, Journal Year: 2019, Volume and Issue: 432(12), P. 3661 - 3679

Published: Dec. 27, 2019

Language: Английский

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Influence of circadian rhythms on sports performance

Chronobiology International, Journal Year: 2021, Volume and Issue: 38(11), P. 1522 - 1536

Published: June 1, 2021

Chronobiology is the scientific discipline of study biological rhythms, a term that has gained ground in sports world. Recently numerous studies have indicated time day which are practiced influences achievement good physical performance. The aim this review was to relationship between circadian rhythms and performance, according latest published data. In addition, physiological processes involved response differences type sport athletes' characteristics were studied. A bibliographic search carried out through five databases (Pubmed, Scopus, Researcher Gate, Google Scholar, UOC Library), focusing on articles last ten years written English Spanish. 36 papers met inclusion criteria. Body temperature factor shows pattern with marked peak later afternoon, at performance its highest, i.e. speed, agility, distance covered, jumping power. perception effort also higher afternoon. Regarding chronotype, evening types seem be most affected do their optimal time-of-day. tendency more morning as age increases. Training sessions should planned for each athlete. It's essential take into account individual chronotype. desynchronization can cause decrease

Language: Английский

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The Impact of Physical Activity on the Circadian System: Benefits for Health, Performance and Wellbeing

Applied Sciences, Journal Year: 2022, Volume and Issue: 12(18), P. 9220 - 9220

Published: Sept. 14, 2022

Circadian rhythms are an inherent property of all living systems and essential part the external internal temporal order. They enable organisms to be synchronized with their periodic environment guarantee optimal functioning organisms. Any disturbances, so-called circadian disruptions, may have adverse consequences for health, physical mental performance, wellbeing. The environmental light–dark cycle is main zeitgeber rhythms. Moreover, regular activity most useful. Not only does it general favorable effects on cardiovascular system, energy metabolism example, but also stabilize system via feedback suprachiasmatic nuclei (SCN), pacemaker. Regular helps maintain high-amplitude rhythms, particularly clock gene expression in SCN. It promotes entrainment periodicities improves synchronization various This turn health In experiments Djungarian hamsters, voluntary access a running wheel not stabilized rhythm, intensive even reestablished rhythm arrhythmic individuals. cognitive abilities were restored. hamsters phenotype which SCN do generate signal diminished social memory compromised. Voluntary restored these simultaneously reestablishment rhythm. Intensively exercising Syrian less anxious, more resilient defeat, show defensive/submissive behaviors, i.e., exercise promote self-confidence. Similar described humans. aim present paper summarize current knowledge concerning stability corresponding performance.

Language: Английский

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Digital Biomarkers for Personalized Nutrition: Predicting Meal Moments and Interstitial Glucose with Non-Invasive, Wearable Technologies

Nutrients, Journal Year: 2022, Volume and Issue: 14(21), P. 4465 - 4465

Published: Oct. 24, 2022

Digital health technologies may support the management and prevention of disease through personalized lifestyle interventions. Wearables smartphones are increasingly used to continuously monitor in everyday life, targeting maintenance. Here, we aim demonstrate potential wearables (1) detect eating moments (2) predict explain individual glucose levels healthy individuals, ultimately supporting self-management. Twenty-four individuals collected continuous data from interstitial monitoring, food logging, activity, sleep tracking over 14 days. We demonstrated use monitoring activity detecting with a prediction model showing an accuracy 92.3% (87.2-96%) 76.8% (74.3-81.2%) training test datasets, respectively. Additionally, showed peaks tracking, overall mean absolute error 0.32 (+/-0.04) mmol/L for 0.62 (+/-0.15) data. With Shapley additive explanations, personal elements important predicting were identified, providing basis advice. Pending further validation these digital biomarkers, they show promise type 2 diabetes recommendations.

Language: Английский

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The optimal exercise intervention for sleep quality in adults: A systematic review and network meta-analysis

Preventive Medicine, Journal Year: 2024, Volume and Issue: 183, P. 107955 - 107955

Published: April 18, 2024

Language: Английский

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Physical behaviors and chronotype in people with type 2 diabetes

BMJ Open Diabetes Research & Care, Journal Year: 2020, Volume and Issue: 8(1), P. e001375 - e001375

Published: July 1, 2020

Introduction Previous investigations have suggested that evening chronotypes may be more susceptible to obesity-related metabolic alterations. However, whether device-measured physical behaviors differ by chronotype in those with type 2 diabetes (T2DM) remains unknown. Research design and methods This analysis reports data from the ongoing Chronotype of Patients Type Diabetes Effect on Glycaemic Control (CODEC) observational study. Eligible participants were recruited both primary secondary care settings Midlands area, UK. Participants asked wear an accelerometer (GENEActiv, ActivInsights, Kimbolton, UK) their non-dominant wrist for 7 days quantify different (sleep, sedentary, light, moderate-to-vigorous activity (MVPA), intensity gradient, average acceleration above which most active continuous 2, 10, 30 60 min are accumulated). preference (morning, intermediate or evening) was assessed using Morningness-Eveningness Questionnaire. Multiple linear regression analyses associated timing. Evening considered as reference group. Results 635 included (age=63.8±8.4 years, 34.6% female, body mass index=30.9±5.1 kg/m ). 25% (n=159) cohort morning chronotypes, 52% (n=330) 23% (n=146) chronotypes. had higher sedentary time (28.7 min/day, 95% CI 8.6 48.3) lower MVPA levels (–9.7 –14.9 –4.6) compared The 2-60 day, gradient timing also differed across displaying a later sleep onset consistently time. Conclusions People T2DM lead lifestyle characterized insufficient MVPA. exacerbated ‘eveningness’ (ie, go bed late get up late).

Language: Английский

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Reviewing the Role of Outdoor Lighting in Achieving Sustainable Development Goals

Sustainability, Journal Year: 2021, Volume and Issue: 13(22), P. 12657 - 12657

Published: Nov. 16, 2021

The Sustainable Development Goals (SDGs) aim at providing a healthier planet for present and future generations. At the most recent SDG summit held in 2019, Member States recognized that achievements accomplished to date have been insufficient achieve this mission. This paper presents comprehensive literature review of 227 documents contextualizing outdoor lighting with SDGs, showing its potential resolve some existing issues related targets. From list 17 goals, six SDGs were identified relevant synergies smart cities, including 3 (Good health well-being), 11 (Sustainable cities communities), 14 (Life below water) 15 on land). also links efficient roles partially 7 (Affordable clean energy) 13 (Climate action) through Target 7.3 13.2, respectively. identifies as vector directly impacting 16 50 targets involved. Each section discusses main aspects by human-centric, energy efficiency environmental impacts. aspect addresses studies contributing solutions literature, helping us understand positive negative impacts artificial living beings. In addition, work summarizes proposed results tackling specific topics demands.

Language: Английский

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Circadian Clocks, Redox Homeostasis, and Exercise: Time to Connect the Dots?

Antioxidants, Journal Year: 2022, Volume and Issue: 11(2), P. 256 - 256

Published: Jan. 28, 2022

Compelling research has documented how the circadian system is essential for maintenance of several key biological processes including homeostasis, cardiovascular control, and glucose metabolism. Circadian clock disruptions, or losses rhythmicity, have been implicated in development diseases, premature ageing, are regarded as health risks. Redox reactions involving reactive oxygen nitrogen species (RONS) regulate physiological functions such cell signalling immune response. However, oxidative stress associated with pathological effects RONS, resulting a loss damaging modifications to important molecules DNA. Direct connections established between rhythms on basis that disruptions can affect redox biology, vice versa, bi-directional relationship. For instance, expression activity antioxidant enzymes (SOD, GPx, CAT) appear follow patterns. Consequently, ability unravel these interactions opened an exciting area biology. Exercise exerts numerous benefits and, potent environmental cue, capacity adjust disrupted systems. In fact, response given exercise stimulus may also exhibit variation. At same time, relationship exercise, scrutinised, whereby it clear exercise-induced RONS elicit both helpful potentially harmful dependent type, intensity, duration exercise. To date, appears emerging interface rhythmicity stress/redox metabolism not explored relation This review aims summarise evidence supporting conceptual link clock, stimuli. We believe carefully designed investigations this nexus required, which could be harnessed tackle theories concerned with, example, existence optimal time accrue benefits.

Language: Английский

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