Gender and age differences in the global burden of peptic ulcers: an analysis based on GBD data from 1990 to 2021 DOI Creative Commons

Ruirui Tan,

Dan Zhao, Xiaomei Zhang

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: April 28, 2025

Background Peptic ulcer (PU) is one of the most common gastrointestinal diseases worldwide. With advances in medical technology, global disease burden PU has been effectively controlled. However, recent evidence regarding remains limited. Methods Using publicly available data from Global Burden Disease (GBD) study 1990 to 2021, we analyzed characteristics PU, including trends incidence, prevalence, mortality, disability-adjusted life years (DALYs), lived with disability (YLDs), and lost (YLLs). We employed Joinpoint regression, age-period-cohort (APC) analysis, decomposition autoregressive integrated moving average (ARIMA) modeling evaluate changes influencing factors for each indicator. Results The number cases increased 2,570,413 (95% CI: 2,161,831–2,997,880) 2,854,370 2021 2,438,231–3,264,252), representing a cumulative growth 11.05%. age-standardized incidence rate (ASIR) decreased 57.14 48.61–66.73) per 100,000 population 34.10 29.13–38.97) 2021. deaths due 273,872 247,312–299,718) 230,217 193,005–270,858). Significant gender differences were observed, consistently higher males than females. After controlling period cohort effects, onset tended occur at younger ages, declined across age groups highest was concentrated individuals aged 90 older. In terms future trends, projected continue decreasing over next 15 years. prevalence expected improve, while PU-related mortality likely plateau without significant increases or decreases. Conclusion significantly past three decades. elderly remain risk require continued attention prevention management efforts.

Language: Английский

Gender and age differences in the global burden of peptic ulcers: an analysis based on GBD data from 1990 to 2021 DOI Creative Commons

Ruirui Tan,

Dan Zhao, Xiaomei Zhang

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: April 28, 2025

Background Peptic ulcer (PU) is one of the most common gastrointestinal diseases worldwide. With advances in medical technology, global disease burden PU has been effectively controlled. However, recent evidence regarding remains limited. Methods Using publicly available data from Global Burden Disease (GBD) study 1990 to 2021, we analyzed characteristics PU, including trends incidence, prevalence, mortality, disability-adjusted life years (DALYs), lived with disability (YLDs), and lost (YLLs). We employed Joinpoint regression, age-period-cohort (APC) analysis, decomposition autoregressive integrated moving average (ARIMA) modeling evaluate changes influencing factors for each indicator. Results The number cases increased 2,570,413 (95% CI: 2,161,831–2,997,880) 2,854,370 2021 2,438,231–3,264,252), representing a cumulative growth 11.05%. age-standardized incidence rate (ASIR) decreased 57.14 48.61–66.73) per 100,000 population 34.10 29.13–38.97) 2021. deaths due 273,872 247,312–299,718) 230,217 193,005–270,858). Significant gender differences were observed, consistently higher males than females. After controlling period cohort effects, onset tended occur at younger ages, declined across age groups highest was concentrated individuals aged 90 older. In terms future trends, projected continue decreasing over next 15 years. prevalence expected improve, while PU-related mortality likely plateau without significant increases or decreases. Conclusion significantly past three decades. elderly remain risk require continued attention prevention management efforts.

Language: Английский

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