Dynamic changes in somatosensory and cerebellar activity mediate temporal recalibration of self-touch

Communications Biology, Journal Year: 2024, Volume and Issue: 7(1)

Published: May 3, 2024

Abstract An organism’s ability to accurately anticipate the sensations caused by its own actions is crucial for a wide range of behavioral, perceptual, and cognitive functions. Notably, sensorimotor expectations produced when touching one’s body attenuate such sensations, making them feel weaker less ticklish rendering easily distinguishable from potentially harmful touches external origin. How brain learns keeps these action-related sensory updated unclear. Here we employ psychophysics functional magnetic resonance imaging pinpoint behavioral neural substrates dynamic recalibration expected temporal delays in self-touch. Our psychophysical results reveal that self-touches are attenuated after systematic exposure delayed self-generated touches, while responses contralateral somatosensory cortex normally distinguish between nondelayed become indistinguishable. During exposure, ipsilateral anterior cerebellum shows increased activity, supporting proposed role recalibrating predictions. Moreover, cingulate areas gradually increase, suggesting as delay adaptation progresses, trigger activity related conflict. Together, our show predictions simplest act upheld sophisticated flexible mechanism maintains accurate time.

Language: Английский

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Schizophrenia and the bodily self

Schizophrenia Research, Journal Year: 2024, Volume and Issue: 269, P. 152 - 162

Published: May 29, 2024

Despite the historically consolidated psychopathological perspective, on one hand, contemporary organicistic psychiatry often highlights abnormalities in neurotransmitter systems like dysregulation of dopamine transmission, neural circuitry, and genetic factors as key contributors to schizophrenia. Neuroscience, other, has so far almost entirely neglected first-person experiential dimension this syndrome, mainly focusing high-order cognitive functions, such executive function, working memory, theory mind, like. An alternative view posits that schizophrenia is a self-disorder characterized by anomalous self-experience awareness. This may not only shed new light features psychosis but also inspire empirical research targeting bodily neurobiological changes underpinning disorder. Cognitive neuroscience can today address classic topics phenomenological psychopathology adding level description, finally enabling correlation between aspects psychiatric diseases their roots. Recent evidence basis minimal notion self, presented. The relationship body, its motor potentialities self illustrated. Evidence mechanisms plasticity, blurring self-other distinction schizophrenic patients introduced discussed. It concluded brain-body function anomalies multisensory integration, differential processing self- other-related information mediating self-experience, might be at disruption disorders characterizing

Language: Английский

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Brief Temporal Perturbations in Somatosensory Reafference Disrupt Perceptual and Neural Attenuation and Increase Supplementary Motor Area–Cerebellar Connectivity

Journal of Neuroscience, Journal Year: 2023, Volume and Issue: 43(28), P. 5251 - 5263

Published: June 20, 2023

Intrinsic delays in sensory feedback can be detrimental for motor control. As a compensation strategy, the brain predicts consequences of movement via forward model on basis copy command. Using these predictions, attenuates somatosensory reafference to facilitate processing exafferent information. Theoretically, this predictive attenuation is disrupted by (even minimal) temporal errors between predicted and actual reafference; however, direct evidence such disruption lacking as previous neuroimaging studies contrasted nondelayed reafferent input with input. Here, we combined psychophysics functional magnetic resonance imaging test whether subtle perturbations timing disrupt its processing. Twenty-eight participants (14 women) generated touches their left index finger tapping sensor right finger. The were delivered close time contact two fingers or perturbation (i.e., 153 ms delay). We found that brief at both perceptual neural levels, leading greater cerebellar responses weaker connectivity cerebellum, proportional changes. interpret effects failure predictively attenuate perturbed reafference. Moreover, observed increased supplementary area cerebellum during perturbations, which could indicate communication prediction error back centers. SIGNIFICANCE STATEMENT Our receives from our movements delay. To counteract delays, control theories postulate sensations received time. Thus, self-generated touch feels than an identical external touch. However, how perturb remains unknown. show make otherwise attenuated feel stronger, elicit stronger responses, weaken areas, increase areas. These findings areas are fundamental forming predictions about movements.

Language: Английский

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Temporal action-effect prediction does not affect perceived loudness, but the sense of agency

Consciousness and Cognition, Journal Year: 2025, Volume and Issue: 130, P. 103837 - 103837

Published: March 8, 2025

Motor theories propose that predicting sensory consequences of one's own actions reduces perception and neural processing these action-effects, a phenomenon known as attenuation, considered an implicit measure agency. However, recent findings question the link between action-effect prediction attenuation. This study directly examined temporal auditory alongside assessing self-reported Participants experienced self-initiated effects with varying latencies compared their loudness to reference tone, whose intensities were modulated discrimination. Results showed no change in perceived across delays, while agency ratings decreased longer delays. A second experiment controlled for hazard rate effects, confirming initial findings. Our results contrast previous behavioral from tactile modality conclusions drawn electroencephalography. We suggest reconsidering attenuation necessary consequence

Language: Английский

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Divisive attenuation based on noisy sensorimotor predictions accounts for excess variability in self-touch

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 24, 2024

Abstract When one part of the body exerts force on another, resulting tactile sensation is perceived as weaker than when same applied by an external agent. This phenomenon has been studied using a matching task, in which observers are first exposed to passive finger and then instructed reproduce directly pressing with other hand: healthy participants consistently exceed original level. However, this exaggeration target not observed if observer generates indirectly, adjusting joystick or slider that controls output motor. Here we present detailed computational account processes leading forces incorporating attenuation sensory signals based motor predictions. The model elucidates previously unappreciated contributions multiple sources noise, including memory determining output. We show predictive component can be isolated quantifying discrepancy between direct indirect self-generated forces, rather versus externally generated forces. Our makes prediction attenuated sensations will display greater trial-to-trial variability unattenuated ones, because they incorporate additional noise from prediction. Quantitative fitting data close 500 human confirmed excess provided evidence for divisive subtractive mechanism attenuation, while highlighting its nature.

Language: Английский

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Costs and benefits of temporal expectations on somatosensory perception and decision-making

Cognition, Journal Year: 2025, Volume and Issue: 261, P. 106146 - 106146

Published: April 14, 2025

Our perception is shaped by prior expectations, including those about the timing of our sensations. These temporal expectations can be formed recognizing patterns in onset sensory inputs. However, somatosensory domain, it remains unclear how these impact speed and accuracy judgments, as previous research has yielded mixed results. Here, participants used auditory tones to anticipate forces applied their fingers discriminated intensity compared a reference force. Experiment 1 showed that had worse discrimination sensitivity higher thresholds for expected versus unexpected forces. 2 replicated extended costs include perceptual accuracy, even when comparing expectation-free forces, further revealed reaction time benefits. Drift-diffusion modelling suggested speeded non-decisional processes while simultaneously slowing evidence accumulation. findings demonstrate both benefits decision-making.

Language: Английский

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Aging exerts a limited influence on the perception of self-generated and externally generated touch

Journal of Neurophysiology, Journal Year: 2023, Volume and Issue: 130(4), P. 871 - 882

Published: Aug. 23, 2023

Touch generated by our voluntary movements is attenuated both at the perceptual and neural levels compared with touch of same intensity delivered to body another person or machine. This somatosensory attenuation phenomenon relies on integration input predictions about consequences actions. Previous studies have reported increased in elderly people, proposing an overreliance sensorimotor compensate for age-related declines perception; however, recent results challenged this direct relationship. In a preregistered study, we used force-discrimination task assess whether aging increases increase explained decreased precision individuals. Although 94% sample (

Language: Английский

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Excitability modulations of somatosensory perception do not depend on feedforward neuronal population spikes

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 17, 2024

Abstract Neural states shape perception at earliest cortical processing levels. Previous work in humans showed a relationship between initial excitation, as indicated by the N20 component of somatosensory evoked potential (SEP), pre-stimulus alpha oscillations, and perceived intensity discrimination paradigm. Here we address follow-up question whether these excitability dynamics reflect changes feedforward or feedback signals. We leveraged high-frequency oscillations (HFO) metric for neuronal population spiking activity first excitatory volley cortex, non-invasively extracted from electroencephalography (EEG) data 32 male human participants. Using Bayesian statistics, found evidence against involvement HFO moment-to-moment variability stimulus intensity, contrast to previously observed effects. Given that presumably reflects backpropagating membrane potentials towards apical dendrites, argue top-down processes (e.g., related oscillations) may thus rely on modulations distal dendritic sites involved pyramidal cells rather than output firing their basal compartments.

Language: Английский

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Predictions of bimanual self-touch determine the temporal tuning of somatosensory perception

iScience, Journal Year: 2024, Volume and Issue: 28(2), P. 111643 - 111643

Published: Dec. 19, 2024

Language: Английский

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Learning to Attenuate Myself: A Predictive Processing Account of the Body-Scan Meditation

Published: April 9, 2024

The practice of meditation consists in allocating attention on sensory stimuli. As it is commonly known, allocation tends to increase both the cortical and phenomenal response target. Yet, deep contemplative states practitioners often report feel a complete dissolution body boundaries, i.e. state banga (in Pali). This phenomenon creates tension with existing literature attention: How does decrease perception target instead increasing it? paper aims at solving by examining computational, phenomenological, embodied approaches practices. body-scan technique (Vipassana tradition) taken as an exemplary that leads bhanga. Through predictive processing account attentional processes body-scan, I propose “overly attenuated” practitioner may render phenomenology For this purpose, first present its (section 1, 2). Then, relevant concepts Predictive Processing framework 3), analysis 4). claim enhances accuracy (low-level) predictions somatosensory cues, which turn attenuate them. mechanism, suggest, underlie short-term body-scan. Finally, implications linking future outlooks are examined 5).

Language: Английский

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