Clinical characteristics of the severe acute respiratory syndrome coronavirus 2 omicron variant compared with the delta variant: a retrospective case-control study of 318 outpatients from a single sight institute in Japan DOI Creative Commons
Keiko Suzuki, Takaya Ichikawa, Satoshi Suzuki

et al.

PeerJ, Journal Year: 2022, Volume and Issue: 10, P. e13762 - e13762

Published: Aug. 2, 2022

Background Clinical characteristics, including laboratory parameters, of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant have been limited. Methods This retrospective case-control study was conducted in a single hospital. Patients with disease 2019 (COVID-19) who visited Asahikawa City Hospital outpatient department as new patients and underwent blood tests were included this study. We analyzed data from January 2022 to April during phase 2021 October Delta phase. treated at other hospitals after visiting our hospital excluded. All performed before treatment for COVID-19 initiated. Demographic information, data, clinical courses extracted electronic medical records. matched two groups by age comorbidities compared their characteristics. also factors associated pneumonia Results A total 151 167 delta The mean age, rate comorbidities, vaccination significantly higher group. number or those requiring oxygen, admissions, both lower Lactate dehydrogenase (LDH), C-reactive protein (CRP), ferritin, aspartate aminotransferase (AST), neutrophil-to-lymphocyte ratio (NLR) levels Compared mild symptom group, older body mass index (BMI), non-vaccination, LDH, CRP Conclusion is reduction hospitalization risk real-life setting. In variant, related high-risk factors, such LDH levels, no vaccination.

Language: Английский

Impact of long-COVID on health-related quality of life in Japanese COVID-19 patients DOI Creative Commons
Shinya Tsuzuki, Yusuke Miyazato, Mari Terada

et al.

Health and Quality of Life Outcomes, Journal Year: 2022, Volume and Issue: 20(1)

Published: Aug. 19, 2022

The empirical basis for a quantitative assessment of the disease burden imposed by long-COVID is currently scant. We aimed to inform caused in Japan.We conducted cross sectional self-report questionnaire survey. was mailed 526 eligible patients, who were recovered from acute COVID-19 April 2021. Answers classified into two groups; participants have no symptom and those any ongoing prolonged symptoms that lasted longer than four weeks at time estimated average treatment effect (ATE) on EQ-VAS EQ-5D-3L using inverse probability weighting. In addition prolongation, we investigated whether other factors (including demography, lifestyle, severity) associated with low values, multivariable linear regression.349 reported 108 showed lower value (69.9 vs 82.8, respectively) (0.85 0.96, reporting considering ATE symptoms. - 12.9 [95% CI 15.9 9.8], it 0.11 0.13 0.09], implying negative impact patients' score. regression, only having scores (- 11.7 15.0 8.5] 0.10 0.08] EQ-5D-3L).Due their long duration, represent substantial expressed health-related quality life.

Language: Английский

Citations

47
Clinical characteristics of COVID-19 in hospitalized children during the Omicron variant predominant period DOI
Kensuke Shoji, Takayuki Akiyama, Shinya Tsuzuki

et al.

Journal of Infection and Chemotherapy, Journal Year: 2022, Volume and Issue: 28(11), P. 1531 - 1535

Published: Aug. 10, 2022

Language: Английский

Citations

45
Duration of protection of CoronaVac plus heterologous BNT162b2 booster in the Omicron period in Brazil DOI Creative Commons
Thiago Cerqueira‐Silva, Vinícius de Araújo Oliveira, Enny S. Paixão

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: July 18, 2022

To date, no information has been published on the effectiveness of inactivated whole-virus COVID-19 vaccines plus heterologous booster against symptomatic infection and severe outcomes (hospitalization or death) during dominance SARS-CoV-2 Omicron variant period. We evaluated vaccine (VE) CoronaVac BNT162b2 period in Brazil (January to April 2022). Using a test-negative design, we analysed data for 2,471,576 individuals tested variant's dominant using nationally linked database from Brazil. Compared unvaccinated, vaccinees maintained protection outcomes, with an estimated VE 84.1% (95% CI:83.2-84.9) at more than 120 days after booster. Furthermore, while detected high level up 79 years old, waning was observed aged ≥80 years, decreasing 81.3% CI:77.9-84.2) 31-60 72.9% CI:70.6-75.1) dose. However, significant this time In conclusion, except dose offered durable due Omicron.

Language: Английский

Citations

42
Prognosis of Myocarditis Developing After mRNA COVID-19 Vaccination Compared With Viral Myocarditis DOI Creative Commons
Francisco Tsz Tsun Lai, Edward W. Chan, Lei Huang

et al.

Journal of the American College of Cardiology, Journal Year: 2022, Volume and Issue: 80(24), P. 2255 - 2265

Published: Dec. 1, 2022

Language: Английский

Citations

41
Association of SARS-CoV-2 BA.4/BA.5 Omicron lineages with immune escape and clinical outcome DOI Creative Commons
Joseph A. Lewnard, Vennis Hong,

Jeniffer S. Kim

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: March 14, 2023

Abstract Expansion of the SARS-CoV-2 BA.4 and BA.5 Omicron subvariants in populations with prevalent immunity from prior infection vaccination, associated burden severe COVID-19, has raised concerns about epidemiologic characteristics these lineages including their association immune escape or clinical outcomes. Here we show that BA.4/BA.5 cases a large US healthcare system had at least 55% (95% confidence interval: 43–69%) higher adjusted odds documented than time-matched BA.2 cases, as well 15% (9–21%) 38% (27–49%) having received 3 ≥4 COVID-19 vaccine doses, respectively. However, after adjusting for differences among each lineage, was not differential risk emergency department presentation, hospital admission, intensive care unit admission following an initial outpatient diagnosis. This finding held sensitivity analyses correcting potential exposure misclassification resulting unascertained infections. Our results demonstrate reduced severity (BA.1 BA.2) lineages, relative to Delta variant, persisted BA.4/BA.5, despite increased breakthrough previously vaccinated infected individuals.

Language: Английский

Citations

31
Comparative analysis of mortality in patients admitted with an infection with influenza A/B virus, respiratory syncytial virus, rhinovirus, metapneumovirus or SARS‐CoV‐2 DOI Creative Commons
Hanneke Boon, Arend‐Jan Meinders,

Erik J. van Hannen

et al.

Influenza and Other Respiratory Viruses, Journal Year: 2024, Volume and Issue: 18(1)

Published: Jan. 1, 2024

Abstract Background While influenza virus and severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) are recognised as a cause of illness mortality, clinical interest for syncytial (RSV), rhinovirus human metapneumovirus (hMPV) infections is still limited. Methods We conducted retrospective database study comparing baseline characteristics 30‐day mortality in large cohort adult patients admitted an overnight stay or longer with (A/B), rhinovirus, hMPV, RSV SARS‐CoV‐2 infection. For non‐SARS‐CoV‐2 viruses, data were included the period July 2017–February 2020. SARS‐CoV‐2, between March 2020 2022 included. Results Covariate‐adjusted following RSV, hMPV was substantial (crude 8–10%) comparable hospitalisation A Mortality infection consistently higher than any other virus, at point time 14–25%). Odds compared declined from 4.9 to 1.7 over course pandemic. Patients had less comorbidity more often male. In this cohort, age related hospitalisation, while association not apparent. Conclusions With exception infections, we find outcome common requiring similar assumed. The observed significantly higher, but difference viruses became distinct time.

Language: Английский

Citations

15
The changing demographics and severity in hospitalized patients Across COVID-19 Variants: A National Cohort Study DOI Creative Commons
Priyanka Parajuli,

Lisa Phipps,

Roy Sabo

et al.

Journal of Clinical and Translational Science, Journal Year: 2025, Volume and Issue: 9(1)

Published: Jan. 1, 2025

The respiratory syndrome coronavirus (SARS-CoV-2) has undergone genetic evolution and led to variants of concern that vary in transmissibility clinical severity. This retrospective cohort analysis studied 232,364 hospitalized COVID-19-positive patients the National COVID Cohort Collaborative [April 27, 2020 June 25, 2022]. primary outcomes were compare demographics need for mechanical ventilation 30-day mortality across including Alpha (B.1.1.7), Delta (B.1.617.2), Omicron (B.1.1.529). severity SARS-CoV-2 decreased omicron-subsequent wave with utilization among comorbidities like diabetes mellitus, obesity, liver disease. Although each subsequent wave, sex distribution remained equal constant, there was an increase rates diabetes, disease, disease amongst COVID-19 over waves despite decreasing ventilation. Despite changes time, more recent associated mortality. These observations will help guide specific effective resource allocation patient care.

Language: Английский

Citations

1
Endothelial Dysfunction in COVID-19: Potential Mechanisms and Possible Therapeutic Options DOI Creative Commons
Maria Chiara Pelle, Isabella Zaffina, Stefania De Luca

et al.

Life, Journal Year: 2022, Volume and Issue: 12(10), P. 1605 - 1605

Published: Oct. 14, 2022

SARS-CoV-2, a novel coronavirus found in Wuhan (China) at the end of 2019, is etiological agent current pandemic that heterogeneous disease, named disease 2019 (COVID-19). SARS-CoV-2 affects primarily lungs, but it can induce multi-organ involvement such as acute myocardial injury, myocarditis, thromboembolic eventsandrenal failure. Hypertension, chronic kidney diabetes mellitus and obesity increase risk severe complications COVID-19. There no certain explanation for this systemic COVID-19 involvement, could be related to endothelial dysfunction, due direct (endothelial cells are infected by virus) indirect damage (systemic inflammation) factors. Angiotensin-converting enzyme 2 (ACE2), expressed human endothelium, has fundamental role respiratory syndrome (SARS-CoV-2) infection. In fact, ACE2 used receptor leading downregulation these receptors on cells; once inside, virus reduces integrity tissue, with exposure prothrombotic molecules, platelet adhesion, activation coagulation cascades and, consequently, vascular damage. Systemic microangiopathy thromboembolism lead failure an elevated death. Considering crucial immunological response developing form COVID-19, review, we will attempt clarify underlying pathophysiological mechanisms.

Language: Английский

Citations

36
COVID-19 Variants in Critically Ill Patients: A Comparison of the Delta and Omicron Variant Profiles DOI Creative Commons
Alberto Corriero,

Mario Ribezzi,

Federica Mele

et al.

Infectious Disease Reports, Journal Year: 2022, Volume and Issue: 14(3), P. 492 - 500

Published: June 17, 2022

Background: Coronavirus disease is a pandemic that has disrupted many human lives, threatening people’s physical and mental health. Each wave struck in different ways, infectiveness-wise mortality-wise. This investigation focuses on critically ill patients affected by the last two variants, Delta Omicron, aims to analyse if any difference exists between groups. Methods: intensive care unit (ICU) COVID-19 consecutive admissions 1 October 2021 31 March 2022 were recorded daily, data concerning patients’ demographics, main comorbidities, ICU parameters admission, outcome analysed univariate procedure multivariate analysis. Results: 65 enrolled, (47.69%) belonging Omicron versus 34 (52.31%) group. The mortality rate was 52.94% for group 41.9% A analysis showed variant associated with total comorbidities number, Charlson Comorbidity Index (CCI), pre-existing pulmonary disease, vaccination status, acute kidney injury (AKI). In stepwise analysis, number of positively group, while embolism negatively correlated Conclusion: appears have lost some hallmarks variant, such as endothelialitis more limited cellular tropism when it comes ICU. Further studies are encouraged explore therapeutic approaches treat critical COVID-19.

Language: Английский

Citations

31
Characteristics and outcomes of COVID-19 patients during B.1.1.529 (Omicron) dominance compared to B.1.617.2 (Delta) in 89 German hospitals DOI Creative Commons
Johannes Leiner, Vincent Pellissier, Sven Hohenstein

et al.

BMC Infectious Diseases, Journal Year: 2022, Volume and Issue: 22(1)

Published: Oct. 27, 2022

Abstract Background The SARS-CoV-2 variant B.1.1.529 (Omicron) was first described in November 2021 and became the dominant worldwide. Existing data suggests a reduced disease severity with Omicron infections comparison to B.1.617.2 (Delta). Differences characteristics in-hospital outcomes of COVID-19 patients Germany during period compared Delta are not thoroughly studied. ICD-10-code-based severe acute respiratory (SARI) surveillance represents an integral part infectious control Germany. Methods Administrative from 89 German Helios hospitals retrospectively analysed. Laboratory-confirmed were identified by ICD-10-code U07.1 SARI cases ICD-10-codes J09-J22. stratified concomitant SARI. A nine-week observational between December 6, February 2022 defined divided into three phases respect dominating virus (Delta, transition, Omicron). Regression analyses adjusted for age, gender Elixhauser comorbidities applied assess patient outcomes. Results total cohort 4,494 inpatients Patients dominance younger (mean age 47.8 vs. 61.6; p < 0.01), more likely be female (54.7% 47.5%; 0.01) characterized lower comorbidity burden index 5.4 8.2; 0.01). Comparing periods, at significantly risk intensive care treatment (adjusted odds ratio 0.72 [0.57–0.91]; = 0.005), mechanical ventilation 0.42 [0.31–0.57]; 0.001), mortality [0.32–0.56]; 0.001). This also mostly separate COVID-SARI group. During case numbers without exceeded time pandemic’s course. Conclusion Patient differ as suggesting infections. might play crucial role assessing future variants.

Language: Английский

Citations

29