Effects of vitamin C and D on the mRNA expression of angiotensin converting enzyme 2 receptor, cathepsin L, and transmembrane serine protease in the mouse lungs

Libyan Journal of Medicine, Journal Year: 2022, Volume and Issue: 17(1)

Published: March 21, 2022

Vitamins (Vit) C and D are widely used as immunogenic supplements among severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected patients. The SAR-CoV-2 virus enters into the pulmonary endothelial cells through attachment to angiotensin converting enzyme receptor (Ace2) proteolytic activity of Cathepsin L (Ctsl) transmembrane serine protease (Tmprss2) enzymes. This study aimed determine influence Vit on mRNA expression Ace2, Tmprss2, Ctsl genes in mouse lungs. were administrated different groups mice intra-peritoneal route doses equivalent human for 30 days. Then, SARS-CoV-2 entry gene was analyzed using qRT-PCR. It is found that D, but not C, upregulated significantly (P < 0.05) Ace2 by more than six folds, while downregulated Tmprss2 2.8 2.2 respectively. can be concluded from this alters Tmprss, finding help us understanding, at least part, molecular involved cells.

Language: Английский

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Association between diet quality and BMI with side effects of Pfizer-BioNTech COVID-19 vaccine and SARS-CoV-2 immunoglobulin G titers

Nutrition & Food Science, Journal Year: 2022, Volume and Issue: 53(4), P. 738 - 751

Published: Dec. 29, 2022

Purpose The nutritional and anthropometric status can be essential in determining their immune response to vaccines. purpose of this paper was investigate the association between diet quality indices with side effects Pfizer-BioNTech COVID-19 vaccine SARS-CoV-2 immunoglobulin G titer among Kurdish adults. Design/methodology/approach This cross-sectional survey-based study conducted December 2021 February 2022. included data on 115 adults, 20–89 years old, from Kurdistan region. Dietary information collected using a short food frequency questionnaire, assessed plant-based healthy score. A blood test performed measure immunoglobin (IgG) after vaccination's first second doses. Findings Overweight obese subjects reported more local pain, myalgia, headache, bruising reactions receiving dose ( p = 0.04). People less myalgia headache 0.04) 0.01) vaccine. On other hand, authors observed that those dietary habits had IgG doses vaccination than 0.001). Originality/value results showed participants normal weight fewer people diet.

Language: Английский

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Machine learning-driven development of a disease risk score for COVID-19 hospitalization and mortality: a Swedish and Norwegian register-based study

Frontiers in Public Health, Journal Year: 2023, Volume and Issue: 11

Published: Dec. 7, 2023

Aims To develop a disease risk score for COVID-19-related hospitalization and mortality in Sweden externally validate it Norway. Method We employed linked data from the national health registries of Norway to conduct our study. focused on individuals with confirmed SARS-CoV-2 infection through RT-PCR testing up August 2022 as study cohort. Within this group, we identified hospitalized cases those who were admitted hospital within 14 days positive matched them five controls same cohort not due SARS-CoV-2. Additionally, died 30 after being COVID-19. scores, considered various factors, including demographics, infectious, somatic, mental conditions, recorded diagnoses, pharmacological treatments. also conducted age-specific analyses assessed model performance 5-fold cross-validation. Finally, performed external validation using Norwegian population COVID-19 December 2021. Results During period, total 124,560 hospitalized, 15,877 following hospitalization. Disease scores both demonstrated predictive capabilities ROC-AUC values 0.70 0.72, respectively, across entire period. Notably, these exhibited correlation likelihood or death. In (consisting 53,744 individuals), predicted an AUC 0.47 death 0.74. Conclusion The showed moderately good predict but poorly predicting when validated.

Language: Английский

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Dietary supplements and nutraceuticals in the recovery of COVID-19: A systematic review and meta-analysis

Nutrition Clinique et Métabolisme, Journal Year: 2022, Volume and Issue: 36(3), P. 173 - 181

Published: July 18, 2022

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Vitamin D Deficiency in Both Oral and Systemic Manifestations in SARS-CoV-2 Infection: Updated Review

Medicina, Journal Year: 2022, Volume and Issue: 59(1), P. 68 - 68

Published: Dec. 28, 2022

The specialized literature emphasizes the fact that vitamin D has a potentially beneficial effect in context of current COVID-19 pandemic. purpose this article is to highlight role D, both prophylactic and curative, treatment patients diagnosed with COVID-19. Even though its relevance still unknown causes various controversies, there currently no specific for There are prevention strategies new vaccination schedules, but additional randomized clinical trials needed combat In addition systemic manifestations SARS-CoV-2 infection, oral disease have also been described literature. etiology associated infection deficiency remains controversial. present studies, such as salivary gland infections, aphthae, erythema, gingivitis, ulcers, etc. reported. This topic, prevalence only few which inconsistent number cases reported since beginning symptomatology polymorphic. Whether manifestation directly caused by or secondary an important topic analyze discuss.

Language: Английский

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