Current Neurology and Neuroscience Reports, Journal Year: 2025, Volume and Issue: 25(1)
Published: Feb. 8, 2025
Language: Английский
Journal of Alzheimer s Disease, Journal Year: 2024, Volume and Issue: 99(4), P. 1333 - 1348
Published: May 17, 2024
Background: There is increasing evidence from animal and clinical studies that network hyperexcitability (NH) may be an important pathophysiological process potential target for treatment in early Alzheimer’s disease (AD). Measures of functional connectivity (FC) have been proposed as promising biomarkers NH, but it unknown which measure has the highest sensitivity early-stage changes excitation/inhibition balance. Objective: We aim to test performance different FC measures detecting NH at earliest stage using a computational approach. Methods: use whole brain model activity dependent degeneration simulate progressive AD pathology NH. investigate if what four (amplitude envelope correlation corrected [AECc], phase lag index [PLI], joint permutation entropy [JPE] new measure: time [PLT]) can detect pathophysiology. Results: The replicates spectral line with data demonstrates Compared relative theta power gold standard AECc PLI are shown less sensitive AD-related neurophysiological abnormalities, while JPE PLT show more excellent characteristics. Conclusions: Novel measures, better rapid fluctuations neural connectivity, superior well-known such abnormalities particular AD. These markers could improve diagnosis identification.
Language: Английский
Citations
4
Alzheimer s & Dementia, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 29, 2024
Many coronavirus disease 2019 (COVID-19) positive individuals exhibit abnormal electroencephalographic (EEG) activity reflecting "brain fog" and mild cognitive impairments even months after the acute phase of infection. Resting-state EEG abnormalities include slowing (reduced alpha rhythm; increased slow waves) epileptiform activity. An expert panel conducted a systematic review to present compelling evidence that deficits due COVID-19 Alzheimer's related dementia (ADRD) are driven by overlapping pathologies neurophysiological abnormalities. seen in patients resemble those observed early stages neurodegenerative diseases, particularly ADRD. It is proposed similar Long COVID ADRD parallel neuroinflammation, astrocyte reactivity, hypoxia, neurovascular injury. These underpinning decline can be detected routine exams. Future research will explore value monitoring for predicting long-term outcomes efficacy therapeutic interventions. HIGHLIGHTS: Abnormal intrinsic electrophysiological brain activity, such as EEG, reduced wave, characteristic findings patients. have potential neural biomarkers identify neurological complications at stage disease, assist clinical assessment, assess risk Similar typically with impairments, Evidence presented supports idea resulting, least part, from neuroinflammatory mechanisms reactivity. Identifying common biological highlight critical underlying disorders decline. elucidates questions regarding impairment not yet been adequately investigated.
Language: Английский
Citations
4
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(1), P. 356 - 356
Published: Jan. 3, 2025
Patients with mild cognitive impairment due to Alzheimer’s disease (ADMCI) typically show abnormally high delta (<4 Hz) and low alpha (8–12 rhythms measured from resting-state eyes-closed electroencephalographic (rsEEG) activity. Here, we hypothesized that the abnormalities in rsEEG activity may be greater ADMCI patients than those MCI not AD (noADMCI). Furthermore, they associated diagnostic cerebrospinal fluid (CSF) amyloid–tau biomarkers patients. An international database provided clinical–demographic–rsEEG datasets for cognitively unimpaired older (Healthy; N = 45), (N 70), noADMCI 45) participants. The spanned individual delta, theta, frequency bands. eLORETA freeware estimated cortical sources. Posterior source activities were reduced group compared only Healthy but also (p < 0.001). Negative associations between CSF phospho-tau total tau levels posterior observed 0.001), whereas amyloid beta 42 marginal. These results suggest neurophysiological brain neural oscillatory synchronization mechanisms regulating arousal vigilance through are mainly affected by tauopathy
Language: Английский
Citations
0
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 13, 2025
Abstract Excitation‐inhibition (E/I) imbalance is theorized as a key mechanism in the pathophysiology of epilepsy, with ample research focusing on elucidating its cellular manifestations. However, few studies investigate E/I at macroscale, whole‐brain level, and microcircuit‐level mechanisms clinical significance remain incompletely understood. Here, Hurst exponent, an index ratio, computed from resting‐state fMRI time series, microcircuit parameters are simulated using biophysical models. A broad decrease exponent observed pharmaco‐resistant temporal lobe epilepsy (TLE), suggesting more excitable network dynamics. Connectome decoders point to temporolimbic frontocentral cortices plausible epicenters imbalance. Furthermore, computational simulations reveal that enhancing cortical excitability TLE reflects atypical increases recurrent connection strength local neuronal ensembles. Mixed cross‐sectional longitudinal analyses show stronger ratio elevation patients longer disease duration, frequent electroclinical seizures well interictal epileptic spikes, worse cognitive functioning. exponent‐informed classifiers discriminate healthy controls high accuracy (72.4% [57.5%–82.5%]). Replicated independent dataset, this work provides vivo evidence macroscale shift balance points progressive functional imbalances relate decline.
Language: Английский
Citations
0
Current Neurology and Neuroscience Reports, Journal Year: 2025, Volume and Issue: 25(1)
Published: Feb. 8, 2025
Language: Английский
Citations
0