Cited by Advances in Catalytic Asymmetric Hydrogen-Phosphine/Phosphorus Functionalization of Unsaturated Carbon-Carbon Bonds

Amino Turbo Chirality and Its Asymmetric Control DOI

Ting Xu, Yu Wang,

Shengzhou Jin

et al.

Research, Journal Year: 2024, Volume and Issue: 7

Published: Jan. 1, 2024

A series of new targets containing 3 chiral elements central, orientational, and turbo chirality have been designed synthesized asymmetrically. The absolute configurations conformations these types were concurrently controlled by using sulfonimine auxiliary unambiguously determined x-ray diffraction analysis. These include alpha unnatural amino acid derivatives, which may play an important role for drug design, discovery, development. Three propellers framework are covalently connected to a C(sp

Language: Английский

Citations

Copper‐Catalyzed Enantioselective Hydrophosphorylation of Unactivated Alkynes DOI

Jie Kang,

Kang Ding,

Si‐Mu Ren

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 5, 2024

P-stereogenic phosphorus compounds are essential across various fields, yet their synthesis via enantioselective P-C bond formation remains both challenging and underdeveloped. We report the first copper-catalyzed hydrophosphorylation of alkynes, facilitated by a newly designed chiral 1,2-diamine ligand. Unlike previous methods that rely on kinetic resolution with less than 50 % conversion, our approach employs distinct dynamic asymmetric transformation mechanism, achieving complete conversion racemic starting materials. This reaction is compatible broad range aromatic aliphatic terminal producing products high yields (up to 95 %), exclusive cis selectivity, exceptional regio- enantioselectivity (>20 : 1 r.r. up 96 ee). The resulting were further transformed into diverse array enantioenriched scaffolds. Preliminary mechanistic studies conducted elucidate details.

Language: Английский

Citations

Enantioselective Desymmetrization of Phosphinic Acids via Cu-Catalyzed O-Arylation DOI

Ming Yan, Jiawei Zou, Dongmei Fang

et al.

ACS Catalysis, Journal Year: 2025, Volume and Issue: unknown, P. 4719 - 4725

Published: March 6, 2025

Language: Английский

Citations

Synthesis of P‐Stereogenic Compounds by Transition Metal‐Catalyzed Asymmetric Transformation of H−P(O) Compounds: Progress, Challenges, and Prospects DOI

Kang Ding,

Bo Su

European Journal of Organic Chemistry, Journal Year: 2023, Volume and Issue: 27(4)

Published: Dec. 5, 2023

Abstract The synthesis of P‐stereogenic phosphorus compounds has gained considerable attention due to their wide applications across many research fields. Among the available strategies, transition metal‐catalyzed asymmetric transformation pentavalent phosphoryl (H−P(O)) precursors is particularly appealing. This approach involves a direct C−P bond‐forming process, rendering it straightforward, and employs readily available, bench‐stable H−P(O) reagents that are compatible with various metal catalysts. Recent years have witnessed significant progress in this field, primary focus on cross‐couplings hydrophosphorylations. Concept article provides brief summary recent progress, highlights existing challenges, discusses future directions exciting area.

Language: Английский

Citations

Asymmetric Hydrophosphination of Diarylphosphine Oxides to α,β-Unsaturated Bifunctional Compounds Catalyzed by Chiral Oxazaborolidine DOI

Qi Gao,

Lirong Chen,

Jinyi Qian

et al.

Acta Chimica Sinica, Journal Year: 2024, Volume and Issue: 82(7), P. 742 - 742

Published: Jan. 1, 2024

Language: Английский

Citations

Copper‐Catalyzed Enantioselective Hydrophosphorylation of Unactivated Alkynes DOI

Jie Kang,

Kang Ding,

Si‐Mu Ren

et al.

Angewandte Chemie, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 5, 2024

Abstract P‐stereogenic phosphorus compounds are essential across various fields, yet their synthesis via enantioselective P−C bond formation remains both challenging and underdeveloped. We report the first copper‐catalyzed hydrophosphorylation of alkynes, facilitated by a newly designed chiral 1,2‐diamine ligand. Unlike previous methods that rely on kinetic resolution with less than 50 % conversion, our approach employs distinct dynamic asymmetric transformation mechanism, achieving complete conversion racemic starting materials. This reaction is compatible broad range aromatic aliphatic terminal producing products high yields (up to 95 %), exclusive cis selectivity, exceptional regio‐ enantioselectivity (>20 : 1 r.r. up 96 ee). The resulting were further transformed into diverse array enantioenriched scaffolds. Preliminary mechanistic studies conducted elucidate details.

Language: Английский

Citations

Advances in Catalytic Asymmetric Hydrogen-Phosphine/Phosphorus Functionalization of Unsaturated Carbon-Carbon Bonds DOI

Ting-Jia Sun,

Guoyin Sun,

Wei Sun

et al.

Chinese Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 44(12), P. 3647 - 3647

Published: Jan. 1, 2024

Language: Английский

Citations